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Published in Cancer Detection and Prevention 2004; 28(2):94-098.

The relationship between endometrial carcinoma and coexistent adenomyosis uteri, endometriosis externa and myoma uteri

Masafumi Koshiyama, MD, Takako Okamoto, Michio Ueta

Department of Obstetrics and Gynecology, Himeji National Hospital, 68, Honmachi, Himeji City, Hyogo 670-8520, Japan

The relationship between endometrial carcinoma and coexistent adenomyosis uteri, endometriosis externa and myoma uteri has been reported in only a few studies. We studied the characteristics of the endometrial carcinomas accompanied by these benign diseases. The total number of endometrial carcinoma cases was 179, consisting of 29 (16%) endometrial carcinomas with adenomyosis uteri, 12 (7%) with endometriosis externa, 51 (28%) with myoma uteri, and 87 controls (49%) without these benign diseases. Seventy-nine, 75, and 65% of the endometrial carcinomas with adenomyosis uteri, endometriosis externa and myoma uteri, respectively, showed a low histologic grade (G1). In particular, the patients with adenomyosis uteri and endometriosis externa were relatively younger than the control patients (54.2, 54.1 years old versus 57.7 years old). Furthermore, these patients were all treated at stage 1 and had a good prognosis. In brief, there are some different clinicopathologic differences between the endometrial carcinoma cases with benign hormone-dependent disease and the cases without these disease.

KEY WORDS: Endometrial carcinoma, Adenomyosis uteri, Endometriosis externa, Myoma uteri, Endometrioid adenocarcinoma, Nonendometrioid carcinoma.

http://www.cancerprev.org/Journal/Issues/28/2/4867