Cancer Detection and Prevention Volume 25 / Issue 1 (Jan-Feb 2001)

Table of Contents and Editor's Notes

The peer review process occasionally results in approval of controversial publications that do not necessarily reflect the viewpoint of the editors. Readers of the journal are encouraged to critically review and comment on presented data by submitting a "Letter to the Editor" that may be reprinted in a subsequent issue.

HER-2/neu Oncogene Expression in Advanced Breast Cancer

Leena A. Krogerus, MD, and Marja Leivonen, MD

The 5-year survival of patients with HER-2/neu positive grade 1 primary breast cancer was 80% and that of those with HER-2/neu negative grade 1 cancer was 36%. >>>

Thymidine Kinase 1 Immunoassay: A Potential Marker for Breast Cancer

Fan Zhang, MD, Hui Li MD, Amanda B. Pendleton, BS, Jacob G. Robison BS, Kirk 0. Monson, BS, Byron K. Murray PhD, and Kim L. O’Neill PhD

A monoclonal antibody (mAb) to thymidine kinase 1 (TK1) was tested on tamoxifen (TAM) – treated MCF-7 breast cancer cells and on serum from postoperative breast cancer patients. TK1 levels in TAM-treated cells decreased over a 10-day exposure period as determined by radioimmunoassay. The level of TK1 in the primary breast tumor correlated directly with tumor recurrence. >>>

Tumor Biology and Prognosis in Black Breast Cancer Patients—A Review

David P Rose, MD, PhD, and Renee Royak-Schaler, PhD

Breast cancer in American black women occurs at a younger age, is often estrogen receptor-negative, and has frequently more aggressive biological behavior, a high tumor cell proliferation rate, and altered p53 expression as compared to breast cancer in American white women. >>>

Sexually Transmitted Infections and Cervicovaginal Dysplasia in a Cohort of Human Immunodeficiency Virus—Positive Women in Turin

Agostino Pugliese, MD, Andrea Saini MD, Lucia Andronico, MD, Gloria Pagliano, BS, and Gloria Gallo, MD

A cohort of 135 women had human immunodeficiency virus type 1(HIV-1) infection. In about 10% of the patients a high-grade cervical dysplastic alteration was associated with HPV infection. In 4.4% of the women herpes simplex virus type 2 infection was present. >>>

Quality Assessment of Cervical Screening: A Population-Based Case-Control Study in the Côte-D’or Region, France

Gilles Chaplain, MD,, Catherine Quantin, MD Patrick Brunet-Lecomte, MD, Claude Mottot, MD,, Dominique Michiels-Marzais, MD and Annie J. Sasco, MD

The percentage of appropriate screening outside a planned program for prevention of cervical carcinoma in situ (CIS) was 41.4% compared to 67.8% by organized screening. It is suggested that a protective advantage for CIS exist even in an environment without a well-organized screening program. >>>

Parameters of Differentiation and Proliferation in Adult Granulosa Cell Tumors of the Ovary

Brigitte E. Miller, MD, Beth A. Barron, MD, Michael E. Dockter, PhD, James E. Delmore, Elvio G. Silva, MD, and David M. Gershenson, MD

Nuclear atypia was significantly more frequent (50%) in recurrent tumors (REC) than in non-recurrent (NED) tumors (13%). The mean mitotic count per 10 high-power fields was significantly increased to 5.2 in the REC group as compared to 1.7 in the NED group. >>>

Detection of APC and k-ras Mutations in the Serum of Patients with Colorectal Cancer

H. Lauschke, MD, R. Caspari, MD, W. Friedl, MD, B. Schwarz, MD, M. Mathiak, MD, P. Propping, MD, and A. Hirner, MD

K-ras mutations were present in 73% of patients with colorectal cancer but only in 27% of serum samples. The mutation cluster region (MCR) of the adenomatous polyposis coli (APC) gene was detected in 43% of tumors, but was traced to 85% of corresponding serum samples. >>>

Metallothionein Isoform 1 and 2 Gene Expression in the Human Bladder: Evidence for Upregulation of MT-1X mRNA in Bladder Cancer

Seema Somji PhD, Mary Ann Sens, MD, PhD, Donald L. Lamm, MD, Scott H. Garrett, PhD, and Donald A. Sens, PhD

The metallothionein isoform 1 and 2 (MT-1/2) gene was overexpressed in all samples of carcinoma in situ, in high-grade bladder cancer and with variable overexpression in low-grade bladder cancer and dysplastic lesions. Absence of immunohistochemical MT-1/2 staining predicted response to neoadjuvant cisplatin, methotrexate and vinblastine chemotherapy. >>>

The Possible Implication of Arginase and Diamine Oxidase in Prostatic Carcinoma

Aytac Keskinege, MD, Serenay Elgun, MD, and Erdal Yilmaz, MD

Diamine oxidase (DAO) and arginase activities were elevated approximately fivefold in cancer tissues as compared to benign prostatic hyperplasia (BPH). Gleason grades of prostatic carcinomas correlated with both arginase and DAO activities. >>>

Irradiation-Induced Effects on Mast Cells, Neuropeptides, and Atrial Natriuretic Peptide in the Rat Heart and Lung: Bases for Further Studies

K Sture Forsgren, MD, PhD, Alexander G.U. Gavén, MD, Magnus C.S. Hansson, MD, PhD, Fredrik H. Larsson, MB, Uno K.A. Kjörell DDS, Roger G. Henriksson, MD, PhD, and Lars I. Franzén, MD, PhD

The number of mast cells was much reduced both in the lung and heart of rats in response to thoracic irradiation as compared to controls. The pattern of neuropeptide expression in the lung and heart of irradiated rats was similar to that seen in controls. >>>

Assessment of the Cytatoxic and Clastogenic Activities of the Sesquiterpene Lactone Lychnopholide in Mammalian Cells In Vitro and In Vivo

Renata Canalle, Regislaine V. Burim, Joao L. Callegari Lopes, and Catarina S. Takahashi

Lychnopholide (LNP), a sesquiterpene lactone with antitumor, trypanocidal, and anitmicrobial activities was isolated from Vanillosmopsis erythropappa. No differences were found in the mitotic index as a result of treatment with dimethyl sulfoxide, LNP and doxorubicin during the G2 phase of the cell cycle. Continuous treatment of LNP exceeding 0.4 ìg/ml inhibited cell growth. >>>

Biodegradation of the Antineoplastics Vindesine, Vincristine, and Vinblastine and Their Toxicity Against Bacteria in the Aquatic Environment

Ali Al-Ahmad, Dr. rer nat, Klaus Kûmmerer, Dr. rer. nat

Antineoplastic compounds are often poorly metabolized by patients on chemotherapy. Therefore, not readily biodegradable vinca alkaloids may pass the sewage treatment and end up in surface and drinking water. >>>


Herbert E. Nieburgs, MD
Worcester, MA