Published in Cancer Detection and Prevention 1998; 22(1):75-86.

Transgenic Mouse Models for Tumor Suppressor Genes

Ganesh S Palapattu MDa, Shideng Bao PhDa, T Rajendra Kumar PhDa, Martin M Matzuk MD PhD a,b,c

Departments of aPathology; bCell Biology; cMolecular and Human Genetics, Baylor College of Medicine, Houston, TX

Address all correspondence and reprint requests to: Martin M. Matzuk. M.D., Ph.D., Department of Pathology. Baylor College of Medicine, Houston, TX 77030.

ABSTRACT: The identification and cloning of tumor suppressor genes has mostly relied on familial human cancer predisposition syndromes and reverse genetics. Recent advances in manipulating the mouse genome by gene targeting techniques in embryonic stem (ES) cells has led to the generation of mutant mouse models mimicking many human syndromes. Mice lacking one or both alleles of known tumor suppressor genes have been generated to evaluate the normal function of these genes in vivo. These mice have proven to be highly susceptible to tumor development, indicating that the mouse is a potent in vivo assay system for tumor suppressor genes. The initiation of gonadal tumor development in mice lacking both copies of the alpha-inhibin gene demonstrates that this assay is also useful for identifying new tumor suppressor genes. In the future, murine ES cell/gene targeting strategies will continue to be used to identify novel tumor suppressors and analyze their in vivo roles in growth control.

KEY WORDS: mouse model, oncogenesis, transgenic, tumor suppressor.

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