Cancer Detection and Prevention Volume 26 / Issue 6 (Nov-Dec 2002)

Table of Contents and Editor's Notes

The peer review process occasionally results in approval of controversial publications that do not necessarily reflect the viewpoint of the editors. Readers of the journal are encouraged to critically review and comment on presented data by submitting a "Letter to the Editor" that may be reprinted in a subsequent issue.

Pharmacogenomics in cancer drug discovery and development: inhibitors of the Hsp90 molecular chaperone

Paul Workman

The rationale for an anticancer effect of chaperone inhibition, and progress in drug development are reviewed. The Hsp90 chaperone is required for correct folding and stability of a range of oncogenes and thus its inhibition provides a means of blocking a wide range of cancer pathophysiologies. >>>

Modification of lung cancer susceptibility by green tea extract as measured by the comet assay

Huifeng Zhang, MD, Margaret R. Spitz, MD, MPH, Gail E. Tomlinson, MD, PhD, Matthew B. Schabath, MS, John D. Minna, MD, Xifeng Wu, MD, PhD

Carcinogen-induced DNA damage is prevented by green tea extract at relatively low doses. A fascinating finding is that lymphoblastoid cells from cancer patients not previously treated with chemotherapy or radiation are more sensitive to carcinogen-induced DNA damage than lymphoblastoid cells from normal patients, suggesting that cancer risk should be able to be predicted with the comet assay. >>>

Chemopreventive effect of farnesol and lanosterol on colon carcinogenesis

Chinthalapally V. Rao, DVM, PhD, Harold L. Newmark, DVM, PhD, Bandaru S. Reddy, DVM, PhD

Farnesol and lanosterol abrogate carcinogen-induced aberrant colonic crypt focus formation in rats. >>>

Allelic loss in breast cancer (review)

Spiros Miyakis, MD, PhD, Demetrios A. Spandidos, PhD, DSc

The genetic basis for allelic loss and its correlations with clinical and morphological features of breast cancer are comprehensively reviewed. >>>

Transcriptional control of the RECK metastasis/angiogenesis suppressor gene

Regina Maki Sasahara, PhD, Sheila Maria Brochado, BS, Chiaki Takahashi, MD,PhD, Junseo Oh, PhD, Silvya Stuchi Maria-Engler, PhD, José Mauro Granjeiro, PhD, Makoto Noda, PhD, Mari Cleide Sogayar, PhD

The role RECK in suppressing metastasis and angiogenesis, and the mechanism of its transcriptional down-regulation by Ras and the Ras-responsive transcription factors Sp1 and Sp3 are reviewed. >>>

Differential expression of DNA-methyltransferases in drug-resistant murine neuroblastoma cells

Y-Yong Qiu, MD, Bernard L. Mirkin, PhD,MD, Rama S. Dwivedi, PhD

Chemotherapy resistance is associated with increased expression of two DNA methyltransferases, along with an increase in global DNA methylation, suggesting that genes conferring chemosensitivity could be inactivated by DNA methylation. >>>

Close correlation between restriction fragment length polymorphism of L-myc gene and susceptibility to gastric cancer

Turgay Isbir, PhD, Ilhan Yaylim, PhD, Soykan Arikan, MD, Esra Kaytan, MD, Tamer Karşidağ, MD, Savaş Bayrak, MD, Hakan Çamlica, MD

Gastric cancer patients have significantly higher heterozygosity for L-myc long and short alleles (72%) compared to a control group (35%), with an overall higher frequency of the short allele in the gastric cancer population. >>>

Gene gun-mediated intracutaneous vaccination with papillomavirus E7 gene delays cancer development of papillomavirus-induced skin papillomas on rabbits

Ricai Han, PhD, Xuwen Peng, PhD, Cynthia A. Reed, BA, Nancy M. Cladel, MSc, Lynn R. Budgeon, HT, Martin D. Pickel, PhD, Neil D. Christensen, PhD

Intradermal DNA vaccination with E6 is ineffective, whereas E7 vaccination decreases the time to progression to carcinoma from cottontail rabbit papillomas. >>>

A novel syngeneic murine model for thoracic neuroblastoma obtained by intramediastinal injection of tumor cells

Maria V. Corrias, PhD, Paola Bocca, MS, Emanuela Anelli, MS, Michele Cilli, DVM, Marzia Occhino, PhD, Vito Pistoia, MD, Claudio Gambini, MD

The dissemination of neuroblastoma differs depending on whether tumor is inoculated into the mediastinum, retroperitoneum or tail vein. >>>


Herbert E. Nieburgs, MD, Andrew Fischer, MD
Worcester, MA