ISPO

targets for drug development

Preparation and biological activity of amino acid and peptide conjugates of antitumor 6-hydroxymethylacylful-vene

TC McMorris PhD, J Yu PhD, H Ngo MS, H Wang MS, MJ Kelner MD

G-quadruplex DNA ligands: Effects of binding selectivity and facilitation of G-quadruplex DNA formation on telomerase inhibition and cancer cell cytotoxicity

SM Kerwin PhD, JT Kern BA, P Wang-Thomas PhD

Changes in profiles of estrogenic receptors in experimental mammary tumors treated with different SERMs

A Actis PhD , C Rilo MSc , C Cocca MSc , E Rivera PhD , R Bergoc PhD

Opposed effects in treatment with different SERMs in a mouse mammary tumor model

A Actis PhD , C Rilo MSc , C Cocca MSc , E Rivera PhD , R Bergoc PhD

Tumor cell targeting and imaging using a novel peptide inhibitor of gelatinases

O Penate-Medina, T Söderlund, KJA Kairemo, SL Karonen, J Holopainen, PKJ Kinnunen, E Koivunen

Hi-Through-Put screening of anti-neoplastic therapeutics for potential adverse toxicological effects using Multicase software

EJ Matthews PhD , JF Contrera

The feeding of a mistletoe lectin (ML-1) -containing diet leads to a loss of viability of a murine non-Hodgkin lymphoma tumour

IF Pryme PhD , S Bardocz PhD , A Pusztai PhD , SWB Ewen MD , U Pfüller PhD

Actin polymerization agent Jasplakinolide induces cell cycle pertubation and enhances apoptosis induction in the cytotoxic agent resistant K562 cells

JY Rao MD, YS Jin BS

IGF-II/IGF-I receptor pathway up-regulates COX-2 mRNA expression and PGE2 synthesis in caco-2 human colon carcinoma cells

A Apicella , A Di Popolo , A Memoli , C Tuccillo , A di Palma , P Ricchi , R Zarrilli , AM Acquaviva

Detection of carcinoembryonic antigen in bladder cancer

G Feil BS , HJ Nelde , HW Wechsel MD , K Bichler MD

Therapy of mouse mammary carcinomas with doxorubicin-containing anti-erbB2-virosomes using a HER-2/neu transgenic (r-Neu-TG) mouse model

ER Waelti PhD , CD Gimmi MD

Differential inhibition by wortmannin, a phosphoinositide 3-kinase inhibitor, of the recovery of DNA damage inflicted by ionizing radiation or the topoisomerase II poison etoposide

N Giocanti MSc , C Hennequin MD PhD , M Fernet MSc , C Reis MSc , N Foray PhD , V Favaudon PhD

Inhibition of in vivo murine melanoma growth using gelatin nanoparticles

CA Farrugia PhD , MJ Groves DSc

Study on the sensitization of ha-ras overexpressed NIH/3T3 cells to 5-flurouracil

YS Tseng MS , TY Chang MS , CC Tzeng MD , HS Liu PhD

The "combi-targeting" approach: Effects of novel molecules with mixed EGFr tyrosine kinase and DNA-targeting properties

SL Matheson MSc , F Dudouit PhD , X Fu MSc , J McNamee PhD , BJ Jean-Claude PhD

Usefulness of p53 protein, Bcl-2 protein and Ki-67 as predictors of chemosensitivity and clinical response to chemotherapy

M Itaya MD , J Yoshimoto MD , K Kojima MD , S Futagawa MD

Influence of hypoxia on survival in conservative therapy of squamous-cell carcinoma of the oesophagus

D Taussky MD , V Rousson PhD , R Pescia MD

The peroxisome proliferator-activated receptor-γ is an inhibitor of ErbBs activity in human breast cancer cells

M Pignatelli BS , M Cortes-Canteli BS , C Lai PhD , A Santos PhD , A Perez-Castillo PhD

Multifactorial activities of nonsteroidal antiestrogens against leukemia

T Hayon MSc, L Atlas MSc, A Dvilansky MD, I Nathan PhD

An improved non isotopic test to screen large series of new inhibitor molecules of poly (ADP-ribose) polymerase usable in chemotherapy and radiotherapy strategies

P Decker PhD , EA Miranda PhD , G De Murcia PhD , S Muller PhD