ISPO

Published in Cancer Detection and Prevention 1997; 21(1):7-11.

Deletion of Chromosome 11 and Development of Colorectal Carcinoma

Atsushi Nanashima, MD, Yutaka Tagawa, MD, Toru Yasutake, MD, Naoki Fujise, MD, Kiyotaka Kashima, MD, Tohru Nakagoe, MD, Hiroyoshi Ayabe, MD

First Department of Surgery, Nagasaki University School of Medicine, Nagasaki-City, Nagasaki, Japan

Address all correspondence and reprint requests to: Atsushi Nanashima, MD, First Department of Surgery, Nagasaki University School of Medicine, 7-1 Sakamoto 1- Chome, Nasaki-City, Nagasaki, 852 Japan

ABSTRACT: The deletion of chromosome 11q is observed frequently in tumors of the large intestine. To investigate the relationship between aberrations of chromosome 11 and histopathological features of colorectal carcinoma, we examined the frequency of chromosome aberrations using fluorescence in situ hybridization to 29 short-term cultured cells from surgical specimens. Numerical aberrations were not related were not a deletion of chromosome 11 was frequently observed in larger (>= 5 cm) and more invasive tumors (>= T3 category) (p <0.05). Furthermore, the incidence of aberrations tended to increase in Dukes' B. Although translocation of chromosome 11 was also found in 17% of cases, it was not associated with histopathological features. Our findings indicate that the deletion of chromosome 11 is closely related to the progression of colorectal carcinoma.

KEY WORDS: large intestine, short-term culture, fluorescence in situ hybridization, chromosome painting.

http://www.cancerprev.org/Journal/Issues/21/1/163