Establishment of a new criteria for cancer risk assessment in a Brazilian cancer center

SN Silva, MD, a MJS Floria,a MIW Achatz, MD,a BM Rossi, MD PhD,a RR Brentani,b MD PhD, JCC Rocha, MDa

aDepartment of Oncogenetics, Hospital do Cancer A.C. Camargo, Sao Paulo, Brazil. bLudwig Institute for Cancer Research - Sao Paulo branch, Sao Paulo, Brazil.

Aim: To establish a criteria to estimate the risk of cancer in the Brazilian population that seeks cancer genetics assistance. Methods: Using a review of the last two year's patient files who were assisted by the Oncogenetics Department of Hospital do Cancer A. C. Camargo, Sao Paulo. The patients were classified according to their clinical status as non-symptomatic (NS), having benign associated lesions (BL) or with personal history of cancer (CA). The family history of cancer was also classified in sporadic cancer (SPO), familial cancer (FAM) or hereditary (HER). The individual risk was then determined as high or low according to a criteria that has been previously proposed by our Department. Squamous cell and Basal cell carcinoma were excluded from the analysis of risk evaluation. Results: 565 patients were included in the study. We presented as following the data collected. Patient status NS n=212 (24 SPO, 41.7% of high risk; 124 FAM, 41.9% of high risk; 64 HER, 81.2% of high risk); BL n=163 (5 SPO, 40.0% of high risk;74 FAM, 40.5% of high risk;84 HER, 72.6% of high risk); CA n=190 (18 SPO; 104 FAM;68 HER). Total=565. Conclusion: This study proposes a criteria for personal cancer risk estimation in Brazilian population, based on the presence of benign associated lesions and family history of cancer. It enables the definition of a comprehensive guideline for diagnosis, prevention and screening programs.

KEY WORDS: Risk estimation, cancer, hereditary, familial cancer, sporadic cancer.

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Paper presented at the International Symposium on Predictive Oncology and Intervention Strategies; Paris, France; February 9 - 12, 2002; in the section on Familial and Hereditary Cancer.