ISPO

Published in Cancer Detection and Prevention 2000; 24(6):564-571.

Ethnic Differences in Serum Pepsinogen Levels Among Japanese and Non-Japanese Brazilian Gastric Cancer Patients and Controls

Michael T Fahey MPH,a Gerson S. Hamada, MD,b Ines N. Nishimoto, BSc,c Luiz P. Kowalski, MD,d Kiyoshi Iriya, MD,e Joaquim J. Gama-Rodrigues, MD,f and Shoichiro Tsugane, MDa

aEpidemiology and Biostatistics Division, National Cancer Center Research Institute East, Japan; bDeparment of Preventive Medicine, Federal University of São Paulo, Paulista School of Medicine, São Paulo, Brazil; cDepartment of Epidemiology and Biostatistics, A.C. Camargo Hospital, São Paulo, Brazil; dDepartment of Head and Neck Surgery, A.C. Camargo Hospital, São Paulo, Brazil; eDepartment of Pathology, School of Medicine, University of São Paulo, São Paulo, Brazil; fDepartment of Gastroenterology, School of Medicine, University of São Paulo, São Paulo, Brazil

Address all correspondence to: Shoichiro Isugane, MD, Epidemiology and Biostatistics Division, National Cancer Center, Research Institute East, 6-5-I Kashiwanoha, Kashiwashi, Chiba-ken, 277-8577, Japan.

ABSTRACT: A low level of serum pepsinogen I (Pg I) is a risk factor for gastric cancer (GC); low levels of Pg I and the pepsinogen ratio (Pg I:Pg II) are correlated with chronic atrophic gastritis. We report serum Pg levels and compare the degree of association with GC among Japanese and non-Japanese Brazilians. Sera were cross-sectionally ascertained from 93 Japanese Brazilian patients category matched by age and sex with 110 controls, and 228 non-Japanese Brazilian patients individually matched by age and sex with one control. Among non-Japanese Brazilians, GC was associated with a Pg I level <30 ng/ml (odds ratio [OR], 2.5; 95% confidence interval [CI], 1.7-3.8) and a Pg I:Pg II ratio <3.0 (OR, 3.4; 95% CI, 2.2-5.3). However, among Japanese Brazilians, the association was present with a level of Pg I <30 ng/ml (OR, 3.5; 95% CI, 1.9-6.3), and was weak with a Pg I:Pg II ratio <3.0 (OR, 1.3; 95% CI, 0.73-2.4). Serum Pg 1 may be preferred to the Pg I:Pg II ratio to study the association between Pg and GC among Japanese Brazilians.

KEY WORDS: pepsinogen, stomach neoplasms, Brazil, ethnicity, Japan, serology.

http://www.cancerprev.org/Journal/Issues/24/6/3092