Cancer Detection and Prevention Volume 23 / Issue 5 (Sep-Oct 1999)

Table of Contents and Editor's Notes

The peer review process occasionally results in approval of controversial publications that do not necessarily reflect the viewpoint of the editors. Readers of the journal are encouraged to critically review and comment on presented data by submitting a "Letter to the Editor" that may be reprinted in a subsequent issue.

Helicobacter pylori Infection on the Risk of Stomach Cancer and Chronic Atrophic Gastritis

Zuo-Feng Zhang, M.D, Ph.D., Robert C. Kurtz, M.D., David S. Klimstra, M.D.,d Guo-Pei Yu, M.D., M.P.H.,e Ming Sun, M.S., Susan Harlap, M.B., B.S. and James R. Marshall, Ph.D.

Helicobacter pylori was significantly associated with chronic atrophic gastritis (CAG) and gastric adenocarcinoma. However, no increased risk was found for H. pylori infection in the progression from CAG to gastric cancer. >>>

Secondary Tumors in Bone Sarcomas After Treatment with Chemotherapy

C. Ferrari, M.S., T. Bohling, M.D., M. S. Benassi, M.S., A. Ferraro, M.D., G. Gamberi, M.S., G. Bacci, M.D., A. Brach del Prever, M.D., L. Sangiorgi, M.D., P. Ragazzini, M.S., M. B. Sollazzo, M.S., A. Balladelli, B.A., and P. Picci, M.D.

Chemotherapy of 518 patients treated for osteosarcoma led to an increased number of secondary leukemias, particularly lymphoblastic leukemia during a median follow-up period of 97 months. >>>

Differential Expression of and Responsiveness to Transforming Growth Factor-β (TGF-β) Isoforms in Hormone-Dependent and Independent Lines of Mouse Mammary Tumors

Marcelo H. Viegas, M.S., Mariana Salatino, Mercedes Goin, Ph.D., Giselle Peters, M.S., Leticia Labriola, M.S., Jefferson Costa da Cunha, M.S., Claudia Lanari, Ph.D., Eduardo H. Charreau, Ph.D., and Patricia V. Elizalde, Ph.D.

Medroxyprogesterone acetate treatment of hormone-dependent (HD) mammary tumors produced an increase in proliferation rates and a significant decrease in transforming growth factor-ß2 (TGF-ß2) and -ß3 factor in mRNA levels. Progression to a hormone independent phenotype in ductal tumors was also associated with reduced TGF-ß2 and -ß3 expression in comparison to their HD counterparts. >>>

Development and Characterization of Melanoma Cell Lines Established by Fine-Needle Aspiration Biopsy: Advances in the Monitoring of Patients with Metastatic Melanoma

Adam I. Riker, M.D., Monica C. Panelli, Ph.D., Udal S. Kammula, M.D., Ena Wang, M.D., John Wunderlich, M.D., Andrea Abati, M.D., Patricia Fetsch, M. T., A.S.C.P., Steven A. Rosenberg, M.D., Ph.D., and Francesco M. Marincola, M.D.

Fine needle biopsies of melanoma permitted establishment of cell lines and provided an efficient and effective method for sequential sampling of a neoplasm and analysis of the growth and development of tumor-infiltrating lymphocyte populations. A strong correlation existed in melanoma antigen expression between fresh tumor explants and cultured cell lines. >>>

Short Communication: Role of Serial Tumor Markers in the Surveillance for Recurrence in Endometrial Cancer

Sue S. T. Lo, M.R.C.O.G., U. S. Khoo, M.R.C.Path., Danny K L. Cheng, F.R.A.C.O.G., T. Y. Ng, M.R.C.O.G., L.C. Wong, F.R.C.O.G., and Hextan Y. S. Ngan, F.R.C.O.G.

Normal post-treatment levels of CA125, CA 15.3 and CA 19.9 were not associated with tumor recurrence. In 12 patients with one or more increased post-treatment tumor markers, 7 patients developed recurrence. Six of the 7 patients has a 10-fold increase in CA 125 and one patient had elevated CA 19.9. >>>

Image Cytometric DNA Analysis and PCNA Expression in Transitional Cell Carcinoma of the Bladder

Anna G. Ioakim-Liossi, M.D., Peter J. Karakitsos, M.D., Dimitrios Pantazopoulos, M.D., Kiriaki G. Aroni, M.D., and Kalliopi A. Kyrkou, M.D.

Significant differences between superficial and invasive tumors and between recurring and non-recurring tumors were associated with different abmormal proliferation rates and DNA ploidy. >>>

Responsiveness of Human Prostate Carcinoma Bone Tumors to Interleukin-2 Therapy in a Mouse Xenograft Tumor Model

Sosa V. Kocheril, M.D., David J. Grignon, M.D., Ching Y. Wang, Ph.D., Richard L. Maughan, Ph.D., Emily J. Montecillo, B.Sc., Bharat Talati, M.Sc., Samuel Tekyi-Mensah, Ph.D., J. Edson Pontes, M.D., and Gilda G. Hillman, Ph.D.

Human metastatic PC-3 prostate carcinoma cells were heterotransplanted into the femur cavity of athymic Balb/c nude mice. Systemic administration of interleukin-2 inhibited formation of palpable tumors and prolonged mouse survival at nontoxic low doses. >>>

Correspondence to the Editor: A Case Report - Granulocyte Apheresis as a Possible New Approach in Cancer Therapy: A Pilot Study Involving Two Cases

Takafumi Tabuchi, M.D., Hideyuki Ubukata, M.D., Abby R. Saniabadi, Ph.D., and Tetsuo Soma, M.D.

In patients with elevated granulocyte to lymphocyte ratios, granulocyte apheresis markedly reduced tumor size and prolonged patient survival time possibly by reversal of immunodeficiency associated cytotoxic T-cell depletion. >>>

Modulation of 06-Methylguanine-DNA Methyltransferase-mediated 1-(4-Amino-2-Methyl-5-Pyrimidinyl)Methyl-3-(2-Chloroethyl)-3-Nitrosourea Resistance by Antisense RNA

Shou-Ping Ji and Yang-Pei Zhang

In Mer+HeLa S3 cells with high levels of O6-methylguanine-DNA methyltransferase (MGMT) drug resistance to 1-(4-amino-2-methyl-5-pyrimidinyl)-methyl-3-(2-chloroethyl)-3-nitrosourea could be significantly reversed by depleting MGMT gene expression with appropriate retroviral-mediated antisense RNA. >>>

Colon Cancer Treatment in Rural North and South Carolina

Sarah E. Tropman, Ph.D., Theresa Hatzell, M.P.H., Electra Paskett, Ph.D., Thomas Ricketts, Ph.D., M. Robert Cooper, M.D., and Tim Aldrich, Ph.D.

The majority of colon cancer patients in the rural Carolinas received the primary treatment suggested by the Physicians Data Query, but were less likely to have obtained adjuvant therapy. In both states a relatively small proportion of stage II colon cancer patients received some type of adjuvant therapy including chemotherapy. Significantly more stage III colon cancer patients received adjuvant therapy than did stage II patients in both states and time periods. >>>

A New Observation of the Carney's Triad, with Long Follow-Up Period and Additional Tumors

Lucia Scopsi, M.D., M.S., Pa ala Callini, M.D., and Giuseppe Muscolino, M.D.

This case presentation of a 24 year-old female followed for 42 years from June 1956 to February 1998 represents the longest followup period for a patient with Carney’s triad. The patient presented first with a cervical paraganglioma and was subsequently treated at various intervals until March 1995 for gastric leiomyosarcoma, fibrocystic breast disease, a pleomorphic adenoma of the parotid gland, an infiltrating metastatic ductal breast carcinoma and a pulmonary chondroma. Three years later, in February 1998, the patient was alive and well, illustrating the need for early recognition of tumors at a stage when surgery may be curative. >>>

Nonlinearity of Nuclear Enlargement in Hepatocytes Induced by the Carcinogen N’-Nitrosomorpholine in Ova

Christiane Wiemann, D.V.M., Harald Enzmann, M.D., Eckehard Löser, Ph.D., and Gerhard Schlüter, Ph.D.

Turkey eggs were treated with different doses of nitrosamine N' nitrosomorpholine. The hepatocarcinogen potential of the different doses was assessed in liver samples from the fertile eggs by dose-dependent quantities of cells with enlarged pale nuclei and prominent nucleoli. >>>


Herbert E. Nieburgs, MD
Worcester, MA