Cancer Detection and Prevention Volume 23 / Issue 2 (Mar-Apr 1999)

Table of Contents and Editor's Notes

The peer review process occasionally results in approval of controversial publications that do not necessarily reflect the viewpoint of the editors. Readers of the journal are encouraged to critically review and comment on presented data by submitting a "Letter to the Editor" that may be reprinted in a subsequent issue.

Human Haptocorrin in Hepatocellular Carcinoma

Florian Boisson, M.S., Sophie Fremont, Ph.D., Colette Migeon, M.D., Florence Nodari, M.D., Suzanne Droesch, M.S., Philippe Gerard, M.S., R.-Michel Parache, M.D., and J.-Pierre Nicolas, M.D.

Storage of Haptocorrin (HC) is modified in hepatic carcinogenesis. In hepatocellular carcinoma HC-serum levels are elevated as a result of increased hepatic synthesis and decreased uptake by the liver. >>>

Understanding Meta-Analysis in Cancer Epidemiology: Dietary Fat and Breast Cancer

Renée A. Harrison, Ph.D., and John W. Waterbor, M.D., Dr.PH.

Meta-analyses comparing patient data (MAP) with data from the literature (MAL) was made for relative risk estimates of the relationship between dietary fat and breast cancer. >>>

Presystemic Intestinal Metabolism of N-Nitrosodimethylamine

Johannes Schulze, P.D.Dr.

Uptake of the liver carcinogen, N-Nitrosodimethylamine (NDMA), is prevented by cytochrome P-450 enzymes. In the mouse, low amounts of P-450 causes rapid uptake of NDMA through the intestinal wall. >>>

Mucosal Expression of Carcinoembryonic Antigen 19-9 in Patients with Gastritis and Gastric Cancer

Giuseppe Esposito, Ph.D., Alfonso Tempesta, M.D., Maria Giulia Galati, Ph.D., Mario de Bellis, M.D., Giovanni Battista Rossi, M.D., Maria I. Potena, B.S., Pietro Marone, M.D., Bruno Daniele, M.D., Ph.D., and Silvana Del Vecchio, M.D.

Mucosal tissue concentrations of carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 in humans increased from chronic superficial gastritis to chronic atrophic gastritis (CAG) and to gastric cancer. In intestinal metaplasia (IM) mucosal CEA levels were higher than in nonmetaplastic mucosa. Increased production of CEA by gastric cells in patients with CAG and IM is an expression of a premalignant change. >>>

Lymphovascular and Neural Invasion in Low-Lying Rectal Carcinoma

Luis Fernando Moreira, M.S., Masaichi Kenmotsu, M.D., Akira Gochi, M.D., Noriaki Tanaka, M.D., and Kunzo Orita, M.D., Ph.D.

In patients with Duke’s B and C colorectal cancer the 5-year survival rates were significantly decreased in presence of lymphovascular and neural invasion. Lymphovascular invasion is a predictor for distant metastasis and neural invasion for local recurrence. >>>

Analysis of SAS gene, CDK4 and MDM2 Proteins in Low-Grade Osteosarcoma

P. Ragazzini, M.S., G. Gamberi, M.S., M. S. Benassi, M.S., C. Orlando, M.D., R. Sestini, M.S., C. Ferrari, M.S., L. Molendini, M.S., M. R. Sollazzo, M.S., M. Merli, M.S., G. Magagnoli, M.S., F. Bertoni, M.D., T. Bohling, M.D., M. Pazzagli, M.D., P. Picci, M.D.

Low-grade osteosarcomas may be characterized by alterations of multiple genes, SAS, MDM2 and CDK4 from chromosomal segments 12q13-15. Prognostic value is attributed to increased expression of CDK4 and MDM2 protein in patients with primary tumors and lung metastasis. >>>

Neoangiogenesis and Squamous Cell Carcinoma of the Tongue

Shiva S. Forootan, M.D., Andrew S. Jones, M.D., and Timothy R. Helliwell, M.D.

By univariate analysis, low vascular vessel count adjusted for tumor area is associated with neck node metastasis. Multivariate analysis indicates that carcinomas with a low vessel count tend to have a good prognosis. >>>

p53 Overexpression and Mutation in Endometrial Carcinoma: Inverted Relation with Estrogen and Progesterone Receptor Status

Kenji Niwa, M.D., Toshiko Murase, M.D., Shigeo Morishita, M.D., Midori Hashimoto, M.D., Naoki Itoh, M.D., and Teruhiko Tamaya, M.D.

Overexpression of p53 was significantly inversely related to estrogen receptor and progesterone receptor immunoreactivities. p53 overexpression in most endometrial carcinomas may occur unrelated to estrogenic stimulation and estrogenic stimulation may not be associated with p53 inactivation. >>>

Prognostic Significance of Flow Cytometric Deoxyribonucleic Acid Analysis for Patients with Superficial Bladder Cancers: A Long-Term Follow-Up Study

Masaaki Tachibana, M.D., Ayako Miyakawa, M.D., Michiko Miyakawa, M.D., Shiro Saito, M.D., Kaoru Nakamura, M.D., Shiro Baba, M.D., and Masaru Murai, M.D.

Flow cytometric DNA ploidy analysis of human bladder cancers revealed increased survival rates for diploid tumors and those with either less than 10% S-phase cells or with a low percentage of tetraploid cells. Decreased survival was significantly associated with aneuploid tumors and with increased percentage of either S-phase or tetraploid cells. >>>

Biomarkers in Monitoring for Efficacy of Immunotherapy and Chemoprevention of Bladder Cancer with Dimethylsulfoxide

George P. Hemstreet III, M.D., Ph.D., Jian Yu Rao, M.D., Robert E. Hurst, Ph.D., Rebecca B. Bonner, M.S., John E. Mellott, B.S., and Gina M. Rooker, M.D.

G-actin levels predicted risk of recurrence by quantitative fluorescence image analysis of uroepithelial cells from bladder wash samples immediately or following intravesical bacille Calmette-Guerin or dimethylsulfoxide treatment. Biochemically altered cells were frequently also found within adjacent normal-appearing uroepithelium as a "field effect." >>>

Subcutaneous Administration of Interleukin-2 and Interferon-α2b in Advanced Renal Cell Carcinoma: Long-Term Results

Maria Cristina Locatelli, M.D., Giovanna Facendola, M.D., Giorgio Pizzocaro, M.D., Luigi Piva, M.D., Carlo Pegoraro, M.D., Enrico Bobbio Pallavicini, M.D., A. Signaroldi, M.D., M. Meregalli, M.D., Franco Lombardi, M.D., Giordano D. Beretta, M.D,, Franco Scanzi, M.D., Roberto Labianca, M.D., Giuseppe Dallavalle, M.D., and Gino Luporini, M.D.

Subcutaneous administration of combined r-interleukin-2 and r-interferon alpha for treatment of advanced renal cell carcinomas (RCC) was associated with objective responses superior to chemotherapy. Immune treatment of RCC in advanced phases, though incurable, may result in some durable remissions. >>>

Commentary: Barrett's Esophagus: Are Caucasians the Only Ethnic Group At Risk?

Ronnie Fass, M.D.


Herbert E. Nieburgs, MD
Worcester, MA