Published in Cancer Detection and Prevention 2000; 24(6):610-619.

Iontophoresis Treatment of Basal Cell Carcinoma with Cisplatin: A Case Report

Thierry R.H. Bacro, PhD,a Ervin B. Holladay PhD,b McLaine J. Stith, MD,c John C. Maize, MD,c and Gory M. Smith, MSb

aDepartment of Rehabilitation Sciences, College of Health Professions, bDepartment of Clinical Services, College of Health Professions, and cDepartment of Dermatology, College of Medicine, Medical University of South Carolina, Charleston, SC

Address all correspondence to: Thierry Bacro, PhD, MS, PT, Medical University of South Carolina, Department of Rehabilitation Sciences 77 President St., P0 Box 250700, Charleston, SC 29425.

ABSTRACT: Iontophoresis is a process that uses electrical current to increase the flux of ionized substances through tissue. Iontophoresis has been used in rehabilitation to decrease inflammation and pain using dexamethasone and lidocaine. In 1993, Chang et al. reported visual improvements in the lesions of nine patients diagnosed with basal cell carcinoma (BCC) following iontophoresis of cisplatin. The present case report describes the successful treatment of a 67-year-old male with a histologically confirmed BCC on his upper anterolateral left leg. The treatment consisted of four cycles of five successive days of cisplatin iontophoresis, with a 2-week rest period between cycles. The cisplatin solution (5 mL at 1 mg/mL) was used in combination with epinepbrine hydrochloride. The effectiveness of the treatment was confirmed by post-treatment biopsies, which revealed granulation tissue scarring without evidence of BCC. Measurements of cellular proliferation were monitored immunohistochemically with Ki67 and cell cycle distribution analyzed by flow cytometry.

KEY WORDS: basal cell carcinoma, iontophoresis, cisplatin.