 |
|
Home
Journal
Online Issues
Volume 21 / Issue 6
Effects of Catechols on Free Radical Formation by Chemotherapeutic...
|
|
Published in Cancer Detection and Prevention 1997; 21(6):553-562. Effects of Catechols on Free Radical Formation by Chemotherapeutic Agents (Adriamycin, Farmorubicin, and Mitomycin)aDepartment of Phytopharmacy and Ecotoxicology, University of Avignon and INRA, Versailles, France; bResearch Department, Alexandria Institute of Medicine, Hastings-on-Hudson, NY; cClinic of General and Vascular Surgery, Pomeranian Medical Academy, Szczecin, Poland; dInstitute of Physics, Technical University of Szczecin, Szczecin, PolandAddress all correspondence and reprint requests to: Michel Bounias, D.Sc., Unite de Biomathematique et Toxicologie, Universite d'Avignon, Faculte des Sciences, 33 rue Pasteur F 84000 Avignon, France. ABSTRACT: The aim of the present study was to investigate the effects of biologically important catechols on the cytotoxicity of adriamycin, farmorubicin, and mitomycin C with respect to hydroxyl radical production. Catecholamines (adrenaline, noradrenaline, dopamine) and DOPA enhance the generation of hydroxyl radicals by chemotherapeutic antibiotics. Measures were done using a deoxyribose assay, in presence of the Co(II) + H2O2 system. Catalase and hydroxyl radical scavengers (mannitol, thiourea, cysteine, glutathione, L-lactic dyhydrogenase) inhibited the deoxyribose damage caused by the drugs. KEY WORDS: adriamycin, catecholamines, farmorubicin, hydroxyl radical, mitomycin C. For more information, contact klich@arcadia.iter.tuniv.szczecin.pl |
Site Contents
|