ISPO

Published in Cancer Detection and Prevention 1998; 22(6):526-532.

The Use of Soy Protein Isolate to Reduce the Severity of 13-cis Retinoic Acid-Induced Hypertriglyceridemia

John D. Radcliffe, Ph.D., Victorine L. Imrhan, Ph.D., Andie M. Hsueh, Sc.D.

Department of Nutrition and Food Sciences, Texas Woman's University, Houston, TX 77030 J.D.R. and Department of Nutrition and Food Sciences, Texas Woman's University, Denton, TX 76204 V.L.I. and A.M.H.

Address all correspondence and reprint requests to: John D. Radcliffe, Ph.D., Department of Nutrition and Food Sciences, Texas Woman's University, 1130 M. D. Anderson Boulevard, Houston, TX 77030

ABSTRACT: The ability of soy protein isolate to reduce the severity of 13-cis retinoic acid (13cRA)-induced hypertriglyceridemia was assessed in an animal model of this condition (rats fed a 13cRA-containing, casein-based diet). Male Fischer 344 rats (N=7 per group) were fed purified diets containing either casein or soy protein isolate and having no 1 3cRA or the retinoid included at a level of 100 mg/kg diet--designated as groups C, S, C + R, and S + R, respectively. Diet had no effect on either food intake or final body weight, and the serum levels of 13cRA were not significantly different for groups C + R and S + R. Groups fed diets having 13cRA had significantly (P < 0.05) higher serum triglyceride levels than ones fed the corresponding retinoid-free diets, but the serum triglyceride level for group S + R was significantly lower than for group C + R, being 2.99 vs. 6.97 mM (265 vs. 617 mg/dL). Thus, soy protein isolate can reduce the severity of 13cRA-induced hypertriglyceridemia without affecting serum retinoid level.

KEY WORDS: Retinoids, Triglycerides, Rat, Chemoprevention.

For more information, contact HF_Radcliffe@twu.edu

http://www.cancerprev.org/Journal/Issues/22/6/295