Cancer Detection and Prevention Volume 22 / Issue 2 (Mar-Apr 1998)

Table of Contents and Editor's Notes

The peer review process occasionally results in approval of controversial publications that do not necessarily reflect the viewpoint of the editors. Readers of the journal are encouraged to critically review and comment on presented data by submitting a "Letter to the Editor" that may be reprinted in a subsequent issue.

Evaluation of Cell-Mediated Immunity and Circulating Immune Complexes as Prognostic Indicators in Cancer Patients

Mehar Aziz, MD, DNB, Shakeel Akhtar, MD, Abida Malik, MD

In cancer patients decreased cell-mediated immunity and increased circulating immune complexes were associated with unfavorable prognosis and subsequent clinical manifestations of an increased tumor mass. >>>

Risk Factors for Glioma in Adults: A Case-Control Study in Northeast China

Jinfu Hu, MD, Kenneth C Johnson, PhD, Yang Mao, PhD, Lihong Guo, MD, Xigong Zhao, MD, Xiuyan Jia, MD, Danzhou Bi, MD, Guirong Huang, MD, Ruizhang Liu, MD

High consumption of vegetables and fruit were associated with decreased glioma risk. Increased glioma risk was found in association with liquor consumption, occupational exposure to microwaves and head X-ray. >>>

Cigarette Smoking and Cervical Dysplasia Among Non-Hispanic Black Women

Peter A. Kanetsky, PhD, Marilie D Gammon, PhD, Jeanne Mandelblatt, MD, MPH, Zuo-Feng Zhang, MD, PhD, Evangelyn Ramsey, NP, Thomas C Wright, Jr, MD, Louys Thomas, MD, Stephen Matseoane, MD, Nomenida Lazaro, MD, Hiroko T Felton, MD, Ranjit K Sachdev, MD, Ralph M Richart, M.D, John P Curtin, MD

HIV-negative, non-Hispanic black, low-income women with high-grade cervical dysplasia were roughly four times more likely to be smokers compared to non-smoking controls. >>>

Immunohistochemical Prediction of Radiation Response and Local Control in Radiation Therapy for Cervical Cancer

Takashi Nakano, MD, Kuniyuki Oka, MD, Atsuko Ishikawa, MD, and Shinroku Morita, MD.

In cervical cancer patients treated with radiation the five-year survival was significantly better with a Ki-67 growth fraction index above 33% than below 33%. C-erbB-2 oncoprotein, p53 protein expressions and a high mitotic index of proliferating cell population were significant indicators of poor prognosis. >>>

Gstm1 and Gstt1 Genes are Potential Risk Modifiers for Bladder Cancer

SZ Abdel-Rahman, PhD, WA Anwar, MD, WE Abdel-Aal, MD, HM Mostafa, MD and WW Au, PhD

In patients with null alleles for both the polymorphic glutathione S-transferase genes GSTMI and GSTTI either individually or in combination the risk for developing urinary bladder cancer was greater than in cases in which both genes were present. >>>

Prognostic Significance of c-erbB-2 Gene Expression in the Poorly Differentiated Type of Adenocarcinoma of the Stomach

Yutaka Yonemura, Itasu Ninomiya, Kouichirou Tsugawa, Sachio Fushida, Takashi Fujimura, Itsuo Miyazaki, Tadao Uchibayashi, Yoshio Endou, and Takuma Sasak

Overexpression of C-erbB-2 protein in poorly differentiated gastric adenocarcinoma was closely associated with increased lymph-node metastases, a high risk for development of peritoneal dissemination and earlier deaths than in cases with C-erbB-2-negative tumors. >>>

Shared Tumor Antigens in Colorectal Carcinoma and Neuroendocrine Tumors

Martin Tobi MB, ChB, Elizabeth Darmon, MS, Paul Rozen, MBBS, Mimi Baratz, MD, Monahill Lundqvist, PhD, Kvell Oberg, MD, Peter Thomas, Ph.D, Jose Esteban, MD, Sian Hefta, Phd, Ray Paxton, Ph.D, and Jack Shively, Ph.D

Positive staining of the ND4 monoclonal antibody was found in 85% of poorly differentiated colorectal carcinomas (CRC) and in 25% of neuroendocrine tumor sections, whereas anti-CEA staining was strongly positive for 90% of CRC and 37% of carcinoids. >>>

Effects of Gamma-Glutamylcysteine Ethyl Ester in cisplatin-Induced Changes in Prostanoid Concentrations in Rat Gastric and Colonic Mucosa

H Goto, MD, K Tachi, MD, T Arisawa, MD, Y Niwa, MD, T Hayakawa, MD, and S Sugiyama, MD

In cisplatin-treated rats a significant decrease in 6-keto-PGF1alpha occurred in the gastric mucosa 24 hours after administration while no significant changes were noted in the colonic mucosa as a result of cisplatin treatment. >>>

Screening Mammography Behavior After a False Positive Mammogram

Etta D Pisano, MD, Jo Anne Earp, PhD, and Tamara Lou Gallant, MPH

A negative breast biopsy after a false-positive mammogram did not deter 73% of the women seen in a university teaching hospital's radiology clinic from seeking subsequent mammograms. >>>

Enhancement of Tumor Cell Lysis by Natural Killer Cells After Blocking of Hla-Monomorphic Determinant Using f(ab')2 Fragment of W6132

Fumio Komatsu, MD, and Michiko Kajiwara

Negative signals of natural killer (NK) cells triggered by HLA polymorphic determinant (PMD) and HLA-monomorphic determinant (MMD) of target cells were assessed by means of a blocking test. Target cell line H42 from a patient with bladder cancer after radiation therapy was PMD negative but MMD positive and NK sensitive. Cell line H41 from the same patient before radiation treatment possessed both PMD and MMD and exhibited NK resistance. Thus a negative signal may be triggered by PMD as well as MMD. >>>

Resistance of Spontaneously Transformed Syrian Hamster Embryo Cells and Their Malignant Variants to Cytotoxic Activity of Recombinant Tumor Necrosis Factor-Α

Eugene A Volpe, MD, PhD

Examination of the sensitivity of spontaneously transformed Syrian hamster embryo cells (STHE) for TNF-alpha-mediated cytotoxicity revealed that STHE cells and non-transformed normal hamster embryo fibroblasts were equally resistent to TNF-alpha concentrations. It is suggested that TNF-alpha is not the single factor responsible for invitro selection of malignant STHE cells by activated macrophages and that H202 is involved in the selection of STHE tumor cells. >>>

Herbert E. Nieburgs, MD
Worcester, MA
1998