Cancer Detection and Prevention Volume 25 / Issue 4 (Jul-Aug 2001)

Table of Contents and Editor's Notes

The peer review process occasionally results in approval of controversial publications that do not necessarily reflect the viewpoint of the editors. Readers of the journal are encouraged to critically review and comment on presented data by submitting a "Letter to the Editor" that may be reprinted in a subsequent issue.

Awareness of Genetic Testing for Breast Cancer Risk among Women with a Family History of Breast Cancer: Effect of Women's Information Sources on Their Awareness

Hendrika Meischke, PhD, MPH, Deborah Bowen, PhD, and Alan Kuniyuki, MS

Fewer than one-third of study participants were aware of genetic testing for breast cancer risk. It appeared that the Internet Web offered the only source of information related to awareness of genetic testing for breast cancer risk. >>>

Immunoperoxidase Detection of Polycyclic Aromatic Hydrocarbon-DNA Adducts in BreastTissue Sections

Grazyna Motykiewicz, PhD, Ewa Mafusecka, MS, Jadwiga Michaiska, PhD, Ewa Kalinowska, PhD, Jan Wloch, MD, Dorota Butkiewicz, PhD, Agnieszka Mazurek, MS, Dariusz Lange, MD, Frederica P Perera, DrPH, and Regina M. SantelIa, PhD

In patients with a lifetime environmental exposure to polycyclic aromatic hydrocarbon compounds the level of DNA adducts was significantly higher in benign breast disease than in cancer patients. >>>

Integration of Peripheral Blood Biomarkers with Computed Tomography to Differentiate Benign from Malignant Pulmonary Opacities

Thomas Alola, MD, Gerold Bepler, MD, PhD, David Harpole, MD, Philip C. Goodman, MD, H. Page McAdams, MD, Jeremy J. Erasmus, MD, James E. Herndon, PhD, and Edward F Patz, Jr, MD

In patients with lung opacities, the peripheral blood biomarkers - polymorphic epithelial proteins (MUC1) and cytokeratin 19 (CK19) - had low specificity and poor positive predictive value for bronchogenic carcinoma though 22 of 22 patients with cancer had positive MUC1 values and 21 of the 22 patients has positive CK19 levels. >>>

Carcinoembryonic Antigen and CA19-9: Implications of Quantitative Marker Measurement in Tissues for Prognosis of Colorectal Cancer

Gerhard Gebauer, MD, and Wolfgang Muller-Ruchholtz, MD, PhD

No difference in overall and disease-free survival was observed between patients with elevated or normal CEA or CA19-9 concentration in cancer tissue. Elevated CEA content in adjacent histologically normal mucosa was associated with significantly shorter overall and disease-free survival. >>>

Chronic Dosing of Oltipraz in People at Increased Risk for Colorectal Cancer

Christine E. Szarka, MD, Kang-Shen Yao, PhD, Gordon R. Pfeiffer, BS, Andrew M. Baishem, BA, Samuel Litwin, PhD, Harold Frucht, MD, Eric B. Goosenberg, MD, Paul F Engstrom, MD, Margie L. Clapper, PhD, and Peter J. O'Dwyer, MD

The candidate chemopreventive drug Oltipraz was administered at 125 mg and 250 mg biweekly for 3 months to 14 individuals with increased risk for colorectal cancer. Only the 125mg/m2 decreased glutathione S-transferase from 9.6 nmol/mg to 5.9 nmol/mg in blood lymphocytes. Neither dose of Oltipraz had a significant effect on the glutathione level or DT-diaphorese activity of colon tissue. >>>

Inhibitory Effects of Thymoquinone against 20-Methyicholanthrene-Induced Fibrosarcoma Tumorigenesis

Osama A. Badary, PhD, and Ayman M. Gamal El-Din, PhD

Administration of a potential chemopreventive agent, Thymoquinone (TQ), inhibited significantly the incidence of methylcholanthrene (MC)-induced fibrosarcoma in mice. TQ produced a reduction in liquid peroxide levels and significant increases in glutathione level, and glutathione transferase and quinone reductase activities. >>>

A Comparative Study on Cytogenetic and Antineoplastic Effects Induced by Two Modified Steroidal Alkylating Agents

Athanasios Papageorgiou, PhD, Dimtrios Tsavdaridis, MD, Georgios D. Geromichalos, PhD, Charalambos Camoutsis, PhD, Evagelos Karaberis, PhD Dionysios Mourelatos, PhD, Eleni Chrysogelou, PhD, Styianos Houvartas, BSc, and Alexandros Kotsis, MD

Two newly synthesized steroidal derivatives of nitrogen mustard added to human lymphocyte cultures showed a correlation between the magnitude of sister chromatid exchange rate response and the depression in the cell proliferation rate index. Use of the compounds for treatment of mice with Lewis Lung Carcinoma produced a 31.4% inhibition of tumor growth. >>>

Interactions between the P13K and Raf Signaling Pathways Can Result in the Transformation of Hematopoietic Cells

James A. McCubrey, PhD, John T Lee, BS, Linda S. Steelman, MA, William L. Blalock, PhD, Phillip W Moye, MS, Fumin Chang, PhD, Marianne Pearce, BS, John G. Shelton, BS, Martyn K. White, PhD, Richard A. Franklin, PhD, and Steven C. Pohnert, BS

RAF/MEK pathway activation abrogated cytokine dependence for two of three murine hematopoietic cell lines. Cytokine independence in the third cell line was achieved by additional activation of PI3K/AKT. BCL-2/BCL-XL enhanced cytokine independence mediated by RAF/MEK and PI3K/AKT. Injection of cytokine independent FD delta Raf-1 cytokine dependent clones into immunocompromised mice formed tumors. In contrast, neither the cytokine-dependent delta Raf-1-infected nor the parental FDC-P1 cell line formed tumor. >>>

Expression Pattern of Hybrid Phenotype in Adult Acute Lymphoblastic Leukemia

Kazunori Nakase, MD, PhD, Kenkichi Kita, MD, PhD, Hiroshi Miw, MD, PhD, Kazuhiro Nishil, MD, PhD, Hiroshi Shiku, MD, PhD, Kaori Nasu, MD, PhD, Hiroo Dohy, MD, PhD, Tafichi Kyo, MD, PhD, Nanao Kamada, MD, PhD, and Hiroshi Tsutani, MD, PhD

Myeloid antigen expression was observed in many cases of B-ALL as well as T1 and T2-ALL. Hybrid B and T ALL only very rarely expressed myeloid antigens. Expression of myeloid antigens in ALL appeared independent of Ph chromosome or t(4;11) in this study. >>>


Herbert E. Nieburgs, MD
Worcester, MA