Cancer Detection and Prevention Volume 23 / Issue 3 (May-Jun 1999)

Table of Contents and Editor's Notes

The peer review process occasionally results in approval of controversial publications that do not necessarily reflect the viewpoint of the editors. Readers of the journal are encouraged to critically review and comment on presented data by submitting a "Letter to the Editor" that may be reprinted in a subsequent issue.

Dose-Response Relationship Between Amphibole Fiber Lung Burden and Mesothelioma

Klaus Rödelsperger, D. Sc., Hans-Joachim Woitowitz, M.D., Bernd Brückel, Rolf Arhelger, Hermann Pohlabein, M.SC., and Karl-Heinz Jöckel, D.Sc.

In 76% of mesothelioma cases a clear dose-response relationship was evidenced for asbestos amphibole fibers. In 53% of controls consisting mainly of lung cancer patients the main species were chrysotile fibers. >>>

Association of p53, K-ras and Proliferating Cell Nuclear Antigen with Rat Lung Lesions Following Exposure to Simulated Nuclear Fuel Particles

Veli-Matti Kosma, D.Sc.Med., P. Sakari Lang, Ph.D., M. Kristina Servomaa, Ph.D., Dariusz Leszczynski, Ph.D., and Tapio J. Rytömaa, D.Sc.Med.

In 58% of the cells in rat malignant lung tumors following long term exposure to neutron-activated uranium particles p53 protein levels were elevated. In hyperplastic lesions and benign tumors p53 levels were elevated in 24% of the cells. K-ras protein levels were elevated in less than 5% of the cells in all types of lesions. >>>

Microsatellite Instability and K-ras Mutations in Gastric adenomas, With Reference to Associated Gastric Cancers

Jun Isogaki, M.D., Kazuya Shinmura, M.D., Wang Yin, M.D., Tomio Arai, M.D., Kenji Koda, M.D., Taizo Kimura, M.D., Isamu Kino, M.D., and Haruhiko Sugimura, M.D.

Microsatellite instability was detected in 35.5% of adenomas that were associated with gastric carcinoma and in 14% of adenomas without cancer. K-ras mutations were found in 16% of flat adenomas with or without cancer >>>

The Role of Cytokines and Chemokines on Tumor Progression: A Review

Sussan K. Ardestani, Ph.D., Paula Inserra, Ph.D., David Solkoff, B.S., and Ronald R. Watson, Ph.D.

This review article evaluates the role of cytokines in the regulation of cell proliferation and tumor progression. The functions of epidermal growth factors, transforming growth factors, basic fibroblast growth factors and block of tumor growth by inhibition of receptor tyrosine kinase activity are analyzed. Also described are the inhibition of malignant cell growth by cytokines and induction of tumor progression directly by activation of the K-ras oncogene, inactivation of antioncogenes and increased angiogenesis or indirectly by immunosuppression through depressed polymorphonuclear and macrophage cell function, depressed Ig production by B cells, reduced NK cytotoxicity and more often by inability of lymphocytes to respond to mitogenic stimuli. >>>

Altered Release of Tumor Necrosis Factor and its Soluble Receptor in Non-Hodgkin’s Lymphoma Patients

Vipul B. Rathore, M.Sc., Suresh H. Advani, M.D., and Jayshree J. Nadkarni, Ph.D.

In non-Hodgkin lymphoma patients the soluble p75 tumor necrosis factor receptor release from peripheral blood mononuclear cells was increased in early stages of the disease and was severely depressed in advanced stages. >>>

Role of Estradiol Metabolism and CYP1A1 Polymorphisms in Breast Cancer Risk

Emmanuela Taioli, M.D., H. Leon Bradlow, Ph.D., Samantha V. Garbers, B.A., Daniel W. Sepkovic, Ph.D., Michael P. Osborne, Ph.D., Julie Trachman, Ph.D., Sabya Ganguly, Ph.D., and Seymour J. Garte, Ph.D.

Individuals, homozygous for the MSP-1 variant, showed a marked decrease in 2-hydroxylation of estradiol and an increased risk for breast cancers. >>>

Estrogen and Progesterone Receptor Concentrations and Prevalence of Tumor Hormonal Phenotypes in Older Breast Cancer Patients

Jacqueline Ashba, M.P.H., and Abdulmaged M. Traish, Ph.D.

Examination of tissue biopsies from 1739 breast cancer patients revealed that ER+PR+ tumor phenotype increased with age while ER-PR+ status and ER-PR- tumors decreased with age whereas ER+PR- phenotypes showed no consistent trend with age. Change of tumor phenotype ER+PR+ to ER-PR- may result from tumor cell dedifferentiation or as a manifestation of tumor progression. >>>

Classification of Breast Tumors by Grade and Steroid Receptor Status Using Pattern Recognition Analysis of Infrared Spectra

Michael Jackson, Ph.D., James R. Mansfield, M.Sc., Brion Dolenko, M.Sc., Rajmund L. Somorjai, Ph.D., Henry H. Mantsch, Ph.D., and Peter H. Watson, M.D.

Infrared spectroscopy of tissue sections from 77 breast tumors and multivariate classification methods and strategies determined the grade of human breast carcinomas and permitted classification of tumors according to hormone receptors. >>>

A Motivational Message, External Barriers, and Mammography Utilization

Diane Ruth Lauver, Ph.D., R.N., C.S., F.A.A.N., and Janet Kane, Ph.D.

Mammography screening was utilized by 64% of women without external barriers and by 26% of women with barriers. The most common barriers were distance and transportation to the clinic, high cost and lack of financial coverage for mammography. The effectiveness of clinicians motivational messages about the benefits of mammography were contingent upon external barriers. >>>

Breast Cancer Screening and Family History Among Rural Women in Wisconsin

MaryAnn T. Lippert, M.S., Elaine D. Eaker, SC.D., Robed A. Vierkant, M.A. S., and Patrick L. Remington, M.D., M. P. H.

Data from 2240 women revealed that screening mammography was utilized by 60% of women with a family history of breast cancer against 47% without a family history. Physicians recommendation had a positive effect on women compliance with utilization of screening mammography. >>>


Herbert E. Nieburgs, MD
Worcester, MA