Cancer Detection and Prevention Volume 29 / Issue 2 (Mar-Apr 2005)

Table of Contents and Editor's Notes

The peer review process occasionally results in approval of controversial publications that do not necessarily reflect the viewpoint of the editors. Readers of the journal are encouraged to critically review and comment on presented data by submitting a "Letter to the Editor" that may be reprinted in a subsequent issue.

Exploring beliefs about cancer among American Samoans: focus group findings

F. Allan Hubbell MD, MSPH; Pat H. Luce MS; Juliet M. McMullin PhD

The majority of American Samoans revealed limited understanding of what is cancer because of lack of educational programs devoted to cancer. A variety of beliefs about the causes of cancer included smoking and excessive alcohol use.  The majority of participants also lacked knowledge of cancer prevention because they rarely participated in cancer prevention programs. >>>

Screening mammography in minnesota cancer patients

Surekha Pagidipala MD, MPH; Sally Bushhouse DVM, PhD

The highest utilization of mammography occurred in the age group 50-64 and was associated with a significant increase in early stage cancer diagnosis. >>>

Hormone replacement therapy and invasive and borderline epithelial ovarian cancer risk

Paul K. Mills, PhD ; Deborah G. Riordan, MPH ; Rosemary D. Cress, DrPH ; David F. Goldsmith, PhD ;

Use of hormone replacement therapy was associated with a significant elevation of ovarian cancer risk. The association was stronger in women who did not have a previous history of hysterectomy or tubal ligation and was stronger in women with no family history of ovarian cancer compared to women with such a history. >>>

Capacity building for the clinical investigation of AIDS malignancy in East Africa

Jackson Orem MB, ChB, MMed; Mwanda W. Otieno MB, ChB, MD; Cecily Banura MB, ChB; Edward Katongole-Mbidde MB, ChB; John L. Johnson MD; Leona Ayers MD; Mahmoud Ghannoum PhD; Pingfu Fu PhD; Ellen G. Feigal MD; Jodi Black PhD; Christopher Whalen MD, MS; Michael Lederman MD; Scot C. Remick MD

American and East African physicians have collaborated to develop pathogenesis-based treatment for AIDS-related malignancies in Africa. A platform of clinical research trials with pragmatic design has been developed to further enhance clinical care and sustain training with partners in East Africa and the United States. >>>

Diets, polymorphisms of methylenetetrahydrofolate reductase (MTHFR), and susceptibility of colon cancer and rectal cancer

Qinting Jiang Medicine MS ; Kun Chen MD, PhD ; Xinyuan Ma BS ; Qilong Li BS ; Weiping Yu MS ; Guotong Shu MS ; Kaiyan Yao BS ;

Adequate intake of folate had a protective effect on colon cancer and individuals with the methylene tetrathydrofolate reductase (MTHFR C677T) genotype had decreased risk of colon cancer. Those with the MTHFR 129C variant allele carrier were associated with a lower risk of rectal cancer. >>>

Selective sensitivity to wasabi-derived 6-(methylsulfinyl)-hexyl isothiocyanate of human breast cancer and melanoma cell lines studied in vitro

Takahiro Nomura PhD; Shoko Shinoda PhD; Takao Yamori PhD; Saeko Sawaki BS; Ikuko Nagata BS; Kazuo Ryoyama PhD; Yoko Fuke PhD

An aromatic component of 6-MITC in Japanese spice, wasabi, inhibited the growth of cancer cells in vitro particularly the breast cancer cell lines MCF-7, MDA-MB-231 and the melanoma cell line LOX-VI. 6-MITC had also an effect on cancer cell survival. >>>

Focal prostate basal cell layer disruptions and leukocyte infiltration are correlated events: A potential mechanism for tumor invasion

Yan-Gao Man, MD, PhD ; Ting Shen, MD, PhD ; Yunge Zhao, MD, PhD ; Qing-Xiang Amy Sang, PhD

Leukocyte infiltration occurred at or near basal cell layer disruptions.  Proliferating tumor cells were located at or near the basal cell disruptions.  The majority of basal cells below focal disruptions had a markedly reduced proliferating cell nuclear antigen expression compared to their adjacent counterparts. >>>

PTEN gene therapy induces growth inhibition and increases efficacy of chemotherapy in prostate cancer

Motoyoshi Tanaka MD; Charles J. Rosser MD; H. Barton Grossman MD

Adenoviral transduction of the PTEN gene significantly inhibited growth of human prostate cancer cell lines PC-3, LNCaP and DU-145.  The recombinant PTEN adenovirus vector (Ad-MMAC) infection produced marked growth suppression or LNCaP cells. Combined PTEN gene therapy with doxorubicin increased the effect on PC-3 and DU-145 cells. >>>

Soluble Fas and Fas ligand provide new information on metastasis and response to chemotherapy in SCLC patients

Makoto Shimizu MD; Masashi Kondo MD; Yasushi Ito MD; Hiroaki Kume MD; Ryujiro Suzuki MD; Kenichi Yamaki MD

Serum soluable Fas levels were found to be higher in small cell lung carcinoma (SCLC) patients with distant metastasis or with extensive disease than in patients without distant metastases or with limited disease.  The neuronal specific enolase concentration of SCLC patients with distant metastasis was significantly higher than that of patients without distant metastsis. >>>

Evaluation of infections in non-small cell lung cancer patients treated with radiotherapy

Süreyya Sarihan ; Ilker Ercan ; Asli Saran ; Sibel Kahraman Çetintas ; Halis Akalin ; Kayihan Engin ;

Infection episodes were diagnosed in 46% of patients with non-small cell lung cancer during radiotherapy.  The most commonly found Gram-negative bacteria were H. influenzae followed by Haemophilus species, P. aeruginosa, S. pneumoniae and S. aureus. Neo-adjuvant chemotherapy and presence of neutropenia were predisposing factors. Median survival was 9 months in patients with infection and 13 months for patients without infection. >>>


Herbert E. Nieburgs, MD
Worcester, MA