Cancer Detection and Prevention Volume 28 / Issue 3 (May-Jun 2004)

Table of Contents and Editor's Notes

The peer review process occasionally results in approval of controversial publications that do not necessarily reflect the viewpoint of the editors. Readers of the journal are encouraged to critically review and comment on presented data by submitting a "Letter to the Editor" that may be reprinted in a subsequent issue.

Factors affecting the incident juvenile bone tumors in an Austrian case­control study

Rainer Frentzel-Beyme, MD, Heiko Becher, PhD, Mechthild Salzer-Kuntschik, MD, Rainer Kotz, MD, Martin Salzer, MD

Interviews with 88 patients and controls revealed that measels and mumps were associated with increased risks for juvenile osteosarcoma, Ewing’s sarcoma and other bone tumors; chicken pox was related to a significant decrease; trauma and accidents had borderline significance. >>>

Hepatitis B testing among Vietnamese American men

Victoria M. Taylor, MD, MPH, Yutaka Yasui, PhD, Nancy Burke, PhD, Tung Nguyen, MD, Anthony Chen, MD, Elizabeth Acorda, BA, John H. Choe, MD, MPH, J. Carey Jackson, MD, MA, MPH

A high rate of hepatitis B virus (HBV) infection is attributed to the increased prevalence of liver cancer in Vietnamese American men. A questionnaire revealed that 96% of the survey participants believed that HBV could be treated better if detected early. An HBV educational progran led to serological testing for HBV in 66% of Vietnamese American men. >>>

Clinical significance of c-myc and p53 expression in head and neck squamous cell carcinomas

Angela F.L. Waitzberg, MD, PhD, Suely Nonogaki, BSc, Inês N. Nishimoto, MS, Luiz P. Kowalski, MD, PhD, Roberto E.V. Miguel, MD, PhD, Ricardo R. Brentani, MD, PhD, M.M. Brentani, MM, PhD

A moderate over-expression of c-myc was found in tumors of 36% of patients. In the normal adjacent mucosa, c-myc-positive nuclear staining was noted in 22.9% and cytoplasmic staining in 52.1%. P53 positivity was evident in 50.7% of tumors and in 20.7% of cells in the adjacent normal mucosa. There was no relationship of either p53 or c-myc expression with overall survival, but in patients with advanced stage tumors, the presence of p53 protein was associated with a shorter disease-free survival. Evidence of p53. >>>

N-acetyltransferase 2 (NAT2) genotypes, cigarette smoking, and the risk of breast cancer

Anthony J. Alberg, PhD, Alexander Daudt, MD, Han-Yao Huang, PhD, Sandra C. Hoffman, MPH, George W. Comstock, MD, Kathy J. Helzlsouer, MD, Paul T. Strickland, PhD, Douglas A. Bell, PhD

Carcinogenic aryl amines in cigarette smoke are detoxified by N-acetyltransferase-2 genotype through N-acetylation. Smoking of patients with low acetylators was associated with a nonsignificant increased risk for breast cancer, whereas in smokers with rapid acetylators the risk of breast cancer was nonsignificantly lower than in never smokers. >>>

DNA repair gene XRCC1 polymorphisms, smoking, and esophageal cancer risk

Hong-Ping Yu, MD, Ph.D, Xiao-Yong Zhang, MD, Xiao-Li Wang, MD, Lu-Yuan Shi, BS, Yuan-Yuan Li, MD, Fang Li, MD, Yan-Hua Su, MD, You-Jie Wang, MD, Ph.D, Bin Lu, MD, Ph.D, Xi Sun, MD, Ph.D, Wen-Hong Lu, BS, Shun-Qing Xu, MD, Ph.D

The X-ray repair cross-complementing 1 (XRCC1) genetic polymorphism at codon 194 was not associated with risk for esophageal squamous cell carcinoma (ESCC). However, the frequency of XRCC1 399 Gln/Gln genotype in ESCC patients (14.1%) was significantly higher than in normal controls (3.3%) and was associated with a 4.2-fold risk increase for ESCC smokers. >>>

13-cis-Retinoic acid ameliorates benzoyl peroxide-induced oxidative stress and hyperproliferative response in murine skin: a chemopreventive study

Sarwat Sultana, PhD, Aftab Alam, PhD, Sonia Sharma, MSc, Naghma Khan, MSc

Pretreatment of mice skin with 13-cis-retinoic acid prior to application of benzoyl peroxide led to recovery in levels of the antioxidant enzymes, glutathione and its metabolizing enzymes. >>>

Decreased interleukin-1 receptor antagonist response following moderate exercise in patients with colorectal carcinoma after primary treatment

Hubert Allgayer, MD, Susanne Nicolaus, MD, Hans-Joachim Grupp, MD, Stephan Schreiber, MD

In patients with curatively treated colorectal cancer, a short-term rehabilitaiton program with moderate exercise (ME) yielded beneficial effects in terms of antiinflammatory response with resistance to infection and with a decreased relative risk of cancer. Lipopolysaccharide-stimulated IL6 production was found to be signicantly higher in patients in the ME group compared to the low exercise group. >>>

Apoptosis in Hep2 cells treated with etoposide and colchicine

Miroslav Cervinka, MD, PhD, Jaroslav Cerman, MD, PhD, Emil Rudolf, PhD

Hep2 cells of a human laryngeal epitheliod cell line treated with two apoptosis-inducing chemicals, etoposide and colchicine, resulted in disappearance of nuclear density, sudden loss of adherence and formation of blebs followed by subsequent cell swelling and fragmentation. It appeared that microfilaments (actin) and not microtubules (tubulin) were involved in the formation of blebs. >>>


Herbert E. Nieburgs, MD
Worcester, MA