Potential role of extracorporeal photochemotherapy in antineoplastic treatment

U Prati, MD,a, C Perotti, MD,d, L Roveda, MD,PhD,b, F Trotta, MD,b, P Valsecchi, MD,b, A DeRoberto, MD,b, C Rossella, MD,b, C Zonta, PhD,c, A Clerici, PhD,c, C Ferrari, PhD,c, GL Viarengo, MD,d, S Bernuzzi, MD, d, C DelFante, MD,d, L Salvaneschi, MD, d.

aChirurgia Sperimentale e Tecnologie Chirurgiche Innovative, IRCCS Policlinico San Matteo, Pavia, PV Italy bChirurgia Epatopancreatica, IRCCS Policlinico San Matteo, Pavia, PV Italy cDipartimento di Chirurgia, Universita' degli Studi di Pavia, PV Italy dServizio di Immunoematologia e Trasfusione, IRCCS Policlinico San Matteo, Pavia, PV Italy

Aim. Extracorporeal photochemotherapy (FEC) is an FDA-approved treatment for cutaneous T-cell lymphoma. It is a means of enlisting the immune-system to control malignant cells owing to its capacity to increase the immunogenicity of the surface tumour antigens. Aim of this study is to ascertain whether it is possible to extent this experience to other malignancies. Methods. We used 12 BDIX rats thus divided: Groups A and B=5 rats, they underwent hepatic metastases induction by i.v. injection of colon-carcinoma cells (1). Group C=2 rats, they were injected with saline in the spleen. After developing hepatic metastases, Group B rats underwent FEC 3 times a week for 2 weeks by i.v. injection of syngeneic rat lymphocytes irradiated with UVA in the presence of 8-methoxy-psoralen. Group C rats received 6 i.v. injections of saline. Mean and actuarial survival were calculated. Results. Mean survival: Group A=44 days (21-73); Group B=56 days (29-76), 1 rat died as a result of anesthesia and was excluded from the study, 1 rat is alive 80 days after tumour induction. Actuarial survival at 80 days after tumour induction: 0 in Group A, 25% in Group B, 100% in Group C. Conclusions. These preliminary data suggest that FEC may influence survival in cancer rats by protecting against disease progression. (1)Caignard A. et al. "Interaction between 2 cellular subpopulation of a rat colonic carcinoma when inoculated to the syngeneic host" Int J Cancer, 36:273-279,1985.

KEY WORDS: Extracorporeal photochemotherapy, Cancer vaccines, Cancer therapy.

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Paper presented at the International Symposium on Predictive Oncology and Intervention Strategies; Paris, France; February 9 - 12, 2002; in the section on Novel Therapies, Part 2.