Cancer Detection and Prevention Volume 28 / Issue 6 (Nov-Dec 2004)

Table of Contents and Editor's Notes

The peer review process occasionally results in approval of controversial publications that do not necessarily reflect the viewpoint of the editors. Readers of the journal are encouraged to critically review and comment on presented data by submitting a "Letter to the Editor" that may be reprinted in a subsequent issue.

Oxidative stress and lipid peroxidation-derived DNA-lesions in inflammation driven carcinogenesis

Helmut Bartsch PhD; Jagadeesan Nair PhD

Chronic inflammation from viral infection or alcohol abuse may lead to increased adducts in the human liver or urine and may serve as markers for progression of inflammatory-cancer prone diseases. >>>

Helicobacter pylori and gastric cancer prevention is possible: Review

Francis Mégraud MD; Philippe Lehours PharmD

H. pylori infection may increase the risk of distal gastric carcinoma although the role of H. pylori eradication on the incidence of cancer is lacking. Contributing risk factors are related to diet and first-degree relatives with distal gastric carcinoma. >>>

Psychological stress and the risk of breast cancer: a case–control study

Joanna Kruk; Hassan Y. Aboul-Enein

Women with major life events (separation, divorce, death of husband or other family members or serious diseases) and other stress of daily activities and depression were 3.15 times more likely to develop breast cancer than those that did not experience such kinds of stress. >>>

2-Chlorodeoxyadenosine alone and in combination with cyclophosphamide and mitoxantrone induce apoptosis in B chronic lymphocytic leukemia cells in vivo

Malgorzata Rogalinska PhD; Jerzy Z. Blonski MD, PhD; Margaret Hanausek PhD; Zbigniew Walaszekc PhD; Tadeusz Robak MD, PhD; Zofia M. Kilianska PhD

Programmed cell death was induced in mononuclear cells isolated from peripheral blood of patients with B cell chronic lymphocytic leukemia treated with 2-chloro-deoxyadenosine (2-CdA) alone and with combination of CdA and cycloposphamide or with mitoxantrone and cyclophosphamide. >>>

Resveratrol-induced cell growth inhibition and apoptosis is associated with modulation of phosphoglycerate mutase-B in human prostate cancer cells: 2D-SDS-PAGE and mass spectrometry evaluation

Narayanan K. Narayanan PhD; Bhagavathi A. Narayanan PhD; Daniel W. Nixon MD

Resveratrol-treated prostate cancer cells LNCaP, PC-3, and DU145 revealed after 48 h a growth inhibition of 67-70% and induced apoptosis at the rate of 55-65%. Resveratrol altered the expression of several genes involved in glycolysis of prostate cancer cells. >>>

Simulation modeling of change to breast cancer detection age eligibility recommendations in Ontario, 2002–2021

Duncan J.W. Hunter PhD, Sean M. Drake BSc, Samuel E.D. Shortt PhD, MD, John L. Dorland MSc, Ninh Tran BSc

The computer simulation model of breast cancer screening in Ontario predicted that changes of age eligibility requirements would result in the detection of an additional 6610 women with breast cancer requiring treatment at an additional cost 795 Canadian dollars per case. >>>

Increasing trends of cervical adenocarcinoma incidence in Central Italy despite extensive screening programme, 1985–2000

Carmen B. Visioli MD, Marco Zappa MD, Stefano Ciatto MD, Anna Iossa MD, Emanuele Crocetti MD

Adenocarcinoma of the uterine cervix increased significantly among younger women (<55y) but not among older women whereas squamous cell carcinoma decreased only among older women. >>>


Herbert E. Nieburgs, MD
Worcester, MA