ISPO

P53 tumor suppressor gene in acoustic neuromas

K Monoo, MD, K Ishikawa, MD

Department of Otolaryngology, Akita University, School of Medicine, Akita, Akita Japan

Alterations of the p53 tumor suppressor gene in 21 cases with acoustic neuroma were investigated by polymerase chain reaction-restriction fragment polymorphism (PCR-RFLP) and single strand conformation polymorphism (PCR-SSCP). Neither mutation nor deletion was found. In 13 informative cases, no loss of heterozygosity (LOH) was confirmed. Thus our results further substantiate the scant contribution of p53 gene tumorigenesis and cell proliferation to acoustic neuromas.

KEY WORDS: p53 gene, acoustic neuroma, .

For more information, contact monoo@excite.co.jp

Paper presented at the International Symposium on Predictive Oncology and Intervention Strategies; Paris, France; February 9 - 12, 2002; in the section on Chromosomal Aberrations.

http://www.cancerprev.org/Journal/Issues/26/101/992/4205