Published in Cancer Detection and Prevention 2002; 26(2).

Active and passive smoking, high-risk human papilloniaviruses and cervical neoplasia

Ann L. Coker, PhD a, Sharon M. Bond, CNM, MSN b. Avis Williams, MSPHa, Tsilya Gerasimova, PhDc, Lucia Pirisi. MDc

a Department of Epidemiology and Biostatisics, University of South Carolina. Columbia, SC. USA b School of Nursing, Medical University of South Carolina, Charleston, SC, USA cDepartment of Pathology, School of Medicine, Universlty of South Carolina, Columbia, SC. USA

Accepted 11 January 2002

Few studies have cvaluatcd thc role of passive smoke exposure and cervical ncoplasia risk. We assessed the role of active and passive cigarette Smoke exposure and risk of cervical squamous intraepithelial lesion (SIL) in a case-control study based in a South Carolina Health Deparbnent; 59 high-grade SIL (HSIL) cases, 313 low-grade SIL (LSlL) cases and 427 controls recruited and interviewed. Passive cigarette smoke exposure was significantly (P < 0.05) associated with high grade SlL (adjusted odds ratio (aOR) = 2.2) and low-grade (aOR = 1.4). Activc smoking was associated with SIL only among White women (aOR = 1.8). High-risk human papillomaviruses (HR-HPVs) appear to interact with active cigarette smoking to increase HSIL risk. HSIL cases compared with LISL cases were significantly more likely to be HR-HPV positive current smokers (aOR = 3.0; 95% CI: (1.2, 7.7)). These data suggest that active and perhaps passive smoke exposure may be important co-factors in HSIL, development among HR-HPV positive women.

KEY WORDS: Cervical neoplasms, Passive smoking, Cigarette smoking, Human papillomavirus, Race, Epidemiology.