Neuroblastoma of the urinary bladder, preclinically detected by mass screening

Seishichi Yokoyama,M.D., Hitoshi Hirakawa,M.D., Shigeru Ueno, M.D., Hiromasa Yabe,M.D.1, and Nobuyoshi Hiraoka,M.D.2

1Department of Pediatric Surgery & Pediatrics, 2Department of Pathology, Tokai University, School of Medicine, Isehara, Kanagawa, Japan, 259-1193

Since the introduction of mass screening of infants for neuroblastoma, the incidence of neuroblastoma has increased in Japan. The reason for the increased incidence is the possible inclusion of many neuroblastomas that would have regressed spontaneously and would never have been detected clinically. An extremely rare tumor at the dome of the urinary bladder in a 7-month-old infant was detected by the mass screening. Case: A 7-month-old female infant was referred because of a positive urine vanillylmanderic acid screening test. Ultrasonography showed a solid mass attached to the urinary bladder. At laparotomy a 35x30x25-mm egg-shaped tumor was found at the dome of the bladder, and a partial cystectomy was performed. Histologic diagnosis was neuroblastoma originating in the bladder wall. The patient has been free of symptoms and tumor in a follow-up period of these three years. Literature review revealed that this was the second case of neuroblastoma of the urinary bladder ever reported in the world. A review of the mass screening of neuroblastoma in Japan will be discussed.

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Paper presented at the International Symposium on Predictive Oncology and Intervention Strategies; Paris, France; February 9 - 12, 2002; in the section on Diagnostic Markers.