Cancer Detection and Prevention Volume 21 / Issue 2 (Mar-Apr 1997)

Table of Contents and Editor's Notes

The peer review process occasionally results in approval of controversial publications that do not necessarily reflect the viewpoint of the editors. Readers of the journal are encouraged to critically review and comment on presented data by submitting a "Letter to the Editor" that may be reprinted in a subsequent issue.

Delayed Cytocidal Effect of Lignin Derivatives on Virally Transformed Rat Fibroblasts

K. Sorimachi, PhD K. Akimoto A. Niwa, MD and Y. Yasumura, MD

Growth of rat fetus fibroblasts transformed with adenovirus type 12 was strongly inhibited when cultured with lignin derivatives (acetyl or sulfonyl), possibly caused by a deficiency of an essential nutrient in the culture medium. >>>

Effects of Lycopene-Enriched Tomato Oleoresin on 7,12-Dimethyl-benz[a]anthracene-Induced Rat Mammary Tumors

Y. Sharoni, PhD, E. Giron, MSc M. Rise, PhD and J. Levy, PhD

In 7,12-dimethyl-benz[a]anthracene (DMBA)-induced rat mammery tumors lycopene-enriched tomato oleoresin reduced the number and size of tumors, while beta-carotene had no effect. Report is in keeping with epidemiologic findings of a protective effect of lycopene-rich diet on pancreatic and bladder cancer. >>>

Comparative Studies of Cam 123-6 and Carcinoembryonic Antigen for the Serological Detection of Pulmonary Adenocarcinoma

N. Kohno, MD, Y. Hirasa, MD, K. Kondo, MD, S. Fujioka, MD, S. Fujino, MD, M. Abe, MD, A. Yokoyama, MD K. Hiwada, MD, K. Watanabe and J. Nishimura

The diagnostic value of the tumor marker CMA 123-6 was similar to that of CEA for pulmonary adenocarcinoma. Squamous cell carcinoma antigen levels were highest for squamous cell carcinoma and neuron-specific enolase for small cell carcinoma. >>>

Differential Reduction in the Expression of Keratin Polypeptides in Human Gastric Carcinomas

A. Gupta, PhD T. Malati, PhD, and P.D. Gupta, PhD

Gastric adenocarcinoma had absence of tonofilament bundles, increase in mitochondria and reduction to only 2 keratin polypeptide bands as compared to the normal gastric epithelium with 4 keratin polypeptide bands. >>>

Aberrant Crypt Foci in Human Colon Carcinogenesis

P. Dolara, MD G. Caderni, PhD L. Lancioni, MS A. Giannini, MD, A. Anastasi MD M. Fazi MD and G. Castiglione, MD

Examination of aberrant crypt foci (ACF) and progression from ACF to adenocarcinoma and cancer is useful for experimental carcinogenesis but not for early detection of colon cancer in humans. >>>

Evidence of Gender Bias in Patients Undergoing Flexible Sigmoidoscopy

A.H. Herold, MD A.I. Riker, MD E.A. Warner MD, L.J. Woodard, MD , H.J. Brownlee, Jr., MD, D. Pencev, MD, R.J. Oldenski, MD and P.G. Brady, MD

Study of 1910 patients revealed a gender bias against women undergoing flexible sigmoidoscopy for both, screening and diagnosis. Forty-five percent of the patients who underwent colonoscopy were females. >>>

Consecutive Maintenance of Human Solitary and Hereditary Colorectal Polyps in Scid Mice

Kawaguchi, MD, H. Nakajima, PhD, T. Hongyo, MD PhD, K. Fukuda, MD, Eiji Taniguchi, MD, K. Sutoh, BPharm, Hui Wang, MD, P. Hande, PhD, Li Ya Li, MD, M. Kurooka, MD, T. Iwasa, BS, N. Kurokawa, PhD, R. Nezu, MD, M. Miyata, MD PhD, H. Matsuda, MD PhD and T. Nomura, MD PhD

In transplanted colorectal polyps and cancer to sever combined immunodeficient mice, the average doubling time of polyps was about 10 times longer than that of colorectal cancer. K-ras mutations were detected predominantly at codon 12. Loss of heterozygosity was noted in all xenografts. >>>

Β - 4 Integrin Subunit Expression is Downregulated in Low Metastatic Carcinoma Variants

L. Cimino, PhD, D. Perrotti, MD, G. D'Agostino, PhD, R. Falcioni, PhD, and A. Sacchi, PhD

In murine carcinoma lines the 7-kb full-length beta-4 transcript was associated only with highly metastatic cells. Low metastatic cells had reduced expression and shorter transcripts of the beta-4 protein. >>>

Detection of Melanoma by Monitoring the Intracellular Fluorescein Fluorescence Polarization Changes in Lymphocytes

Merimsky, MD, M.Oncol.,. B. Kaplan, MD, M. Deutsch, PhD, R. Tirosh, Ph D, A. Weinreb, PhD, and S. Chaitchik, MD

Thirty-five of 46 patients with active melanoma in stages I and II were detected by intracellular fluorescein fluorescent polarization (IFFP) of the structuredness of cytoplasmic matrix responding lymphocytes, while only half of the 11 patients in stage III were positive. The sensitivity and specificity for detection of melanoma by IFFP test were 73.9% and 90.6% respectively. >>>

Metabolism, Uptake, and Excretion of a D-Glucaric Acid Salt and its Potential Use in Cancer Prevention

Z. Walaszek, PhD, J. Szemraj, PhD, M. Narog, MD, A.K. Adams, BS, J. Kilgore, BS, U. Sherman, MS, and M. Hanausek, PhD

D-glucaric acid found in some fruits and vegetables was transformed in the stomach of rats to D-glucaro-1.4 lactone (1.4 GL) that increases detoxification of carcinogens and tumor promoters by inhibiting beta-glucuronidase. >>>

Antiblastic Chemotherapy Drugs Up-Modulate Interferon-Y Receptor Expression on Human Malignant T Cells

F. Novelli, PhD, A. Allione, PhD, P. Bernabel, PhD, L. Higamonti, PhD, and G. Forni, MD

Timely combination of chemotherapeutic drugs, etoposide, cisplatin, daunomycin and cytarabin, with administration of interferon (IFN-gamma) induced apoptosis by markedly increasing IFN-gamma expression. >>>

Synaptonemal Complex Damage in Mouse Spermatocytes Exposed to Tequila and Brandy

A. Pina-Calva, MS, R. Quezada-Medina, Biol., and E. Madrigal-Bujaidar, DS

The alcoholic beverage, tequila and brandy, in high concentration and cyclophosphamide induced significant damage to male mouse spermatocytes. >>>

Herbert E. Nieburgs, MD
Worcester, MA
1997