Cancer Detection and Prevention Volume 28 / Issue 4 (Jul-Aug 2004)

Table of Contents and Editor's Notes

The peer review process occasionally results in approval of controversial publications that do not necessarily reflect the viewpoint of the editors. Readers of the journal are encouraged to critically review and comment on presented data by submitting a "Letter to the Editor" that may be reprinted in a subsequent issue.

RET polymorphisms in codons 769 and 836 are not associated with predisposition to medullary thyroid carcinoma

Malgorzata Wiench, PhD,, Jan Wloch, MD, Zbigniew Wygoda, MD, Elzbieta Oubala, PhD, M. Oezko, A. Pawlaczek, D. Kula, D. Lange, MD , B. Jarzab, PhD

In 19 patients with medullary thyroid carcinoma, less than 30 yr of age, allelic frequencies of RET codon L769/CTG was 32 percent. For variant S836/AGT the frequency was 5 percent. In 58 patients older than 30 yr of age, the frequencies were 21 percent for variant L769/CTG and 3 percent for S836/AGT compared to 27 percent and 2 percent, respectively, in 90 controls. The differences were statistically not significant. >>>

Cyclin D1 A870G polymorphism and amplification in laryngeal squamous cell carcinoma: implications of tumor localization and tobacco exposure

Eurico Monteiro, MSc, Graça Varzim, MSc, Ana M. Pires, DSci, Manuel Teixeira, PhD, Carlos Lopes, PhD

In patients with squamous cell carcinoma of the larynx the cyclin D1 (CCND1) A870G genotype and allele frequencies did not differ significantly from healthy controls. There was no relationship between CCND1 genotype and disease stage, degree of tumor differentiation or recurrence. However, a significant difference existed between patients with glottic tumors and healthy individuals. >>>

Multi-target interphase fluorescence in situ hybridization assay increases sensitivity of sputum cytology as a predictor of lung cancer

Marileila Varella-Garcia PhDa,, John Kittelson PhDb, Aline P. Schulte BSa, Kieu O. Vu BSb, Holly J. Wolf PhD, Chan Zeng MSFred R. Hirsch MD Tim Byers MDTim Kennedy MDe, York E. Miller MD Robert L. Keith MDd, Wilbur A. Franklin MD

Chromosomal instability was assessed in interphase cells by a multi-target fluorescence in situ hybridization (FISH). Sputum cell atypia was present in 10 of 18 cases with a sensitivity of 0.56 and specificity of 0.80. Combined cytology and FISH was positive in 15 of 18 cases with a sensitivity of 0.83 and specificity of 0.80. >>>

p53 protein accumulation in colorectal cancer tissue has prognostic value only in left-sided colon tumours

Piotr Paluszkiewicza, MD, PhD, Henryk Berbeć, PhD, Barbara Pawlowska-Wakowicz, PhD, Marek Cybulski, MD, PhD, Alicja Paszkowska, PhD

The most frequent p53 protein accumulation was found in cells of rectal cancers (66.7%) compared to the right (42.9%) and left (33.3%) colon. The 10-year survival rate was equal to zero for patients with p53-positive left-sided colon cancers and 0.375 for p53-negative left-sided colon tumors, suggesting that TNM stages and p53 accumulation in cancer cells were significant prognostic factors for the left colon. >>>

Effect of physician recommendation and patient adherence on rates of colorectal cancer testing

P. Brawarsky, MPH, D.R. Brooks DSc, L.A. Mucci ScD, P.A. Wood MD

Differential rates of colorectal cancer testing were related to differences in physicians recommendations of tests and patients' adherence. Recommendations for FOBT (63%) were higher than for sigmoidoscopy (40%) or colonoscopy (27%). Overall, 84% of men and 71% of women adhered to a physician's recommendation for sigmoidoscopy. Strong recommendations were associated with adherence of 88% for men and 79% for women. >>>

Personal cancer prevention and screening practices among Asian Indian physicians in the United States

Ranjita Misra, PhD, CHES, Susan T. Vadaparampil, PhD, MPH

Asian-Indian physicians consumed to 2 to 4 daily servings of fruits: always (31%) and sometimes (45%). Exercise for at least 30 minutes on 5 or more days per week was reported by 34%. Sixty percent had a BMI of 18.5 to 25.0. Only 27%, aged 50 yr and older, had undergone a flexible sigmoidoscopy, and 25% had a FOBT. Approximately 87% of females reported having a PAP smear and 84% of female physicians over the age of 40 yr reported ever having a mammography. >>>

Rapid method for identification of chemopreventive compounds using multiplex RT-PCR for cyclooxygenase mRNA expression

Minnie Malik, PhD, Bernadene A. Magnuson, PhD

A rapid semi-quantitative multiplex RT-PCR was utilized for analysis for cyclooxygenase expression. Human HT-29 colon cancer cells (ATCC, HTB38) exposed to chokeberry ARE for 24h demonstrated decreased expression of COX-2 gene by 60 percent and COX-1 gene by 12%. Cells exposed to indomethethin had 25% inhibition of COX-1 expression and 20% of COX-2 expression. >>>

The activity of latent benzoperimidine esters to inhibit P-glycoprotein and multidrug resistance-associated protein 1 dependent efflux of pirarubicin from several lines of multidrug resistant tumor cells

Dorota Glowacka-Rogacka, M.Sc., Malgorzata Arciemiuk, Ph.D., Agnieszka Kupiec, M.Sc., Maria M. Bontemps-Gracz, Ph.D., Edward Borowski, Ph.D., Jolanta Tarasiuk, Ph.D., D.Sc.

Benzoperimidine esters (BPE3) inhibited P-glycoprotein and multidrug resistant protein (MRP1)-mediated pirarubicin efflux and restored its accumulation in MDR cells. >>>

Are there geographical differences in the frequency of SYT-SSX1 and SYT-SSX2 chimeric transcripts in synovial sarcoma?

Ira Koković MSc, Matej Bračko MD, PhD, Rastko Golouh MD, PhD, Marjolijn Ligtenberg PhD, Han J.J.M. van Krieken MD, PhD, Petra Hudler MSc, Radovan Komel PhD

The chromosomal translocation generated SYT-SSX2 fusion predominated in the Slovenian patients whereas SYT-SSX1 fusion prevailed in the Dutch group. There were no statistically significant differences between Slovenian and the Dutch groups in histologic subtype, patient's sex and age, tumor size, mitotic count and survival. >>>

Geographic pattern of cancers related to tobacco and alcohol in Connecticut: implications for cancer control

Anthony P. Polednak, PhD

In the state of Connecticut, the highest standardized rates (SIRs) for lung and oral cavity-pharynx cancers in males were found in the 4 largest towns: Bridgeport, Hartford, New Haven, Waterbury. Bridgeport and Hartford had statistically significantly elevated SIRs for esophageal cancer. In females, SIRs for lung cancer were not elevated, however, statistically significantly elevated SIRs were found for oral cavity-pharynx cancers in Hartford, New Haven and Greenwich. SIRs were highest in the towns's with the highest poverty-rate quartile. >>>


Herbert E. Nieburgs, MD
Worcester, MA