Cancer Detection and Prevention Volume 26 / Issue 5 (Sep-Oct 2002)

Table of Contents and Editor's Notes

The peer review process occasionally results in approval of controversial publications that do not necessarily reflect the viewpoint of the editors. Readers of the journal are encouraged to critically review and comment on presented data by submitting a "Letter to the Editor" that may be reprinted in a subsequent issue.

Simultaneous detection of the tumor suppressor FHIT gene and protein using the multi-functional biochip

Minoo D.F. Askari PhD, Gordon H. Miller MS, Tuan Vo-Dinh, PhD

The fluorescent multi-functional biochip for simultaneous detection of FHIT DNA and FHIT protein permits proteomic assays by direct measurements of various antigen-antibody complexes and double-stranded DNA formations that are involved in carcinogenic manifestations. >>>

Loss of heterozygosity at loci of candidate tumor suppression genes in microdissected primary non-small cell lung cancer

WH Ho MD, JW Chang MS, RC Tseng MS, JT Chen MD, CY Chen MD, YS Jou PhD, YC Wang PhD

In non-small cell lung cancer, loss of heterozygosity (LOH) in chromosomal regions containing tumor suppressor genes (p53 and VHL) was significantly higher in squamous cell carcinoma than in adenocarcinoma. It was frequently higher in patients who smoke than in nonsmoker patients. Patients with LOH had significantly longer survival times compared to those without LOH. >>>

Evidence-based policy recommendations on cancer screening and prevention

Eduardo L. Franco, DrPH, Eliane Duarte-Franco, MD, MPH, Thomas E. Rohan, MD, PhD

This extensive review summarizes the practice guidelines for cancer prevention based on the recommendations and policies on screening and prevention of specific types of cancer issued by international and North American health agencies and professional groups. >>>

Early detection of cancer: knowledge and behavior among Dutch adults

Jascha de Nooijer, MPH, Lilian Lechner, PhD, Hein de Vries, PhD

Written questionnaires were employed to ascertain knowledge of detection methods and cancer symptoms, recognition of symptoms, detection behaviors and health-seeking behaviors in Dutch adults. Responders had poor general knowledge of detection methods and cancer symptoms. Women were more aware of cancer symptoms than men. An outcome of the study was the recommendation for health education that separates the internal from external symptoms of cancer. >>>

A proposed mechanism of tamoxifen in breast cancer prevention

Fu-Li Yu, PhD , B.S. Wanda Bender

Tamoxifen inhibited the formation of 17beta-estradiol (E2) and estrone (E1) epoxides as measured by both the loss of their ability to inhibit nuclear DNA-dependent RNA synthesis and to bind to DNA. >>>

Glutathione S-transferase GSTP1 genotypes are associated with response toandrogen ablation therapy in advanced prostate cancer

CJ Luscombe FRCS, ME French MD, S Liu FRCS, MF Saxby MD, WE Farrell PhD, PW Jones PhD, AA Fryer PhD, RC Strange PhD

In patients with advanced prostate cancer receiving androgen ablation therapy, glutathione S-transferase (GSTP1) frequency was significantly higher in 86 of 118 patients who demonstrated a good response than in those with poor prognosis. The GSTP1 was not associated with tumor grade or metastatic state. >>>

Dietary factors affecting uterine weights of immature CD-1 mice used in uterotrophic bioassays

Julius E. Thigpen, PhD, Joseph K. Haseman, PhD, Hannah Saunders, BS, Jacqueline Locklear, DVM, Gordon Caviness, BS, Mary Grant, VMD, Diane Forsythe, DVM

An uterotrophic bioassay is evaluated for determining estrogenic or antiestrogenic activitity of endocrine disruptor compounds In this study to assess chemical and phytoestrogen in rodent diets, metabolizable energy in natural ingredient or purified diets had a significant effect on the uterine weight of immature mice. >>>

Evaluation of a "loss-framed" minimal intervention to increase mammography utilization among medically un- and under-insured women

Doris A. Abood, EdD, CHES, Daniel C. Coster, PhD, Ann K. Mullis, PhD, David R. Black, PhD, HSPP, CHES, MPH, FASHA, FSBM, FAAHB

The styles of telephone messages for mammogram appointments were evaluated. Women who were informed about the possible negative outcome of neglecting the opportunity for early detection and the risk of developing breast cancer were 6 times more likely to obtain a mammogram than those who received the usual telephone or "gain-framed" message of benefits. >>>


Herbert E. Nieburgs, MD
Worcester, MA