Cancer Detection and Prevention Volume 26 / Issue 2 (Mar-Apr 2002)

Table of Contents and Editor's Notes

The peer review process occasionally results in approval of controversial publications that do not necessarily reflect the viewpoint of the editors. Readers of the journal are encouraged to critically review and comment on presented data by submitting a "Letter to the Editor" that may be reprinted in a subsequent issue.

Association of a new c-Cbl related protein with the very first stages of apoptosis induction

Laurent Corsois MD , Brigitte Quatannens , Patrick Dumont , Marc Aumercierl PhD , Marie-Paule Defresne MD Daniel C.L. Regnier MD, PhD

In vivo gamma irradiation or anti-CD3 monoclonal antibodies for induction of thymic apoptosis produced rapid appearance of the apoptosis-related protein CARP90. While the expression of this nuclear protein may not be actively involved in this process it may represent a marker for the onset of apoptosis. >>>

Testosterone is a potential augmentor of antioxidant induced apoptosis in human prostate cancer cells

Kushlani Gunawardena PhD, Darrell K. Murray PhD, A. Wayne Meikle MD

The strong antioxidant pyrrolidinedithiocarbamate (PDTC) reduces nuclear factor kappaB and causes testosterone-enhanced PDTC-induced apoptosis in androgen responsive prostate cancer cell lines. >>>

Glycotherapy for cancer: remodeling of ganglioside pattern as an effective approach for cancer therapy

Hisao Nojiri, PhD , Hideaki Yamana, MD , Genzan Shirouzu, MD , Toshihide Suzuki, PhD , Hideo Isono, PhD .

Addition of erythrosin B.Brefeldin A (BFA) to the growth medium of a human colonic carcinoma cell line HCT116 increased effectiveness of the glanglioside GM3 to induce apoptosis, morphologic changes of differentiation, and arrest of cells in the G0 / G1 phase of the cell cycle. >>>

Active and passive smoking, high-risk human papilloniaviruses and cervical neoplasia

Ann L. Coker, PhD , Sharon M. Bond, CNM, MSN . Avis Williams, MSPH, Tsilya Gerasimova, PhD, Lucia Pirisi. MD

Active smoking was associated with squamous intraepithelial lesions (SIL) only among white women. Passive smoke exposure was associated with high-grade SIL (HSIL) among African American women. The results indicate that high-risk human papillomavirus (HR-HPV) may interact with active and perhaps passive exposure to increase HSIL risk. Authors suggest that HR-HPV may be necessary to cause cervical neoplasia and that smoking may serve as an important cofactor. >>>

Risk factors for lung cancer among Canadian women who 4 have never smoked

Jinfu Hu MD, Yang Mao PhD, Dagny Dryer MD, FRCPC, Kathy White BA, BEd The Canadian Cancer Registries Epidemiology Research Group

Increased lung cancer risk among never-smoker women was associated with high consumption of smoked meat and passive exposure to environmental tobacco smoke. Odds ratios (OR) with borderline significance increased with total consumption of meat, eggs or French fries and fried potatoes. Tea drinking reduced the risk of lung cancer. >>>

Cervical cancer screening among Chinese Americans

Victoria M. Taylor MD, MPHa,, J. Carey Jackson MD, MA, MPH, Shin-Ping Tu MD, MPH, Yutaka Yasui PhD, Stephen M. Schwartz PhD, Alan Kuniyuki MS, Elizabeth Acorda BA, Kathy Linc, Gregory Hislop MD, MSc

Information about cervical cancer screening behavior of Chinese American women revealed that effectiveness of cancer control interventions increased if they were multi-faceted. Educational efforts should emphasize the benefits of routine Pap smears, availability of female health providers, how to request screening tests from a physician, and the importance of physician recommendation and beliefs about the necessity of Pap smears. >>>

Effect of clinical breast examination training on practitioner's perceived competence

Ronald J. Iannotti , Lila J. Finney, Alice Anne Sander, Jessica M. De Leon

Effective clinical breast examination (CBE) training improved screening technique and reduced barriers to performing CBE. There was a significant improvement in estimating the size of the detectable lesion and trainees reported a significant decrease in the size of breast lesions that they could detect after completion of training. >>>

Prostate-specific antigen and insulin-like growth factor binding protein-3 in nipple aspirate fluid are associated with breast cancer

Edward R. Sauter, MD, PhD, Inna Chervoneva, BS, Anastasia Diamandis, BS, Javad M. Khosravi, PhD, Samuel Litwin, PhD, Eleftherios P. Diamandis, MD, PhD

Exfoliated breast epithelial cells were obtained by means of a modified breast pump. High insulin-like growth factor binding protein-3 (IGFBP-3) and low prostate-specific antigen (PSA) in nipple aspirate fluid (NAF) were associated with breast cancer. The lowest NAF PSA levels, especially in premenopausal women, and significantly high levels of NAF IGFBP-3 were noted in women with breast cancer. >>>

Detection of telomerase-positive circulating epithelial cells in ovarian cancer patients

Eva Sapi, PhD, N.I. Okpokwasili, MS, T. Rutherford, MD

Disseminated ovarian tumor cells isolated from ascites consistently expressed telomerase enzyme. CA-125 levels were significantly higher in telomerase-positive than in telomerase-negative patients. Telomerase activity was detected also in peripheral blood lymphocytes from cancer patients. This non-invasive blood test was sensitive and specific for detection of disseminated ovarian cancer cells in stage IV ovarian carcinoma patients. >>>


Herbert E. Nieburgs, MD
Worcester, MA