Cancer Detection and Prevention Volume 22 / Issue 3 (May-Jun 1998)

Table of Contents and Editor's Notes

The peer review process occasionally results in approval of controversial publications that do not necessarily reflect the viewpoint of the editors. Readers of the journal are encouraged to critically review and comment on presented data by submitting a "Letter to the Editor" that may be reprinted in a subsequent issue.

Mutant p53 Correlates with Reduced Expression of Thrombospondin-1, Increased Angiogenesis, and Metastatic Progression in Melanoma

Steven W. Grant, M.D., Ainura S. Kyshtoobaye Va, M.D., Ph.D. , Tom Kurosaki, M.S. , James Jakowatz, M.D. , and John P. Fruehauf, M.D., Ph.D.

Thrombospondin (TSP-1) inhibited tumor progression and metastasis. Mutant p53 expression by malignant melanoma was associated with decreased TSP-1 expression, with increased microvessel counts, and was more common in metastatic sites. >>>

Alcohol-Stimulated Promotion of Tumors in the Gastrointestinal Tract

Siraj I. Mufti, Ph.D.

Esophageal tumors were induced in 30% of male Sprague-Dawley rats by administration o N-nitrosomethylbenzylenine (NMBzA). Ethanolic Lieber-DeCarli diet produced promotion of the NMBzA induced tumors through it's ability to generate oxygen free radicals, associated with increased lipid peroxidation. >>>

Formation of Nitrosamines During Consumption of Nitrate- And Amine-Rich food,and the Influence of the Use of Mouthwashes

Jan M. S. van Maanen, Ph.D., Danielle M. F. A. Pachen, M.Eng., Jan W. Dallinga, Ph.D., and Jos C. S. Kleinjans, Ph.D.

Consumption of diet rich in nitrate and amines increased formation of carcinogenic nitrosamines. Use of an antibacterial mouthwash containing chlorhexidine inhibited nitrosamine formation when compared with use of a control mouthwash. >>>

Aspirin Use and p53 Expression in Colorectal Cancer

A. N. Freedman, Ph.D., A. M. Michalek, Ph.D., H. A. Weiss, Ph.D. , Z. F. Zhang, M.D., Ph.D., J. H. Marshall, Ph.D. , C. J. Mettlin, Ph.D.,, J. E. Asirwatham, M.D. , N. J. Petrelli, M.D., and N. E. Caporaso, M.D.

A decrease in risk of colorectal cancer was observed for regular aspirin users when compared with nonusers. No significant differences were noted in the effect of aspirin use on cancer risk between cases with and without p53 overexpression. >>>

Antitumor Effect of Medium-Chain Triglyceride and its Influence on the Self-Defense System of Body

Yasuhiko Kimoto, M.D., Yoshio Tanji, M.D., Tetsuya Taguchi, M.D., Takuji Sugimoto, M.D., Taro Watanabe, M.D., Fumine Tsukamoto, M.D., Shoshin Kim, M.D., Kohri Yoneda, M.D., Yuuki Takamura, M.D., Masaaki Izukura, M.D., Elichi Shiba, M.D., and Shin-ichiro Takai, M.D.

The proliferation of tumor cells in vitro in the presence of human plasma was suppressed by emulsified triglyceride in a dose dependent manner without affecting the shape of the normal immune system. >>>

Multiple Mechanisms of Action of the Benzamides and Nicotinamides as Sensitizers of Radiotherapy: Opportunities for Drug Design

Ronald W. Pero, Ph.D. , Anders Qisson, Ph.D. , Amir Amiri, M.D. , and David Chaplin, Ph.D.

The benzamide and nicotinamide, N-substituted analogs unduced apoptosis, inhibited cell proliferation, reactred with radiation, activated poly adenosine diphosphate ribosyl transferase (ADPRT) and minimally affected tumor blood flow. In contrast, the non-N-substituted analogs did not induce apoptosis, inhibited cell proliferation, or react with radiation, but did inhibit poly ADPRT and had a profound effect on tumor blood flow. Neither of the analogs induced necrosis. >>>

Circulating Levels in Serum of Total Sialic Acid, Lipid-Associated Sialic Acid, and Fucose in Precancerous Lesion and Cancer of the Oral Cavity

Vasanti R. Rao, Ph.D, Lakshmi Krishnamoorthy, Ph.D., S. V. Kumaraswamy, M.D.S., and Ginja Ramaswamy, Ph.D.

The mean values of total sialic acid and of lipid-associated sialic acid in sera of patients with pre-cancerous lesions and with cancer of the oral cavity were significantly elevated in comparison with controls. >>>

Oncogene and Suppressor Gene Expression as a Biomarker for Ethylene Oxide Exposure

István Ember, M.D., Ph.D. , lstván Kiss, M.D. , Gycörgy Gombkötö, M.D. , Erzsébet MüIIer, M.D., Mária Szeremi, M.D.

In hospital personnel exposed to ethylene oxide, the expression of N-ras and p53 genes in the white blood rells was higher than in non-exposed hospital control groups. >>>

Relations of Nm23 Expression to Clinicopathologic Variables and Proliferative Activity of Gastric Cancer Lesions

Takeshi Nakamura, M.D. , Yoshiki Tabuchi, M.D., Ph.D., and Masakazu Ohno, M.D.

In gastric cancer lesions with nm23 gene expression the proliferative activity of cancer cells, determined by proliferating cell nuclear antigen labeling index was significantly higher than in lesions without nm23 expression. >>>

Cyanine Fluorochrome-Labeled Antibodies in Vivo: Assessment of Tumor Imaging Using Cy3, Cy5, Cy5.5, and Cy7

Byron Ballou , Gregory W. Fisher , Jau-Shyong Deng , Thomas H. Hakala , Meera Srivastava , and Daniel L. Farkas

In tumor bearing animals, injected with four cyanine flourochrome-labeled monoclonal antibodies, all cyanine dyes, Cy3, Cy5, Cy5.5, and Cy7 labeled superficial tumors. However deeper structures through several milimeters of tissue were better visualized by Cy7. >>>

Successful Treatment of Accelerated and Blastic Phase of Chronic Myeloid Leukemia with High-Dose Interferon-α Combined with Hydroxyurea

U. Jehn, M.D., Ph.D., and V. Heinemann, M.D.

Nine patients with either acceleration of chronic myeloid leukemia or blast crisis were treated with a combination of daily subcutaneous interferon X and 3g. hydroxyurea orally for two to either months. All patients responded to therapy by reversal to the chronic phase that lasted six to seven months in five patients, without the prolonged cytopenia of intensive chemotherapy. >>>

The Outcome of Liver Transplantation At Various Times (70, 120, and 134 days) After the Initiation of Carcinogenesis in Rats

Kenji Yano, M.D., Ph.D. , Yasuhiko Fukuda , Ryo Sumimoto , Hisao Ito , Tsuneo Okumichi , and Kiyohiko Dohi

The timing of liver transplantation in relation to survival of patients with unresectable liver cancer was studied in pure-strain rats by liver transplantation at 70, 120, and 134 days after initiation of diethylnitrosamine induced hepatocellular carcinoma. Liver transplantation at 70 and 120 days after initiated carcinogenesis was assiciated with longer mean survival than in cases of liver transplantation of 134 days. >>>


Herbert E. Nieburgs, MD
Worcester, MA