Cancer Detection and Prevention Volume 22 / Issue 6 (Nov-Dec 1998)

Table of Contents and Editor's Notes

The peer review process occasionally results in approval of controversial publications that do not necessarily reflect the viewpoint of the editors. Readers of the journal are encouraged to critically review and comment on presented data by submitting a "Letter to the Editor" that may be reprinted in a subsequent issue.

Sociodemographic Characteristics, Smoking, Medical and Family History, and Breast Cancer

Parviz Ghadirian, Ph.D.,a Andre Lacroix, M.D.,b Chantal Perret, D.E.A.,a Patrick Maisonneuve, Ph.D.,c and Peter Boyle, Ph.D.c

Ever-married women, cigarette smokers, women with a history of asthma and those who had been pregnant, had a low risk of developing breast cancer. A high risk of developing breast cancer was associated with breast problems such as fibrocystic disease, late age at first full-term pregnancy and a family history of ovarian cancer. >>>

Early and Late Stage Breast Cancer in a Managed Care Setting in Relation to Mammography Screening

Sharon J Rolnick, Ph.D., Patrick J O'Connor, M.D., Jody M. Jackson, B.A., Raymond G. Boyle, Ph.D., Nico P. Pronk, Ph.D., and Linda M Loes, M.D.

Advanced stage breast cnacer was diagnosed in women who had not had annual mammography. Increased use of mammography screening improved breast cancer detection in early stages. >>>

Immunohistochemical Expression of ABH/Lewis-Related Antigens in Primary Breast Carcinomas and Metastatic Lymph Node Lesions

Tohru Nakagoe, M.D.,a Kiyoyasu Fukushima, M.D.,b Takashi Tuji, M.D., a Terumitu Sawai, M.D., a Atushi Nanashima, M.D., a Hiroyuki Yamaguchi, M.D., a Tohru Yasutake, M.D., a Shinsuke Hara, M.D., a Hiroyoshi Ayabe, M.D., a Tatuki Matuo, M.D., c and Shimeru Kamihira, M.D. d

Expression of Lewis-related antigens was usually present in noncancerous tissues and in benign lesions, such as mastopathy and fibroadenoma. The expression rate of Lewis-related antigens in primary breast carcinoma was significantly lower than in noncancerous tissues. In carcinomas with lymphnode metastases a lower percentage of cases expressed the Lewis-related antigens than in primary carcinoma and noncancerous tissues. >>>

Apoptosis and Suppression of Tumor Growth by Artepillin C Extracted From Brazilian Propolis

Tetsuo Kimoto, M.D., Ph.D.,a Shigeyuki Arai, D.V.M., Ph.D.,a Michihiro Kohguchi, B.S., a Miho Aga, B.Pharm.,a Yutaka Nomura, B.S., a Mark J. Micallef, Ph.D.,a Masashi Kurimoto, M.S.,a and Keiichiro Mito, Ph.D.b

Artepillin C (extract from Brazilian propolis) inhibited tumor cell growth and DNA synthesis of human and mouse cancer cells. Artepillin C-induced apoptosis and massive death of cancer cells in vivo, while long-term administration produced cancer tissue necrosis, surrounded by activated macrophages, fibroblasts and lymphocytes with proliferation of collagen fibers >>>

Screening for In Vitro Anti-Tumor-Promoting Activities of Edible Plants From Indonesia

Akira Murakami, Ph.D.,a Hideaki Morita, B.S.,a Ratu Safitri, M.S.,b Aseng Ramlan, Ph.D.,b Koichi Koshimizu, Ph.D.,a and Hajime Ohigashi, Ph.D.c

Sixty-four (48%) of 135 samples of edible Indonesian plants inhibited the tumor promotor activity of Epstein-Barr virus in human B lymphoblastoid cells. The plant families Zingiberaceae and Umbeliferae were particularly active inhibitors and are therefore suggested as a desirable source of effective cancer preventive agents. >>>

The Use of Soy Protein Isolate to Reduce the Severity of 13-cis Retinoic Acid-Induced Hypertriglyceridemia

John D. Radcliffe, Ph.D., Victorine L. Imrhan, Ph.D., Andie M. Hsueh, Sc.D.

The untoward effect of 13-cis retinoic acid (B-cRA) induced hypertriglyceridemia was significantly lower in animals that were fed also soy protein-containing diets. The use of soy protein was not associated with a change in serum retinoids levels and is therefore unlikely to interfere with the clinical effectiveness of B-cRA. >>>

A Meta-Analysis of Painting Exposure and Cancer Mortality

Ruoling Chen, M.D., Ph.D., and Anthony Seaton, M.D., F.R.C.P., F.F.O.M.

The carcinogenic risk of workers exposed to paints was assessed by meta-analysis of published date on standardized mortality ratios (SMR) from 17 studies. The highest risks of cancer deaths were from leukemia and liver cancer. SMRs for cancer of the esophagus, stomach, lung and urinary bladder were also significantly raised. >>>

Delineation of Maxillofacial Cutaneous Lesions by Means of High Resolution Magnetic Resonance Imaging

J. Mäurer, M.D., F.D. Knollmann, M.D., B. Hell, M.D., C. Radke, M.D., R. Felix, M.D.

Differential diagnoses of skin tumors in the maxillofacial region were examined by high-resolution magnetic resonance imaging. Contrast enhancement and contrast to noise ratios did not permit differentiation of malignant lesions from benign tumors. Tumor growth properties could not be differentiated by contrast to noise ratio. Authors conclude that clinical examination remains the gold standard in preoperative skin tumor diagnosis. >>>

A Rapid Method for DNA Extraction from Fine-Needle Aspiration Biopsies of Thyroid Tumors, and Subsequent RET Mutation Analysis

Jan Zedenius, M.D. Ph.D., Trisha Dwight, B.S., Bruce G. Robinson, M.D., Leigh Delbridge, M.D., Martin Bäckdahl, M.D., Ph.D., Göran Wallin, M.D., Ph.D., Catharina Larsson, M.D. Ph.D., Günther Weber, Ph.D.

A method is described for RET protooncogene mutation analysis of preoperative fine-needle aspiration biopsies (FNABs) from medullary thyroid carcinoma. DNA may be extracted from FNABs in less than 20 min and does not differ in quality from DNA extracted by standard methods when used for RET mutation analysis. >>>

Prognostic Significance of Heat Shock Proteins HSP70 and HSP90 in Endometrial Carcinomas

Kanako Nanbu, M.D., Ikuo Konishi, M.D., Masaki Mandal, M.D., Hideki Kuroda, M.D., Atia A. Hamid, M.D., Takayuki Komatsu, M.D., and Takahide Mori, M.D.

Immunoreactivity specific to heat shock proteins HSP70 and HSP90 was detected in the nucleus and cytoplasm of cells from endometrial carcinoma. Patients with HSP70-positive carcinoma had a significantly lower survival rate than those with HSP70-negative tumors. In contrast, patients with strong expression of HSP90 in the tumor had a favorable outcome compared with those who had weakly HSP90-positive carcinomas. >>>


Herbert E. Nieburgs, MD
Worcester, MA