ISPO

Facial resurfacing in xeroderma pigmentosum with chemical peeling

Donghee Kang, MD., Ducksun Ahn, MD, FRCSC

Department of Plastic and Reconstructive Surgery, Korea University Hospital, Seoul, Korea Republic

Xeroderma pigmentosum is an autosomal recessive disease characterized by sensitivity to sunlight and the early appearance of multiple cutaneous tumors. The dermatologic manifestation can be varied, but a high prevalence of skin cancers. The clinical manifestations appear early in life, after the child is first exposed to the sun. Despite the discovery of the genetically determined DNA defect in xeroderma pigmentosum, there is no cure. Until now numerous treatment modalities have been reported, prophylaxis by avoidance of solar exposure, topical 5-fluorouracil, oral retinoids, surgical excision and resurfacing with skin grafts and dermabrasion. We experienced two xeroderma pigmentosum patients who underwent multiple trichloroacetic acid chemical peels and phenol peels. Chemical peeling is a simple procedure with less associated morbidity.

KEY WORDS: Xeroderma Pigmentosum, Chemical peeling.

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Paper presented at the International Symposium on Predictive Oncology and Intervention Strategies; Paris, France; February 9 - 12, 2002; in the section on Familial and Hereditary Cancer.

http://www.cancerprev.org/Journal/Issues/26/101/1192/4385