Published in Cancer Detection and Prevention 2000; 24(1):86-90.

Renal Function and Serum Concentration of Five Tumor Markers (TATI, SCC, CYFRA 21-1,TPA, and TPS) in Patients without Evidence of Neoplasia

Gianfranco Tramonti M.D., 1 Marco Ferdeghini M.D., 2 Carlo Donadio M.D., 1 Maria Norpoth M.D., Carmela AnnichiaricoPh.D., 2 Romano Bianchi M.D., 1 Claudlo Bianchi M.D.1

1Dipartimento Di Medicina Interna, Sezione Di Nefrologia 2Dipartimento Di Oncologia, Sezione Di Medicina Nucleare Universita Di Pisa, Italy

Address all correspondence to: Prof Gianfranco Tramonti, Dipartimento di Medicina Interna - Sezione di Nefrologia, Clinica Medica¬óOspedale Santa Chiara, Via Roma 67. I-56126 PISA, Italy, Tel: + 39050 992584, Fax: + 39050993110

ABSTRACT The aim of this study was to evaluate the relationship between renal function and the blood level ofsome tumor markers that are low molecular weight proteins, that is, tumor-associated trypsin inhibitor (TATI),squamous cells carcinoma antigen (SCC), cytokeratin 19 fragments (CYFRA 2 1-1), tissue polypeptide antigen(IPA), and M3-specific epitope of tissue polypeptide antigen (TPS). In 41 adult patients without evidence of neo-plastic disease, glomerular filtration rate (GER) and the blood levels of crealinine and of the tumor markers weredetermined The decrease in GER was accompanied by an increase in serum levels of TAIl, SCC. CYFRA 21-I,and TPA. The serum level of tumor markers increased particularly when GFR fell below 40 mI/mm. On the basis ofthese results. the renal function must be taken into account for the clinical evaluation of the studied tumor markers.

KEY WORDS: glomerular filtration rate, low molecular weight proteins, renal failure, tumor markers.