Cancer Detection and Prevention Volume 21 / Issue 4 (Jul-Aug 1997)

Table of Contents and Editor's Notes

The peer review process occasionally results in approval of controversial publications that do not necessarily reflect the viewpoint of the editors. Readers of the journal are encouraged to critically review and comment on presented data by submitting a "Letter to the Editor" that may be reprinted in a subsequent issue.

Elimination of Intercellular Junctional Communication Requires Lower Ras 1eu61 Levels Than Stimulation of Anchorage-Independent Proliferation

Heather L Brownell, James F Whitfield, Leda Raptis

Expression of increasing amounts of activated rasleu61 eliminated gap junctional intercelluar communication at substantially lower levels than required for neoplastic transformation. >>>

Detection of Membrane-Associated Human Chorionic Gonadotropin and its Subunits on Human Cultured Cancer Cells of the Nervous System

Hernan F Acevedo PhD, Robert J Hartsock MD, Joseph C Maroon MD

Membrane-associated and cytoplasmic human chorionic gonadotropin (hCG), its subunits and its fragments were present in human cancer cells of neuroblastomas, medulloblastomas, retinoblastomas, and malignant gliomas of nude mice. >>>

Investigation of Vicia graminea Lectin- And Vicia unijuga Lectin-Binding Glycoprotein as Novel Oncofetal Antigens in Cyst and Ascitic Fluids of Human Ovarian Tumors in Benign, Dysplastic, and Malignant Stages

Kunjo Ohyama PhD, K Yanagi, S Hayashi, T Matsuda, R Suzuki, S Ohkuma, H Watanabe, S Hirakawa, T Yamakawa

The degree of malignancy of ovarian tumors was determined from examination of the glycoprotein fractions. >>>

The Enhancing Effect of Sodium Nitrite on Virus-Induced Leukemia in Mice

Andrei P Ilnitsky MD, Anna S Kolpakova

Sodium nitrite in the drinking water at levels of 10.0, 100.0 and 400.0 maximum admissible concentration accelerated the development of Rauscher Leukemia virus-induced leukemia in mice. >>>

Dna Content and Thymidine Labeling Index Correlate with Prognosis in Squamous Cell Carcinoma of the Larynx

L Matturri MD, B Biondo ScD, P Tamplenizza MD, A Ottaviani M.D, AM Lavezzi MD

In 48 cases of squamous cell carcinoma of the larynx the thymidine labeling index was a more important predictor of survival (p=0.015) than prognostic DNA values and tumor stage. >>>

Detection of p53 Nuclear Protein Accumulation in Brushings and Biopsies of Barrett's Esophagus

Thomas T Tsai BS, Philip F Bongiorno,MD, Mark B Orringer MD, David G Beer PhD

Nuclear accumulations of altered p53 protein were detected by immunohistochemistry in specimens from patients with Barrett esophagus but not in those with a normal esophagus. >>>

Cell-Cycle Arrest in Goigi Phase of Growth Factor-Induced Endothelial Cell Proliferation by Various Calcium Channel Blockers

Heike Zeitler MD, Yon Ko MD, Bernhard Glodny MD, Gudrun Totzke PhD, Marianne Appenheimer, Agapios Sachinidis PhD, Hans Vetter MD

Calcium channel blockers verapamil, nifedipine, diltiazem and isradipine arrested basic fibroblast growth factor induced human umbilical arterial endothelial cell proliferation. Israpidine seemed the most potent antiproliferative agent. >>>

Preventive Effect of 1-(2-Tetrahydrofuryl)-5-Fluorouracil in Combination with Uracil on Colonic Carcinogenesis Induced by 1 ,2-Dimethylhydrazine in Rats

Shinobu Sakamoto MD, Yasuyuki Kawachi MD, Takeo Iwama MD, Kunio Tsukada MD, Tetsuro Sagara MD, Saburo Murakami MD, Hideki Kudo MD, Isao Okayasu MDC

Weekly subcutaneous injections of 1,2-dimethethyhydrazine into 6-week-old rats markedly increased thymidylate synthetase (TS) in the poorly differentiated, and thymidine kinase in the well-differentiated adenocarcinomas of the colon. Oral administration of 5FU combined with Uracil markedly reduced the number of accumulated colonic carcinoma areas and decreased the TS activity in the poorly differentiated carcinomas. >>>

Analysis of Specific Accumulation of Radiolabeled Anti-Carcinoembryonic Antigen Monoclonal Antibody Cea1o2 in Colorectal Cancer Using Computed Radiography

Tadashi Watanabe MD, Tsuyoshi Satoh, Masanori Tadokoro, Junichi Sakamoto, Hiroki Murayama. Katsuki Ito, Sadayuki Sakuma, Hiroshi Takagi

Intravenously injected radiolabeled anti-carcinoembryonic antigen monoclonal antibody into patients with colorectal cancer accumulated specifically in primary tumors, liver metastases, disseminated tumors and metastatic lymph nodes. >>>

Epidermal Growth Factor Receptor in Human Hepatocellular Carcinoma

Keisuke Hamazaki MD, Yasuhiro Yunoki MD, Hisashi Tagashira MD, Takuji Mimura MD, Masanobu Mori MD, Kunzo Orita MD

The level of epidermal growth factor receptor (EGFR) was significantly decreased in hepatocellular carcinoma compared to noncancerous liver tissue. No significant differences in EGFR were observed between diploid and aneuploid tumors, and between EGFR levels and tumor diameter, extracapsular infiltration or portal invasion. >>>

The Association of Ethnicity and the Incidence of Mammary Carcinoma in Situ in Women: 11,436 Cases From the California Cancer Registry

Sidney L Saltzstein MD MPH

White women had the highest annual age-adjusted incidence of mammary carcinoma in situ (CIS). White and Asian/Other women had a significant higher percentage of tumors detected in the CIS stage than Hispanic or Black women. There was a significant difference between the CIS percentages of women in the high socioeconomic status (SES) compared to the low SES groups for all except Black women. >>>

Providing Information About Breast Cancer Via Public Forums

Analee E Beisecker Ph.D, Jeanne Hayes MPA, Janet K Ashworth MA, Penny L Reese MA

Health professionals had improved knowledge of breast cancer after attending an educational conference as well as through distribution of printed materials. Lay persons had greater long-term gain in knowledge after attending an educational conference than through distribution of printed matter. >>>

Employee Response to a Company-Sponsored Program of Colorectal and Prostate Cancer Screening

Ronald E Myers PhD DSW, Sally W Vernon PhD, Arvind V Carpenter,DDS Dr PH, Andrew M. Balshem BA, Philip G Lewis MD MPH, Thomas A Wolf MA, June Hilbert RN, Lester R. DeFonso BA, Eric A Ross ScM

Information sent to current and former employees of a chemical plant on the increased rates of leukemia, respiratory, prostate, bladder and pancreatic cancer from the use of bis-chloromethyl ether, and on workplace-sponsored screening examination, lead to a 13 percent response. Of the responders, 31 percent had a screening examination. Responders were older, male, white and tended to have more formal education than nonresponders. >>>

Herbert E. Nieburgs, MD
Worcester, MA
1997