Cancer Detection and Prevention Volume 26 / Issue 4 (Jul-Aug 2002)

Table of Contents and Editor's Notes

The peer review process occasionally results in approval of controversial publications that do not necessarily reflect the viewpoint of the editors. Readers of the journal are encouraged to critically review and comment on presented data by submitting a "Letter to the Editor" that may be reprinted in a subsequent issue.

Genomics and proteomics: application of novel technology to early detection and prevention of cancer

Chad M Michener, MD, Ali M Ardekani, PhD, Emmanuel F Petricoin III, PhD, Lance A Liotta, MD PhD, Elise C Kohn, MD

Genomic alterations in a variety of tumors may be identified by techniques such as loss of heterozygosity, screening and comparative genomic hybridization. Proteomic profiling permits assessment of disease progression and pathway activation in prostate and esophageal cancer specimens. Combined evaluation of genomics and protemics may lead to earlier detection, improved prevention and molecular tumor-specific treatment of individual cancer patients. >>>

Effects of native and cleaved forms of α1-antitrypsin on ME 1477 tumor cell functional activity

Inga Zelvyte, MD, Hans-Olov Sjogren, MD, Sabina Janciauskiene, PhD

C-terminal fragments of a-1-antitrypsin (AAT) added to mouse melanoma cells ME1477 stimulated matrix metalloproteinase (MMP) activity and increased cell growth while the native form of AAT resulted in reduction of tissue inhibitor MMP and decrease of cell proliferation. >>>

An integrative model on the role of DMBT1 in epithelial cancer

Jan Mollenhauer, PhD, Burkhard Helmke, MD, Hanna Muller, MD, Gaby Kollender, BSc, Inge Krebs, PhD, Stefan Wiemann, PhD, Uffe Holmskov, PhD, Jens Madsen, BSc Herwart F. Otto, MD, Annemarie Poustka, PhD

The scavenger receptor cysteine-rich gene deleted in malignant brain tumors (DMBT1) and epithelial cancers has a dual function. The muscin-like DMBT1 produced tissue-specific expression and secretion in monolayered epithelia and differentiation in multi-layered epithelia. >>>

Vector-based delivery of tumor-associated antigens and T-cell co-stimulatory molecules in the induction of immune responses and anti-tumor immunity

James W Hodge, PhD; Douglas W Grosenbach, PhD; Jeffrey Schlom, PhD

This extensive review is focused on (a) the use of recombinant poxvirus vectors for delivery of tumor-associated antigens and other immune stimulatory molecules to the immune system; (b) use of diversified prime and boost strategies of different vaccines; and, (c) the role and limits of T-cell co-stimulation in activation of T cell responses. Specific information is provided on T-cell immunity, T-cell co-stimulation, murine carcinoma cells MC38 infected with a triad of co-stimulating molecule vectors (TRICOM), dendritic cells, and non-dendritic antigen-presenting cell studies. In vivo observations showed longer survival of mice receiving recombinant CEA vaccines and cytokines compared to mice that received control vectors along with cytokine treatment. >>>

Cytokine network in autoimmune haemolytic anaemia: new probable targets for therapy

C Toriani-Terenzi MD, U Pozzetto, M Bianchi, E Fagiolo MD

In patients with autoimmune hemolytic anemia (AIHA) the proliferative response of peripheral blood mononuclear cells in culture was increased compared to controls. In unstimulated cultures, IL10, IL 12 and Th2-type cytokine production was greater than in controls. Patients with untreated AIHA had increased basal synthesis of IL4 and decreased levels of interferon-gamma in comparison to controls. >>>

Efficient intracellular delivery of 5-fluorodeoxyuridine into colon cancer cells by targeted immunoliposomes

Gerben A Koning PhD, Jan AAM Kamps PhD, Gerrit L Scherphof PhD

The immunoliposome incorporated drug FudR-dP was delivered intracellularly to CC531 colon cancer cells. After a 72-hr incubation period, free FudR effectively inhibited tumor cell growth. >>>

Potential role of lipid peroxidation-derived DNA damage in human colon carcinogenesis: studies on exocyclic base adducts as stable oxidative stress markers

Helmut Bartsch, PhD, Jagadeesan Nair, PhD

The formation of markedly increased etheno adduct levels was noted in affected colon epithelium from patients with ulcerative colitis, Crohn disease and familial adenomatous polyposis compared to asymptomatic colon tissue and sporadic colon cancer. >>>

DNA-analysis of cholangiocarcinoma cells: prognostic and clinical importance

Hassan Abou-Rebyeh, MD, Hussain Al-Abadi, MD, Sven Jonas MD, Ikonja Rotter CTIAC, Wolf O Bechstein MD, Peter Neuhaus MD

Seventy-five percent of patients with resected DNA diploid cholangiocarcinoma survived more than three years. In contrast, only 21 percent of patients with aneuploid cholangiocarcinoma after resection survived more than three years and 79 percent of patients died within 1.7 years. >>>

Evaluation of an outreach intervention to promote cervical cancer screening among Cambodian American women

Victoria M Taylor, MD MPH, J Carey Jackson, MD MPH, Yutaka Yasui, PhD, Alan Kuniyuki, MS, Elizabeth Acorda, BA, Ann Marchand, BA, Stephen M Schwartz, PhD, Shin-Ping Tu, MD MPH, Beti Thompson PhD

The evaluation of a cervical cancer screening intervention program targeting Cambodian-American women revealed that PAP testing in the prior 12 months significantly increased similarly in the intervention and control group, possibly as a result of general awareness about the project among women and health care providers. >>>

Herbert E. Nieburgs, MD
Worcester, MA
2002