Cancer Detection and Prevention Volume 28 / Issue 5 (Sep-Oct 2004)

Table of Contents and Editor's Notes

The peer review process occasionally results in approval of controversial publications that do not necessarily reflect the viewpoint of the editors. Readers of the journal are encouraged to critically review and comment on presented data by submitting a "Letter to the Editor" that may be reprinted in a subsequent issue.

Clinicopathological correlates of aspartyl (asparaginyl) b-hydroxylase over-expression in cholangiocarcinoma

Takashi Maeda M.D., Ph.D.; Ken-ichi Taguchi M.D.; Shin-ichi Aishima M.D.; Mitsuo Shimada M.D., Ph.D.; Deborah Hintz M.D.; Nicholas LaRusso M.D.; Gregory Gores M.D.; Masazumi Tsuneyoshi M.D., Ph.D.; Keizo Sugimachi M.D., Ph.D.; Jack R. Wands M.D.; Suzanne M. de la Monte M.D.

Ninety-two percent of resected intrahepatic cholangiocarcinomas had aspartyl (asparaginyl) beta hydroxylase (AAH) immunoreactivity compared to AAH-negative primary sclerosing cholangitis and normal livers. High levels of AAH expression were significantly associated with an infiltrative growth pattern and large tumor burden, poor differentiation and vascular invasion. >>>

Correlation of elevated plasma levels of two structurally related growth factors, heparin affin related peptide and midkine, in advanced solid tumor patients

Patrick Soulié MD ; Mélanie Héroult PhD ; Isabelle Bernard-Pierrot PhD; Danièle Caruelle PhD; Jean Oglobine PhD; Denis Barritault PhD; José Courty PhD

A test procedure developed to quantify heparin affin related peptide (HARP) and midkine (MK) growth factors revealed increased levels of HARP and MK in patients with advanced tumors and in those with loco-regional or metastatic disease. >>>

Immunosuppressive mechanisms in the microenvironment of malignant pleural effusions

Jan J. Sikora, PhD, Grzegorz T. Dworacki, MD, Mariusz T. Karczmarek, MS, Renata E. Jenek, PhD, Jan O. Zeromski, MD, PhD

Malignant pleural effusions had significantly elevated levels of interleukin-10 and transforming growth factor beta compared to benign effusions. Lymphocytes expressed susceptibility to apoptotic death by high Fas and low FasL. Nuclear membrane proteins were significantly more abandoned in malignant than benign effusions. >>>

A recurrent chromosome 4 marker in primary squamous cell lung cancer

Adriana Beatriz Mimbacas, PhD; José Horacio Cardoso, MD

A chromosome alteration pattern that partially resembled chromosome 4 was identified by use of Hoechst 33258 painting technique. Staining of interphase nuclei with a whole chromosome painting system DNA probe-4-spectrum orange 8359SB revealed fluorescent spots as a marker caused exclusively by material derived from chromosome 4. >>>

Behavioural risk factors for cervical cancer from a prospective study in Khon Kaen, Northeast Thailand

Supannee Sriamporn, Donald Maxwell Parkin, Paola Pisani, Krittika Suwanrungruang, Prasit Pengsaa

An increased risk of cervical cancer was associated with early menarche and with more than 3 pregnancies. A family history of cancer, contraceptive use, alcohol consumption, number of sexual partners, and sexually transmitted infections had no statistically significant association with cervical cancer. >>>

Survey of surgeons’ and internists’ knowledge of colorectal cancer screening

Yaron Niv, MD, Galia Abuksis, MSc

The correct age range for screening was known by 43 to 76% of physicians, knowledge of the recommended procedure for the average risk population by 44 to 91%, and for high risk population by 22 to 94% of physicians. The signs and symptoms of colorectal cancer were known by 81 to 100%. Only 37% knew that the high-risk population includes a family history of ovarian cancer and 57% of physicians did not think that blood in the stool places a person at higher risk for colorectal cancer. >>>

The role of low-level magnification in visual inspection with acetic acid for the early detection of cervical neoplasia

Rengaswamy Sankaranarayanan, MD, Surendra S. Shastri, MD, Parthasarathi Basu, MD, Cédric Mahé, PhD, Ranajit Mandal, MD, Geethanjali Amin, DGO, Chinmayi Roy, MD, Richard Muwonge, MSc, Smriti Goswami, DGO, Pradip Das, DGO, Roshini Chinoy, MD, Lucien Frappart, MD, Sharmila Patil, MD, Devjani Choudhury, DGO, Titha Mukherjee, DGO, Ketayun Dinshaw, MD, FRCR

Of 16900 evaluable women, the detection of squamous cervical intraepithelial lesions by visual inspection with acetic acid (VIA) and low-level magnification (VIAM) was positive in 14.1 and 14.2% respectively. Combination of VIA and VIAM revealed a sensitivity of 58.1% and a specificity of 88.6%. >>>

Evaluation of CaDet, a computer-based clinical decision support system for early cancer detection: a comparison with the performance of clinicians

Israel Heller MD; Aharon Isakov MD; Yael Villa PhD; Haled Natour MD; Moshe Inbar MD; Jacob Fuchs MD; Sorela Blinder-Vayner MD; Itzhak Shapira MD; Marcel Topilsky MD

The performance of a computer program as a possible diagnostic aid to clinicians was evaluated for early cancer detection. Based upon the same patient information, the computer generated 416 cancer alerts, which significantly correlated with the cancer alerts that were raised by physicians. >>>

Bilateral oophorectomy and breast cancer risk reduction among women with a family history

Janet E. Olson, PhD; Thomas A. Sellers, PhD; Stephen J. Iturria, PhD; Lynn C. Hartmann, MDd

The protective effect of oopherectomy was stronger among women who were both premenopausal and less than age 50 at time of surgery and women in the highest risk groups experienced about one half to one fourth the number of cancers expected. >>>

Influence of direct referrals on time to diagnosis after an abnormal breast screening result

Kathleen M. Decker MHSA,; Marion Harrison MSc; Daniel Chateau PhD

The direct referral cohort completed the intervals between screening to first procedure, first procedure to diagnosis and screening to diagnosis significantly faster than the control or usual care cohorts. The diagnostic group of the direct referral cohort had a significantly shorter time from screening to first procedure while the breast health care group had a significantly shorter time from first procedure to diagnosis than all other cohort groups. The Manitoba breast-screening program reduced the time to the first procedure and the time to diagnosis. >>>

Glutathione S-transferase P1 Ile105Val polymorphism, cigarette smoking and prostate cancer

Gloria E. Mao PhD; Garret Morris BS; Qing-Yi Lu PhD; Wei Cao MD, PhD; Victor E. Reuter MD; Carlos Cordon-Cardo MD, PhD; Guido Dalbagni MD; Howard I. Scher MD; Jean B. deKernion MD; Zuo-Feng Zhang MD, PhD

In individuals with P1 Ile/ile genotype, the multiplicative interaction between glutathione -S-transferase and tobacco smoking was associated with an increased risk of prostate cancer (OR 4.09). Smoking (OR 1.55) and alcohol consumption (OR 2.91) were associated with a moderately increased risk while family history (OR 1.00) or dietary intake of high-fat foods (OR1.00) was not significantly associated with prostate cancer. >>>

Prostate cancer mortality in Connecticut, Iowa and New Mexico African American men

Luis G. Escobedo MD, MPH,; Saul D. Rivas BCH; Michelle D. Holmes MD, DrPH

After widespread use of PSA testing prostate cancer increased in Connecticut, Iowa and New Mexico. The least overall increase was observed for New Mexico. Mortality increased slightly in Connecticut and Iowa and decreased substantially in New Mexico. >>>


Herbert E. Nieburgs, MD
Worcester, MA