Cancer Detection and Prevention Volume 24 / Issue 3 (May-Jun 2000)

Table of Contents and Editor's Notes

The peer review process occasionally results in approval of controversial publications that do not necessarily reflect the viewpoint of the editors. Readers of the journal are encouraged to critically review and comment on presented data by submitting a "Letter to the Editor" that may be reprinted in a subsequent issue.

Insulin-like Growth Factor-1 and Breast Cancer Risk in Postmenopausal African-American Women

Tanya Agurs-Collins, PhD Lucile L. Adams-Campbell, PhD, Kyung Sook Kim, PhD, and Kevin J. Cullen, MD

The estimated relative risk for breast cancer increased by 12% for each 10 ng/ml of insulinlike growth factor-1 concentrations. No significant associations for breast cancer risk were observed for estradiol, sex hormone-binding globulin and body mass index. >>>

Phospholipid Distribution in Murine Mammary Adenocarcinomas Induced by Activated neu Oncogene

Elena Monteggia, Irma Colombo, PhD, Anna Guerra, and Bruno Berra

Neoplastic transformation induced by activated neu Oncogene expression in murine mammary tissue of transgenic mice produced a statistically significant increase of the total phospholipid content. Compared with normal mammary tissues, a significant increase occurred in the content of phophatidylethanolamine, phosphatidylcholine, and sphingomyelin. >>>

A Real-Time One-Step Reverse Transcriptase - Polymerase Chain Reaction Method to Quantify c-erbB-2 Expression in Human Breast Cancer

Valerie Pawlowski, Françoise Révillion, PhD, Louis Hornez, and Jean-Philippe Peyrat, PhD, DrSc

In 100 breast cancer specimens, use of a one-step real-time reverse transcriptase-polymerase chain reaction (RT-PCR) for c-erbB-2 gene expression was more efficient than the two-step real-time RT-PCR approach. >>>

Nuclear Grading in Invasive Ductal Breast Carcinomas

Alexandra Kalogeraki, Dimitrios Thmiolakis, Vassiliki Kozoni Maria Tzardi, John Panayiotides, John Melissas, Odysseas Zoras, Dimitrios Tsiftsis, and George S. Delides

In 120 fine-needle aspirations from invasive ductal carcinomas, nuclear grading (NG) of the cytologic specimens correlated with NG of the surgical biopsies in 93.33% of the cases. >>>

Lymphadenopathy in Children and Adolescents: Role of Fine-Needle Aspiration in Management

T Brent Ponder, MD, Debora Smith, CT , and Ibrahim Ramzy, MD

Fine-needle aspiration biopsies of palpable peripheral lymphodenopathies in 103 pediatric and adolescent patients yielded satisfactory material in 101 cases. Eighty-eight (83.0%) were diagnosed as being benign and 5 (4.7%) were positive for malignancy, including two cases of metastatic papillary carcinoma of the thyroid, two cases of Hodgkin’s disease, and one case of high grade non-Hodgkins’ lymphoma. No false-positive or false-negative diagnoses occurred. >>>

Interleukin 18 Induces a Synergistic Enhancement of Interferon Gamma Production in Mixed Murine Spleen Cell-Tumor Cell Cultures: Role of Endogenous Interleukin 12

Mark J. Micallef, PhD, Thdao Tanimoto, PhD, Keizo Kohno, PhD, Hakuo Ikegami, PhD, and Masashi Kurimoto, PhD

In spleen and tumor cell cocultures, the spleen cells that were primed with interleukin-18 (IL-18) prior to culture produced high levels of interferon gamma as a result of synergistic interaction between exogenous IL-18 and endogenous interleukin-12. >>>

Effect of Bioactive Aldehydes on Cell Proliferation and c-Myc Expression in HL-60 Human Leukemic Cells

Giuseppina Barrera, PhD, Stefania Pizzimenti PhD, Anna Serra, MD, Vito M. Fazio, Rosa A. Canuto, and Mario U. Dianzani

C-myc expression and growth of K562 and HL-60 human leukemic cells was reduced solely by 4-hydroxyundecenal (HUE). After treatments with 10 ?M of aldehydes, the hydroxyalkenals 4-hydroxynonenal (HNE), 4-hydroxyoctenal or HUE, significantly inhibited cell growth. >>>

Immunohistochemical Expression of Glutathione Transferase-pi in Untreated Primary Non-Small-Cell Lung Cancer

Tadashi Arai, Yo Yasuda, Thdatake Thkaya, kazuyoshi Hayakawa, Satoshi Toshima, Chiken Shibuya, Yoshitomo Kashiki, Naoki Yoshimi, and Maroki Shibayama

In patients with non-small-cell lung cancer, a negative immunohistochemical expression of gluatathione S-transferase-pi (GST-pi) was associated with a 66.7% response rate to chemotherapy with cisplatin plus etoposide. In patients with a positive GST-pi expression, the response rate was 26%. >>>

Human Herpesvirus 8 and Associated Diseases in a Group of 67 Human Immunodeficiency Virus-Seropositive Individuals

Agostino Pugllese, Andrea Saini, Luisa Gennero, Giorgio Marietti, Giancarlo Orofino, and Donato Torre,

In HIV+ patients, coinfection with human herpresvirus 8 (HHV-8) was associated with unfavorable progression of HIV infection and development of AIDS related neoplastic diseases. Coinfection with HHV-8 also affected CD8+ T cells and iron metabolism in addition to affecting B lymphocytes and CD4+ T lymphocytes. >>>

Induced Apoptosis and Necrosis by 2-Methylfuranonaphthoquinone in Human Cervical Cancer HeLa Cells

Jiehong Pan, Eriko Simamura, Junko Koyama, Hiroki Shimada, and Kel-Ichi Hirala

In cultured human cervical cancer HeLa cells, treatment with 2-methylnaphtho[2,3-b]furan-4,9-dione(FNQ3) induced apoptosis at the dose of 1.25 mg/mL for 24 hours, and necrosis at 5 mg/mL. Immunohistochemical staining of normal cells, treated with 10 µ/mL of FNQ3 did not reveal apoptosis >>>

Determination of p53-Mediated Transactivational Ability in Radiation-Treated Cervical Cancer

Atsutoshi Oka, MD, Yoko Harima, MD, Keizo Harima, MD, Valentina V Ostapenko, MD, Yoshimasa Tanaka, MD, Takeo Ohnishi, PhD, and Satoshi Sawada, MD

Radiation treated patients with wild type p53 expression had in 89.5% of 38 cases advanced and recurrent cervical cancer. In patients with human papillomavirus (HPV) negative tumors, a high pretreatment level of the WAF1 gene was associated with a poor radiation response. Cases with a low pretreatment level of the gene had a complete response. The radiation response in patients with HPV positive tumors was not significantly different from the HPV negative group. >>>

Inpatient Hospital Admission Through an Emergency Department in Relation to Stage at Diagnosis of Colorectal Cancer

Anthony P Polednak, PhD

First inpatient hospital admission through an emergency department of 20% of patients with colorectal cancer was a statistically significant risk factor for diagnosis of late stage disease. >>>

Measurement of Carcinoembryonic Antigen in Colonic Effluent As a High-Risk Marker for Colorectal Carcinoma

Noriya Uedo, MD, Hideki Ishikawa, MD, Hiroyuki Narahara, MD, Ikuko Akedo, MD, Kazushige Iseki, MD, Itaru Kaji, MD, Shingo Ishiguro, MD, Takaichiro Suzuki, MD, and Toru Otani, MD

Oral colorectal lavage with isotonic magnesium citrate was carried out for collection of colonic effluent as a sample for assessment of carcinoembryonic antigen (CEA). New colorectal tumors were noted significantly more frequently in patients with a high CEA level (100%) than in those with a low CEA level (22.24%) >>>

Nutrient Intake and Esophageal Cancer in the Caspian Littoral of Iran: A Case-Control Study

Fereydoun Siassi PhD, Zahra Pouransari MD, and Parviz Ghadirian, PhD

The mean daily intake of all nutrients except for riboflavin was significantly lower in patients with esophageal cancer (EC) than in control subjects. Comparison of individuals from high-risk regions with those from low-risk regions revealed that the mean daily nutrient intake of the cases and control households was similar, and the same for case households in high-risk and low-risk regions. The very great difference in EC incidence between the two regions indicates that other factors may play a role in the etiology of EC development. >>>


Herbert E. Nieburgs, MD
Worcester, MA