Cancer Detection and Prevention Volume 29 / Issue 3 (May-Jun 2005)

Table of Contents and Editor's Notes

The peer review process occasionally results in approval of controversial publications that do not necessarily reflect the viewpoint of the editors. Readers of the journal are encouraged to critically review and comment on presented data by submitting a "Letter to the Editor" that may be reprinted in a subsequent issue.

Effect of polymorphisms in XPD, ASE-1, RAI and ERCC1 on the risk of basal cell carcinoma among Caucasians after age 50

Ulla Vogel PhD ; Anja Olsen PhD ; Ha°kan Wallin DrPhil ; Kim Overvad PhD ; Anne Tjønneland PhD ; Bjørn A. Nexø PhD

Carriers of XPD Arg156 Argaka polymorphism had a 1.59-fold increased risk of basal cell carcinoma (BCC). Carriers of the allele RA1 A2485 T had a 2.18-fold increased risk of BCC. None of the other single nucleotide polymorphisms were associated with risk of BCC. >>>

X-ray repair cross-complementing group 1 polymorphisms and cancer risks in Asian populations: A minireview

Tianli Qu MD; Kanehisa Morimoto MSc

A relationship between 194Trp/Trp genotype and esophageal squamous cell carcinoma was observed in the Chinese population. There was no significant association between Arg399Gln polymorphism and lung cancer. However, the interaction of 399Gln/Gln genotype and smoking was associated with a significant lung cancer risk. >>>

p53 immunoexpression: An aid to conventional methods in the screening of precursor lesions of squamous esophageal cancer in patients at high-risk?

Renato B. Fagundes MD, PhD ; Carlos R. Melo MD ; Antonio C.K. Pu¨tten MD ; Luis F. Moreira LF, MD ; Se´rgio G.S. de Barros

In esophageal biopsies the normal appearing mucosa of Lugol unstained areas were associated with esophagitis in 21 to 33%, with low-grade dysplasia in 36% and with high-grade dysplasia and carcinoma in 100% of cases. Lugol unstained areas were p53 positive in 14 to 33% of esophagitis, in 36% of low-grade dysplasia and 100% in high-grade dysplasia and cancer. >>>

Association between subject factors and colorectal cancer screening participation in Ontario, Canada

Farah Ramji MHSc ; Michelle Cotterchio PhD ; Michael Manno MSc ; Linda Rabeneck MD, MPH ; Steven Gallinger MD

Colorectal cancer (CRC) screening participation was strongly associated with a family history of CRC (first-degree relative), a high household income, older age, and hormone replacement therapy (among women). >>>

Electrochemical sensor for immunoassay of carcinoembryonic antigen based on thionine monolayer modified gold electrode

Zong Dai PhD ; Jin Chen ; Feng Yan ; Huangxian Ju MD, PhD

A sensor prepared by immobilizing thionine monolayer on gold electrode was used to determine of serum carcinoembryonic antigen (CEA) levels. The detection limit of 0.2ng/ml for CEA appeared more sensitive than the traditional RIA. The method was simplified by avoiding addition of electron transfer mediator to the solution. >>>

Autoimmune response to anti-apoptotic protein survivin and its association with antibodies to p53 and c-myc in cancer detection

Roxanne Megliorino BS ; Fu-Dong Shi MD, PhD ; Xuan-Xian Peng PhD ; Xiao Wang MD ; Edward K. L. Chan PhD ; Eng M. Tan MD ; Jian-Ying Zhang MD, PhD

Recombinant proteins, survivin, p53 and c-myc were used as antigens in ELISA and Western blot for detection of antibodies to the three proteins. Antibodies to survivin were detected by ELISA in 8.4% with a significant difference for controls. Higher frequencies were observed in sera from patients with uterine cancer (14.8%), lymphoma (13.6%), breast cancer (11.4%) and lung cancer (10.6%). Frequencies to p53 and c-myc were 11.5% and 12.3% respectively. >>>

Identification of differentially expressed proteins during human urinary bladder cancer progression

Ashfaque A. Memon MBBS, MSc ; Jong W. Chang MSc ; Bong R. Oh MD ; Yung J. Yoo PhD

Proteome analysis of RT4 (grade-1) and T24 (grade-3) bladder cancer cell lines revealed extensive down-regulation of NADP-dependent isocitrate dehydrogenase cytoplasmic and peroxiredoxin II in T24 poorly differentiated compared to the RT4 well-differentiated bladder cancer cell line. >>>

Elevated levels of soluble interleukin-2 receptor in serum of patients with hematological or non-hematological malignancies

Kazunori Nakase MD, PhD ; Kota Tsuji MD, PhD ; Sigehisa Tamaki MD, PhD ; Motoaki Tanigawa MD, PhD ; Takeshi Ikeda MD, PhD ; Eiki Miyanishi MD, PhD ; Hiroshi Shiku MD, PhD

Soluble IL-2 receptor (sIL-2R) levels were significantly higher in patients with hematologic and nonhematologic neoplasms than in normal controls. The mean values for patients with hematologic malignancies was 3587 ± 1333 U/ml against 949 ± 102 U/ml in patients with solid neoplasms compared to 306 ± 7 U/ml in normal subjects. >>>

Control of melanoma cell invasion by type IV collagen

Sylvie Pasco PhD ; Bertrand Brassart PhD ; Laurent Ramont MD PhD ; Franc¸ois-Xavier Maquart MD PhD ; Jean-Claude Monboisse PhD

It was shown that a sequence from the alpha3 (IV) NC1 domain inhibits in vivo tumor growth of B16F1 melanoma cells injected to C57BL6 syngenic mice and inhibits capillary-like tubular structure formation by human umbilical vein cultured endothelial cells. The alpha3 (IV) NC1 185-203 peptide reduced melanoma proliferation, migration and invasion, in vitro and in vivo through alpha v beta3 integrin binding. >>>

Community perceptions of suspicious pigmented skin lesions: are they accurate when compared to general practitioners?

Peter D. Baade PhD ; Kevin P. Balanda PhD ; Warren R. Stanton PhD ; John B. Lowe PH ; Chris B. Del Mar MD, FRACGP

Opinions of individuals on identification of a series of skin lesions in 8 photographs were compared with diagnoses by general practitioners using the same photographs. The study revealed that individuals were able to correctly recognize those lesions that required further medical evaluation. >>>

Sensitisation of colon cancer cell lines to butyrate-mediated proliferation inhibition by combined application of indomethacin and NDGA

Peter Galfi DVM, PhD ; Zsuzsa Neogrady DVM, PhD ; Albert Amberger PhD ; Raimund Margreiter MD ; Adam Csordas PhD

Butyrate effectively inhibited HT29 colon cancer cell proliferation. Additional application of indomethacine (IM) or nordihydroguaiaretic acid (NDGA) enhanced the proliferation inhibition. The most efficient inhibition of proliferation was obtained by combined application of the cyclooxygenase inhibitor, IM, and the lipooxygenase inhibitor NDGA. >>>

The suppressed proliferation and premature senescence by ganciclovir in p53-mutated human non-small-lung cancer cells acquiring herpes simplex virus-thymidine kinase cDNA

C.-C. Chiu PhD; C.-H. Li MS; T.-S. Fuh BS; W.-L. Chen BS; C.-S. Huang MS; L.-J. Chen BS; W.H. Ung BS; K. Fang PhD

Ganciclovir was a potent inducer of cell cycle arrest at G2/M phase of human non-small-cell lung cancer carrying mutated p53 alleles and transfected with herpes simplex virus-thymidine kinase cDNA. >>>

Doxorubicin induces cardiomyocyte dysfunction via a p38 MAP kinase-dependent oxidative stress mechanism

L.E. Wold PhD ; N.S. Aberle II BS ; Jun Ren PhD

Doxorubucin impaired ventricular contractile function in isolated adult rat ventricular monocytes though a p38 mitogen-activate protein kinase dependent oxidative stress mechanism. >>>


Herbert E. Nieburgs, MD
Worcester, MA