Cancer Detection and Prevention Volume 23 / Issue 6 (Nov-Dec 1999)

Table of Contents and Editor's Notes

The peer review process occasionally results in approval of controversial publications that do not necessarily reflect the viewpoint of the editors. Readers of the journal are encouraged to critically review and comment on presented data by submitting a "Letter to the Editor" that may be reprinted in a subsequent issue.

Genetic Cancer Susceptibility and DNA Adducts: Studies in Smokers, Tobacco Chewers, and Coke Oven Workers

Helmut Bartsch, Ph.D., Margarita Rojas, Ph.D., Urmila Nair, Ph.D., Jagadeesan Nair, Ph.D., and Kroum Alexandrov, Ph.D.

Formation of BPDE ((+)-anti-Benzo(a)pyrene diol-epoxide)-DNA adducts in human lung and white blood cells was caused by a combination of CYPIAI and GSTMI genotypes. >>>

DNA Adducts in Normal Tissue Adjacent to Breast Cancer: A Review

Donghui Li, PhD, Weiqing Zhang, MD, Aysegul A. Sahin, MD, and Walter N. Hittelman, PhD

In 41% of 87 patients, Benzo(a)pyrene (BP)-like adducts were identified in samples of normal tissue adjacent to breast tumors. >>>

Survival Differences in Breast Cancer among Racial/Ethnic Groups: A Population-Based Study

Agnes Bayer-Chammard, M.D., Thomas H. Taylor, Ph.D., and Hoda Anton-Culver, Ph.D.

Prognostic factors for breast cancer differed among racial ethnic groups. Black and Hispanic women with breast cancer have shorter survival than non-Hispanic white women. >>>

Colon Polyp Registries and Colorectal Cancer Control

Robert Lev, M.D., and Janice Healey, O.S.A.

A 6-year follow-up of 252 patients after index polypectomy revealed new adenomatous polyps in 59% of 222 endoscoped subjects. >>>

Molecular Evidence for Derivation of Metastatic Cells from Minor Subclones of Primary Clear Renal Cell Carcinomas

Jacek Gronwald, M.D., Piotr Hadaczek, Ph.D., Stephan Störkel, M.D., Heidi Holtgreve-Grez, Pamela Rabbitts, M.D., Thomas Cremer, M.D., and Jan Lubinski, M.D.

A study of loss of heterozygosity (LOH) in primary and metastasic tumors, suggested that in some of the clear-cell renal carcinomas metastatic cells may have derived from tumor subclones of the primary tumors. >>>

Correlation Between Hepatic Tumor Index on Color Doppler Sonography and Tumor Vessels on Arteriography in Large Hepatocellular Carcinomas

Kazushi Numata, M.D., Katsuaki Tanaka, M.D., Takayoshi Kiba, M.D., Satoru Saito, M.D., Hiroyuki Kirikoshi, M.D., Katsumi Morita, M.D., Takeshi Shimamura, M.D., Hisahiko Sekihara, M.D.

The grade of tumor vessels was evaluated by color Doppler sonography distinguishing hepatocellular carcinomas with distinct tumor vessels from those without distinct vessels at 90% accuracy, 88% sensitivity, and 100% specificity. >>>

Ras and p53 Intracellular Targeting with Recombinant Single-Chain Fv (scFv) Fragments: A Novel Approach for Cancer Therapy?

Olivier Cochet, Ph.D., Nadège Gruel, B.S., Wolf-Herman Fridman, M.D., Ph.D., and Jean-Luc Teillaud, Ph.D.

In vivo insertion of a single-chain antibody (scFv) cDNA into an adenoviral vector dramatically decreased tumor growth. Authors suggest that intracallular scFvs may be an effective anti-tumor agent able to induce tumor regression or stop tumor growth in cancer patients. >>>

Selective Modulation of PhosphatidylSerifle Exposure on Subpopulations of Human Peripheral Blood Lymphocytes by a Plant Lectin, Viscum album Agglutinin (VAA)-l and its Recombinant Form (rVAA) in Vitro

Katarina Hostanska, PhD, Tibor Hajto, MD, Janos Fischer, PhD, Ulrich Mengs, PhD, Klaus Weber, PhD, Hans Lentzen, PhD, and Reinhard Sailer, MD

A glycosylated plant lectin (VAA-1) and its recombinant non-glycosylated form (rVAA) exhibited comparable effects on apoptosis of cultured human peripheral lymphocytes, differentiating apoptotic from necrotic cells by Annexin V measurements of phosphatidylserine and by light microscopy findings. Morphologic evidence of apoptosis consisted of cell shrinkage, chromatin clumping, and nuclear fragmentation in distinction from faintly stained necrotic cells with cytoplasmic vacuolization, nuclear swelling, and nuclear ghosts. >>>

Immunotherapy of Disseminated Fibrosarcoma in Mice Using IL-2-Producing Tumor Cells: Studies on its Mechanism and Specificity

Hiroko Tsukada, Hirohisa Yoshizawa, M.D., Tetsuro Takeda, Koichiro Ohno, Kentaro Ichikawa, Yoshiyuki Suzuki, Elichi Suzuki, Zhang-giu Wei, Masaaki Arakawa, and Fumitake Gejyo

In mice the intraperitoneal injection of IL-2 producing tumor cells significantly prolonged survival and reduction in peritoneal methylcholanthrene-induced fibrosarcoma and in the number of pulmonary metastases. >>>

Effects of Garlic on 7,12-Dimethylbenz[A]anthracene-induced Hamster Buccal Pouch Carcinogenesis

S. Balasenthil, M.PhiI., S. Arivazhagan, M.PhiI., C. B. Ramachandran, M.D.S., and S. Nagini, Ph.D.

Administration of aqueous garlic extract to Syrian hamsters significantly reduced the incidence of 7,12-dimethylbenzo(a) anthracine-induced buccal pouch carcinogenesis. >>>

Furanonaphthoquinone Analogs Possessing Selectivity in Antitumor Activity Compared to Normal Cells

Kel-Ichi Hiral, Ph.D., Junko Koyama, Ph.D., Jiehong Pan, Ph.D., Eriko Shimamura, M.H.e., Hiroki Shimada, Ph.D., Takao Yamori, Ph.D., Shigeo Sato, B.S.,C Kiyoshi Tagahara, Ph.D., and Takashi Tsuruo, Ph.D.

Synthetic and phytochemical natural analogs of 2-methylnapthol (2,3-b) furan-4,9 dione (FNQ3) given orally to nude mice demonstrated antitumor activity against carcinomas of lung, cervix, larynx, tongue, mammary gland, and osteosarcoma. >>>


Herbert E. Nieburgs, MD
Worcester, MA