Cancer Detection and Prevention Volume 25 / Issue 3 (May-Jun 2001)

Table of Contents and Editor's Notes

The peer review process occasionally results in approval of controversial publications that do not necessarily reflect the viewpoint of the editors. Readers of the journal are encouraged to critically review and comment on presented data by submitting a "Letter to the Editor" that may be reprinted in a subsequent issue.

Comparative Analysis of Two-Dimensional Protein Patterns in Malignant and Normal Human Breast Tissue

Klaus F. Czerwenka, MD, Mahmood Manavi, MD, Josef Hosmann, MD, Darko Jelincic, MD, Kerstin I. D. Pischinger, MSc, Walter B. Battistutti, DVM, Mark Behnam, BA, and Ernst Kubista, MD

Four of eight 2D PAGE images selected from a stock of 34 gels were produced from human invasive breast carcinoma tissue to create a master gel. The other four images were derived from proteins of normal breast tissue. The gel protein database, employed to locate potential tumor-associated marker proteins, revealed significant differences between the total amount of protein expressed by normal and malignant tissue. >>>

Loss of Heterozygosity and Allelic Imbalance in Apocrine Adenosis of the Breast

Abdel-Ghani A Selim, MBBCh, PhD, Andy Ryan, PhD, Ghada A. El-Ayat, MBBCh, MSc, and Clive A Wells, FRCPath,

Areas of apocrine adenosis were microdissected from archival paraffin-embedded tissue. Loss of heterozygosity and allelic imbalance were identified at high frequency in 6 of 17 cases which ranged from 16.7% at 16q to 33.3% at 13q. >>>

Differential Expression of Metallopanstimulin/ S27 Ribosomal Protein in Hepatic Regeneration and Neoplasia

Daniel R. Ganger, MD, Paul D. Hamllton, Dennis J. Klos, Shriram Jakate, MD, Lawrence McChesney, MD, and J. Alberto Fernandez Pol, MD

In chronic hepatitis metallopanstimulin-1 (MPS-1) immunostaining of hepatocytes was weak, whereas in regenerating cirrhotic nodules hepatocytes stained strongly for MPS-1. In well- and poorly differentiated carcinoma, MPS-1 staining was intense. >>>

Preoperative Serum Levels of Sialyl Lewisa, Sialyl Lewisx, and Sialyl Tn Antigens as Prognostic Markers after Curative Resection for Colorectal Cancer

Tohru Nakagoe, MD, Terumitsi Sawai, MD, Takashi Tsuji, MD, Masa-aki Jibiki, MD, Atsushi Nanashima, MD, Hiroyuki Yamaguchi, MD, Toru Yasutake, MD, Noboku Kurosaki, MD, Hiroyoshi Ayabe, MD, and Kokichi Arisawa, MD

Patients with high preoperative serum levels of sialyl Lewis A (CA19-9) and carcinoembryonic antigen had shorter disease-free survival after curative surgery than those with low serum levels. >>>

Feeding Thiol-containing Compounds, Derived from Vegetables, Fails to Inhibit N-methylnitrosourea-induced Mammary Tumorigenesis

Leonard A. Cohen, PhD, Zhonglin Zhao, MD, Brian Pittman, MS, Cesar Aliaga, BS, and Ronald Lubet, PhD,

The vegetable-derived 1,2 dithiol-3-thione (DTT) and S-methymethane thiosulphate (MMTS) failed at all doses to exhibit any chemopreventive activity on N-methylnitrosourea (NMU)-induced rat mammary tumor model. DTT at 500 ppm exerted an apparent inhibitory effect through weeks 10-16 that disappeared after 18 weeks of NMU-termination. Conversely, MMTS had no discernable effect on tumor development. >>>

Risk Factors for Benign Breast Biopsies: A Nested Case-control Study in the Alberta Breast Screening Program

Christine M. Friedenreich, PhD, Heather E. Bryant, MD, PhD, Fred Alexander, MD, Judith Hugh, MD, John Danyluk, MD, and David L. Page, MD

Risk factors for 382 benign breast biopsies and 399 controls were increased among women who were current smokers and ever smokers and who had passive smoking exposure. Decreased risk was found for women who were physically active and were ever alcohol drinkers. A 37% risk reduction was associated with hormone replacement therapy for less than 4 years. >>>

Characteristic of Malignant Tumors in Young People with Particular Emphasis on Carcinomas and Sarcomas

King-Yin Lam, FRCPA

A study of malignancies in a Chinese population revealed that 78.9% of the neoplasms in children were malignant lymphoid and neuroendocrine tumors, 69% in teenagers were malignant lymphoid tumors and 80% in young adults were carcinomas and malignant lymphoid tumors. >>>

Colorectal Cancer Screening by Primary Care Physicians in Two Medical Care Organizations

Sarah Tropman Hawley, PhD, Bernard Levin, MD, and Sally W. Vernon, PhD

A survey of 204 primary care physicians (PCPs)with a 56% response rate revealed that 82% of physicians reported recommending and/or performing or ordering a fecal occult blood test and 87% of responders indicated screening by use of flexible sigmoidoscopy (FS). Less than one-third of physicians reported using either colonoscopy or double-contrast barium enema in screening their asymptomatic patients. However, the majority of PCPs reported recommending colonoscopy in a followup for an abnormal FS finding. >>>

Allelotype of the Adenoma-Carcinoma Sequence of the Stomach

Hee Sung Kim, Dong Kyun Woo, Soo In Bae, Yong Il Kim, Woo Ho Kim

A significant difference was noted between the loss of heterozygosity on 12q, 2p and 18p in adenomas and 8q, 2p, 18p and 17p in carcinomas, suggesting that the p53 gene on 17p may be involved in gastric adenoma-carcinoma sequence. >>>

Plasma Micronutrient Antioxidants in Cancer Patients

Clifford D. Abiaka, PhD, Farida M. Al-Awadi, PhD, Hilal Al-Sayer, MC, FRCS, Sima Gulshan, PhD, Abdulla Behbehani, PhD, FRCS, and Medhat Farghaly, MC, FRCS

The distribution of carcinomas in relation to values of micronutrient antioxidants were determined in a population of 71 Kuwaitis, 45 other Arabs and 26 Indians. Kuwaiti patients had an exclusive occurrence of pancreatic cancer and a high incidence of breast, colon and thyroid cancers with high values of alpha tocopherol and low levels of antioxidants. All malignant tumors had low levels of retinol, alpha tocopherol and Toc/chol, except for the higher values in renal carcinomas. Lycopene and carotene levels were high in all tumors except for low lycopene values in in carcinomas of the pancreas, stomach, colon and kidney. >>>

Alterations of the FHIT Gene in Breast Cancer: Association with Tumor Progression and Patient Survival

Sigurdur Ingvarsson, DrMedSc, Bjarnveig I. Sigbjornsdottir, BSc, Chen Huiping, MD, Jon G. Jonasson, MD, and Bjarni A. Agnarsson, MD

Loss of heterozygosity at the fragile histidine triad (FHIT) gene was associated with estrogen- and progesterone-negative breast tumors, high S-phase fraction and 60% increased relative risk of dying. >>>


Herbert E. Nieburgs, MD
Worcester, MA