Cancer Detection and Prevention Volume 26 / Issue 3 (May-Jun 2002)

Table of Contents and Editor's Notes

The peer review process occasionally results in approval of controversial publications that do not necessarily reflect the viewpoint of the editors. Readers of the journal are encouraged to critically review and comment on presented data by submitting a "Letter to the Editor" that may be reprinted in a subsequent issue.

Targeting multiple genetic aberrations in isolated tumor cells by spectral fluorescence in situ hybridizations

ML Slovak PhD , F Zhang MS , L Tcheurekdjian BS , D Bobadilla BS , V Bedell BS , DA Arber MD , DL Persons MD , JA Sosman MD , JL Murata-Collins PhD

Use of spectral fluorescence in situ hybridization (S-FISH) for identification of genetic aberrations may contribute substantially to determination of tumor subtype, detection of residual disease and disease progression. >>>

Mammography screening and breast cancer biology in African American women - a review

R Royak-Schaler PhD, DP Rose MD PhD

Late-stage diagnoses of breast cancer in African-American (AAs) women may be reduced by screening at frequent intervals. Cancers are less likely to be steroid receptor positive and more likely to have a higher S phase fraction and more often poorly differentiated than in white American women. AAs have a higher risk of ductal carcinoma in situ, microcalcifications and mammographic densities. >>>

Mastalgia and breast cancer: a protective association

Seema A Khan MD , A Vania Apkarian PhD

Women complaining of mastalgia were less likely to be diagnosed with breast cancer than women who did not complain of breast pain regardless of age and other breast cancer risk factors, with the exception of those using alcohol. >>>

Use of Medicare claims data to measure county-level variation in breast carcinoma incidence and mammography rates

GS Cooper MD , Z Yuan MD PhD , RN Jethva BA , AA Rimm PhD

Residents of the most impoverished areas were more than twice as likely to be a hospital emergency admission, less likely to receive surgical intervention, and less likely to be treated in a specialized cancer center. Among the counties, a more than 2-fold variation was documented in breast carcinoma incidence and mammography rates. Mammography use correlated with cancer incidence. >>>

Breast and cervical cancer screening among migrant and seasonal farmworkers: a review

Steven S Coughlin PhD, Katherine M Wilson MPH

Published studies indicate a lack of knowledge about the causes and early treatment of cancer, as well as fatalistic attitudes toward the disease. Barriers to physical examinations, obtaining Pap test and mammography included cost, time constraints, long work days, lack of transportation, fear of the disease, suffering, embarrassment and shame about physical examination of breast and cervix. >>>

Intermittent, repetitive administrations of irinotecan (CPT-11) reduces its side-effects

H Fujii MD , M Koshiyama MD , M Konishi MD , M Yoshida MD , K Tauchi MD

Switching to an every 10-day schedule of the topoisomerase 1 inhibitor, irinotecan, with antitumor activity and the addition of G-CSF and baicalin significantly reduced the incidence of leukopenia and diarrhea in the treatment of refractory or recurrent ovarian carcinomas. >>>

Expression of manganese superoxide disumutase influences of chemo-sensitivity in esophageal and gastric cancers

R Izutani MD, M Kato MD, S Asano MD, M Imano MD, H Ohyanagi MD

TNF alpha increased manganese superoxide dismutase (MnSOD) while TGF beta decreased MnSOD. Sensitivity to adriamycin correlated inversely with MnSOD levels supporting a model in which adriamycin cytotoxicity depends on free radicals. >>>

Stromelysin-2 overexpression in human esophageal squamous cell carcinoma: potential clinical implications

Robin Mathew, PhD , Rinu Khanna, MSc , Rajesh Kumar, MSc , Meera Mathur, PhD , Nootan K. Shukla, MD , Ranju Ralhan, PhD

Stromelysin-2 expression was associated with local invasion, large tumor size and distant metastasis. >>>

Inhibition of nuclear factor KB induces apoptosis following treatment tnf-alpha and an antioxidant in human prostate cancer cells

Kushlani Gunawardena PhD, Darrell K. Murray PhD, Richard E. Swope DDS; A. Wayne Meikle MD

Antioxidant treatment reduced cell growth of two prostate cancer cell lines and was associated with decreased cytoplasmic NF kappa beta translocation to the nucleus, and with reduced expression of the apoptosis gene c-IAP2 inhibitor. >>>

Cyclo-oxygenase-2 expression in primary cancers of the lung and bladder

CJ Sweeney MD , MS Marshall PhD , DS Barnard BS , DK Heilman BS , SD Billings MD , L Cheng MD , SJ Marshall , MT Yip-Schneider PhD

Cyclo-oxygenase-2 (COX-2) protein expression was increased in lung and bladder carcinoma without correlation to BCL-2 levels. COX-2 in histologically normal-appearing adjacent tissue may be involved in early cellular changes leading to the development of lung and bladder cancer. >>>


Herbert E. Nieburgs, MD, Andrew Fischer, MD
Worcester, MA