Cancer Detection and Prevention Volume 27 / Issue 1 (Jan-Feb 2003)

Table of Contents and Editor's Notes

The peer review process occasionally results in approval of controversial publications that do not necessarily reflect the viewpoint of the editors. Readers of the journal are encouraged to critically review and comment on presented data by submitting a "Letter to the Editor" that may be reprinted in a subsequent issue.

Modulation of interleukin-8 and nitric oxide synthase mRNA levels by interferon-gamma in macrophages stimulated with ligniin derivatives and lipopolysaccharides

K Sorimachi PhD, K Akimoto PhD, S Yamazaki PhD

In macrophages stimulated by lignin derivatives (EP3) or lipopolysaccharides (LPS) INFγ slightly increased the INFα mRNA level and failed to induce significantly IL-8mRNA expression. In stimulated macrophages, INFγ markedly increased the level of TNF-α mRNA and reduced the level of IL-8 mRNA in a dose-dependent manner. >>>

Mitochondrial damage leads to apoptosis in furanonaphthoquinone treated lung cancer cells

E Simamura MHE, K Hirai PhD, H Shimanda PhD, J Pan PhD, J Koyama PhD, K Watanabe MD PhD

Application of 2-methylnapthol in [2-3-b]furan-4,9 dione (FNQ3) to human lung adenocarcinoma cells A549 caused H202 production prior to mitochondrial swelling and induction of apoptosis. >>>

The Efficacy of a Serum Carboxyterminal Pyridinoline Cross-linked Telopeptide of Type 1 Collagen as a Quantitative Screening Marker for Bone Metastases in Patients with Urological Malignancies

T Okamura MD PhD, H Akita MD PhD, H Tatsura MD PhD, N Kawai MD, D Nagata MD, M Azemoto MD, Y Iwase MD PhD, K Kohri MD PhD

Serum telopeptide of type-I collagen (ICTP) was significantly elevated in cases of metastases from prostate, renal and other urothelial cancers. >>>

Microsatellite dinucleotide (T-G) repeat: a candidate DNA marker for breast metastasis

B Mukherjee, PhD, H Zhao, PhD, B Parashar, MD, BM Sood, MD, PS Mahadevia, MD, HP Klinger, MD PhD, B Vikram, MD, MP Achary, PhD

A novel metastasis associated DNA gene sequence (MADS-1) in microdissected cells was absent in 80% of metastatic cell DNA samples from primary ductal cell carcinoma and corresponding positive lymph nodes. However, it was present in 100% of cells from normal tissue of the same patient. >>>

Relationship between DNA repair capacity and resistance to genotoxins in four human cell lines

BS Atanassov, PD Ninova, BB Anachkova, PhD, GC Russev, PhD

Four human cell lines, k562/myeloid leukemia, Namalwa/Burkitt lymphoma, HeLa cells/cervical carcinoma, and HEK293 from embryonic kidney epithelium were assessed for their sensitivity towards cytotoxic drugs and their capacity for DNA repair. Cell line k562 had the highest and HeLa cells the lowest survival rates. Namalwa and HEK293 cells had intermediate values. >>>

Evaluation of familial clustering of breast and prostate cancer in the Minnesota breast cancer family study

DM Grarbrick PhD, JR Cerham MD, PhD, RA Vierkant MAS, TM Therneau, PhD, JC Cheville MD, DJ Tindall PhD, TA Sellers PhD

Male blood relatives of high-risk breast-ovarian cancer families appeared to be at decreased rather than increased risk of prostate cancer. There was no association between family history of breast breast-ovarian cancer and cancer in general in the male relatives. >>>

Supression of mammary gland tumorigenesis in diabetic rats

C Cocca MSc, A Gutierrez MSc, Mariel Nunez Msc, M Croci MD, G Martin PhD, G Cricco PhD, E Rivera PhD, R Bergoc PhD

Diabetes was induced in rats by streptozotocin (STZ) and mammary tumors by N-nitroso-N-methylurea (NMU). STZ/NMU-treated rats had a significantly longer latency period than non-diabetic NMU-treated rats. In the STZ/NMU-treated rats, the number of tumors per animal was significantly lower than in non-diabetic NMU-treated rats. In the STZ/NMU-treated rats, 84% of tumors were benign whereas in in non-diabetic NMU-treated rats 100% of tumors were malignant. >>>

The MTS assay as an indicator of chemosensitivity / resistance in malignant gynaecological tumours

SA O'Toole MSc, BL Sheppard PhD, JB Bonnar MD, EPJ McGuinness MD, NC Gleeson MD, M Yoneda MD

The dimethylthiazol-tetrazolium-salt cytotoxicity assay for response of endometrial and cervial tumor chemotherapy drugs cis-platin, taxol, hycamtin and 5-fluorouracil was retrospectively correlated with clinical outcome. In vitro sensitivity had 87% predictive accuracy while in vitro resistance had 93% predictive accuracy. >>>

Specific Fatty Acids and Human Colorectal Cancer: An Overview

A Nkondjock MSc, PhD candidate, B Shatenstein PhD, P Maisonneuve PhD, P Ghadirian PhD

Evidence is presented that dietary fats may influence the development of colorectal cancer. Increased consumption of short-chain fatty acids (SCFAs) almost entirely in dairy products and eicosanopentaenoic acid (EPA) in fish oil appear to protect against colorectal cancer. Conversely, increased intake of medium-chain fatty acids (MCFAs) present in coconut oil and arachidonic acid in sardine oil seems to be associated with increased. >>>

Boswellic acid acetate induces differentiation and apoptosis in highly metastatic melanoma and fibrosarcoma cells

W Zhao PhD, F Entschladen PhD, H Liu BS, B Niggemann MD, Q Fang PhD, KS Zaenker MD, R Han MD.

Growth inhibition activity of Boswellic acid acetate (BC-4) was determined by the dimethylthiazole diphenyl tetrazolium bromide (MTT) assay. The cytostatic compound BC-4 inhibited the growth B-16F10 mouse melanoma cells in culture and induced differentiation and apoptosis in human fibrosarcoma cells HT-1080. >>>

Effects of hyperthermia and differentiation on cultured Dunn osteosarcoma cells

M Kanamori MD, K Ohmori MD, T Yasuda MD, K Yudoh MD

Application of heat (42 degrees C 1h/24h) to Dunn osteosarcoma cells changed the morphology of clumps of spindle and ovoid shaped cells with several nucleoli to a fibroblast-like appearance of cells with long and thin protoplasmic processes. Heat produced also a reduction in DNA synthesis and a decrease in the number of AgNORs per cell. >>>


Herbert E. Nieburgs, MD
Worcester, MA