DNA content as a possible marker of preneoplasia in renal cysts with comparison of solid and cystic renal cancer.

J. Kovacs, E. Szabo, A. Varga a, T. Nemeth, S. Gomba, J. Kappelmayer b

Department of Pathology, Department of Urology a and Department of Clinical Biochemistry and Molecular Pathology, University of Debrecen Medical and Health Science Center, Debrecen, Hungary

Aim: Hereditary and acquired renal cysts can be complicated with malignant changes. There is evidence to suggest that development of the cysts and tumors are in some way interrelated. We wished to study the evidence of preneoplasia by determining the DNA content of the cystic epithelium and renal tumors. Methods: Surgical and autopsy tissue specimen, imprints and microdissected epithelial cell layers were applied for computer assisted DNA analyzing system. Results: Most of the inherited and acquired renal cysts just like cystic renal tumors were found to be euploid. However solid tumors proved to be aneuploid with an average DNA index of 1.45. Conclusions: Renal cysts do not present DNA alterations during their benign course. Cystic renal tumors may represent a lower grade than the solid type which likely correlates to a better prognosis. Therefore presence of prognostic tumor markers in the two forms of renal cancer is planned in the future.

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Paper presented at the International Symposium on Predictive Oncology and Intervention Strategies; Paris, France; February 9 - 12, 2002; in the section on Predictive Markers.