Cancer Detection and Prevention Volume 24 / Issue 6 (Nov-Dec 2000)

Table of Contents and Editor's Notes

The peer review process occasionally results in approval of controversial publications that do not necessarily reflect the viewpoint of the editors. Readers of the journal are encouraged to critically review and comment on presented data by submitting a "Letter to the Editor" that may be reprinted in a subsequent issue.

Collecting Cancer Risk Factor Data from Hospital Outpatients: Use of Touch-Screen Computers

Geneviève Y Baratiny, BSc [Hons], Elizabeth M. Campbell, PhD, Rob W Sanson-Fisher, PhD, June Graham, MHA, and Jill Cockburn, PhD

Computerized assessment of risk and desire for assistance of risk reduction revealed that 25% of smokers wanted help to quit, 48% of overweight individuals desired assistance, 75% requested referral for a Pap test and 83% for a mammogram. Desire to reduce alcohol consumption was expressed by only 2% of those at risk. >>>

New Evidence for Antioxidant Properties of Vitamin C

Aristo Vojdani, PhD, MT Mohsen Bazargan, PhD, Elroy Vojdani, and Jonathan Wright, MD

Antioxidant effects of ascorbic acid were evident from reduced DNA adduct formation and a significant increase in NK cell activity. Reduction of apoptosis was accompanied by a shift of cells from S and G2M phases to GO/Gi phase. >>>

Thyroperoxidase: A Tumor Marker for Post-therapeutic Follow-Up of Differentiated Thyroid Carcinomas? Results of a Time Course Study

Wolf G. Franke, Prof Dr Med, Klaus Zöphel, MD, Gerd R. Wunderlich, Dr Her Mat, Anneliese Kühne, MD, C. Schimming, MD, Joachim Kropp, MD, and Jan Bredow, MD

Following thyroidectomy, serum thyroperoxidase (TPO) and serum human thyroglobulin (hTg) increased immediately after radioiodine therapy followed by a decrease approximately 3 days later. It is suggested that TPO represents an indicator of cell destruction in differentiated thyroid carcinoma. >>>

Quantitative Detection of Tumor M2-Pyruvate Kinase in Plasma of Patients with Lung Cancer in Comparison to Other Lung Diseases

Joachim Schneider, MD, Harald Morr PhD, Hans-Georg Velcovsky, PhD, Günter Weisse, PhD, and Erich Eigenbrodt, PhD

A statistically significant difference in tumor M2-pyruvate kinase (tumor M2-PK) concentration in ethylenediamine tetracetic acid-plasma was seen in patients with lung cancer as compared to controls. Patients with severe acute inflammatory lung disease could not be distinguished from tumor patients. >>>

Expression of bcl-2, bax, bcl-xL, and bcl-xS in Endometrial and Cervical Tissues

S. Mozzetti, MSc, G. Ferrandina, MD, M. Marone, PhD, F. D’IngiuIIo, BSc, E. Fruscella, MD, A. De Pas qua, MD, S. Mancuso, MD, and G. Scambia, MD

Protein expression of Bcl-x, levels were significantly higher in endometrial cancer tissue than in normal postmenopausal samples, whereas no significant difference was observed between normal and neoplastic cervical tissue. Cervical carcinomas expressed significantly lower levels of bcl-2 than normal cervical epithelium. >>>

Blood Polyamine Levels After Oral Ornithine Load, Diagnostic Marker of Hyperproliferative Premalignant and Malignant Stages in a Model of Colon Carcinogenesis

René Schleiffer, PhD, Benoit Duranton, PhD, Francine Gossé, MS, Michel Hasselmann, MD, and Francis Raul, PhD

In non-fasting l,2-dimethylhydrazine (DMH)-treated rats a single dose of omithine caused a 100-fold rise in blood putrecine (PUT) levels after lShr. Premalignant states were indicated by 15- and 50-fold increases in blood PUT levels at 7 and 10 weeks after DMH treatment. >>>

Breast Cancer Screening Among Cambodian American Women

Shin-Ping Tu, MD, MPH, Yutaka Yasui, PhD, Alan Kuniyuki, MS, Beti Thompson, PhD, Stephen M. Schwartz, PhD, J. Carey Jackson, MD, MPH, and Vicky M. Taylor, MD, MPH

Women of lower socioeconomic status who lived in subsidized housing were more likely to obtain recent screening than women residing in rental property. Women who believed that cancer is curable were more likely to have a recent clinical breast examination and women who did not believe that coin rubbing is the best treatment for some diseases were more likely ever to have had a mammogram. >>>

Ethnic Differences in Serum Pepsinogen Levels Among Japanese and Non-Japanese Brazilian Gastric Cancer Patients and Controls

Michael T Fahey MPH, Gerson S. Hamada, MD, Ines N. Nishimoto, BSc, Luiz P. Kowalski, MD, Kiyoshi Iriya, MD, Joaquim J. Gama-Rodrigues, MD, and Shoichiro Tsugane, MD

Univariate median pepsinogen 1 (Pg 1) and pepsinogen II (PgII) levels were lower in Brazilian male patients than controls. Differentiated cancer was more common in male than female Japanese Brazilians. In nonJapanese Brazilians, median PgII levels were also higher for differentiated than undifferentiated cancers. >>>

Immunohistochemical Localization of Pancreatic Secretory Trypsin Inhibitor in Malignant Pancreatic Endocrine Tumors

Terumi Kamisawa, MD, Yuyang Tu, MD, Naoto Egawa, MD,a Jun -ichi Ishiwata, MD, kouji Tsuruta, MD, Atsutake Okamoto, MD, Yukiko Hayashi, MT, and Mono Koike, MD

Cells immunoreactive for pancreatic secretory trypsin inhibitor that is not expressed in normal endocrine islet cells, were identified in 9 of 28 pancreatic tumors. >>>

Detection of Prostate-Specific Membrane Antigen Expressing Cells in Blood Obtained from Renal Cancer Patients: A Potential Biomarker of Vascular Invasion

Alexandre de Ia Thille, MD, Yichen Cao, Ihor S. Sawczuk, MD, Thnji Nozemu, MD, Vivette d’Agati, MD, James M. McKiernan, MD, Emilia Bagiella, PhD, Ralph Buttyan, PhD, Martin Burchardt, MD, Carl A. Qisson, MD, Neil Bander, MD, and Aaron E. Katz, MD

Using the reverse transcriptase polymerase chain reaction (rt-PCR) assay all extracted RNAs from primary renal tumor tissue were positive for expression of prostate-specific membrane antigen (PSMA). In the peripheral blood 22% of specimens from patients with renal cancers were positive for PSMA expression. >>>

Cancer Screening Behaviors Among Korean-American Women

Hee-Soon Juon, PhD, Yoonjoung Choi, MPH, and Miyong T. Kim, PhD

Face-to-face interviews revealed that acculturation status measured by length of stay in US and English language proficiency was strongly associated with cancer screening behavior. Women who were both married and unemployed were less likely to have a pap smear than women who were both married and employed. Acculturation status was also associated with having had a mammogram and routine check-up. >>>

Fine Needle Aspiration of Bone Tumors

Sanjeev Agarwal, MS, DNB, MNAMS, FRCS, Tulika Agarwal, MD, Rajiv Agarwal, MS, MCh, Padam K. Agarwal, MD, and U.K. Jain, MS

Morphologic typing of fine needle aspiration cytology (FNAC ) aided by immunocytochemistry was possible in the majority of Ewing sarcoma, fibrosarcoma, chondrosarcoma, plasmacytoma, osteosarcoma and in all cases of lymphoma and chordoma. The overall sensitivity of FNAC was 86% and specificity was 94.7%. There were 29 false-negative and 1 false-positive diagnoses. >>>

Iontophoresis Treatment of Basal Cell Carcinoma with Cisplatin: A Case Report

Thierry R.H. Bacro, PhD, Ervin B. Holladay PhD, McLaine J. Stith, MD, John C. Maize, MD, and Gory M. Smith, MS

This case report describes the application iontophoresis to enhance penetration of skin by cisplatin. A superficial basal cell carcinoma of a 67-year-old male was treated with cisplatin iontophoresis in combination with epinephrine hydrochloride to induce local vasoconstriction and decrease the clearance rate of cisplatin from the region. The effectiveness of ionotrophic cisplatin administration for treatment of BCC is described. >>>

Deletion Mapping on the Short Arm of Chromosome 1 in Merkel Cell Carcinoma

J. Helen Leonard, PhD, Anthony L. Cook, BSc, Derek Nancarrow, PhD, Nicholas Hayward, PhD, Mireille Van Gele, BSc, Nadine Van Roy, PhD, and Frank Speleman, PhD

In an extensive study of allelic imbalance of chromosome I markers in Merkel cell carcinoma (MCC), 22 tumor biopsies and 6 cell lines were examined by PCR amplification for loss of heterozygosity (LOH). LOH or allelic imbalance of the short arm of chromosome I occurred in 75% of MCC. Seven samples demontrated more than one region of loss and the findings suggest that more than one tumor suppressor gene may be involved in the development of this tumor type. >>>


Herbert E. Nieburgs, MD
Worcester, MA