Cancer Detection and Prevention Volume 27 / Issue 3 (May-Jun 2003)

Table of Contents and Editor's Notes

The peer review process occasionally results in approval of controversial publications that do not necessarily reflect the viewpoint of the editors. Readers of the journal are encouraged to critically review and comment on presented data by submitting a "Letter to the Editor" that may be reprinted in a subsequent issue.

Regulatory CD8⁺ T cells control thyrotropin receptor-specific CD4⁺ clones in healthy subjects

Monica Molteni, Carlo Rossetti, Santo Scrofani, Paola Bonara, Raffaella Scorza and Leonard D. Kohn

In healthy subjects a subset of non-cytotoxic CD8⁺ CD28^- T cells suppressed the specific response to the thyrotropin receptor (TSHR) of CD4⁺ clones. Co-incubation of CD⁺ and CD4⁺ demonstrated after removal of CD8⁺ cells that responsiveness of CD⁺ cells to TSHR was low with a significant impairment of IL-2 production. >>>

Scaffold attachment region located in a locus targeted by hepadnavirus integration in hepatocellular carcinomas

R. Bruni M.Sc., E. D'Ugo M.Sc., C. Argentini M.Sc., R. Giuseppetti BS and M. Rapicetta Ph.D.

Fragments cloned from normal liver tissue indicated presence of either nuclear scaffold or nuclear matrix attachment regions (S/MAR) located between 2500-3000 nucleotide positions of the b3n sequence. The b3n locus of the woodchuck genome targeted by woodchuck hepatitis virus (WHV) integration in liver tumors was shown to harbor a 0.5kb region showing several sequence features with known S/MAR elements. >>>

Serum p53 antibodies in correlation to other biological parameters of breast cancer

S. Sangrajrang PhD, W. Arpornwirat MD, A. Cheirsilpa MD, P. Thisuphakorn MD, A. Kalalak MD, A. Sornprom MD and T. Soussi PhD

In cases of invasive ductal carcinoma a highly significant association was found between p53 accumulation and presence of p53 antibodies (p53-Abs). A statistically significant relationship was noted between the presence of p53-Abs and local-regional lymphnode involement. >>>

Occupational physical activity and the risk of breast cancer

Joanna Kruk and Hassan Y. Aboul-Enein

Women less than 55 years of age in sedentary occupation had a 29% higher risk of breast cancer compared to women of medium activity. High levels of occupational physical activity throughout life reduced the risk of breast cancer by 50-60%. >>>

Enhancing the efficacy of chemotherapeutic drugs by the suppression of antiapoptotic cellular defense

T. Minko PhD, S.S. Dharap BS, A.T. Fabbricatore PhD

The combination of apoptosis inductor doxorubicin (DOX) with a suppressor of antiapoptotic cellular defense BCL-2 homology 3 (BH3) peptide significantly enhanced the toxicity of DOX. >>>

Cervical cancer mortality among foreign-born women living in the United States, 1985 to 1996

Laura C. Seeff MD and Matthew T. McKenna MD MPH

Cervical cancer mortality rates in the US, from 1985 to 1986, were increasingly higher for foreign-born than US-born women. In view of these results, the interpretation of US cervical cancer mortality should include an evaluation of mortality in the foreign born community. >>>

DNA adducts detected in human gastric mucosa

Mohammed Abdul Momen MD, Yasumasa Monden MD, PhD, Kunimi Hamada MD, PhD, Kansei Komaki MD, PhD, Kazuya Kondo MD, PhD and Atsushi Umemoto MD, PhD,

In patients with gastrointestinal neoplasms, common background DNA adducts were detected in both the mucosa and muscle layer. The mucoas-specific adducts, though present in the gastric mucosa were absent in the mucosa adjacent muscle layer. >>>

Codon 201 polymorphism of DCC gene is a prognostic factor in patients with colorectal cancer

Hong Zhang MD PhD , Gunnar Arbman MD PhD , and Xiao-Feng Sun MD PhD

The polymorphism at codon 201 was common in poorly differentiated tumors and was related to an expansive growth pattern rather than to an infiltrative growth pattern. Patients with polymorphism Arg/Gly or Gly/Gly had a worse prognosis of survival compared to patients with codon 201 Arg/Arg. Loss of heterzygosity was not related to prognosis. >>>

Comparative analysis of G2 arrest after irradiation with 75 keV carbon-ion beams and 137Cs -rays in a human lymphoblastoid cell line

Satoko Matsumura PhD , Tatsushi Matsumura PhD , Shuji Ozeki MSc , Shoko Fukushima MD , Hideya Yamazaki PhD , Takehiro Inoue PhD , Toshihiko Inoue PhD , Yoshiya Furusawa PhD and Kiyomi Eguchi-Kasai PhD

The division delay of cell populations that were exposed to carbon-ion beams was approximately 16-24h longer than after use of gamma-rays. Carbon-ion beam irradiation resulted in longer G2 delay than gamma-ray irradiation. >>>

Anti-angiogenesis and angioprevention: mechanisms, problems and perspectives

D. Bisacchi PhD , R. Benelli PhD , C. Vanzetto , N. Ferrari PhD , F. Tosetti PhD and A. Albini PhD

This extensive review deals with angiogenesis in tumor progression and metastasis and anti-angiogenesis inhibitors. Topics covered include pro-angiogenic mechanisms, natural inhibitors of angiogenesis, anti-angiogenic cancer therapy and angiogenesis inhibitors of chemoprevention. >>>

Herbert E. Nieburgs, MD
Worcester, MA
2003