Published in Cancer Detection and Prevention 1997; 21(1):1-6.

Tubal Ligation and the Risk of Ovarian Carcinoma

Terri L Cornelison MD1, Nachimuthu Natarajan MS2, M Steven Piver MD1, Curtis J Mettlin PhD2

Departments of 1Gynecologic Oncology, and 2Cancer Control and Epidemiology, Roswell Park Cancer Institute, Buffalo, NY

Address all correspondence and reprint requests to: M. Steven Piver, MD, Department of Gynecologic Oncology, Elm and Canton Sts., Buffalo, NY 14263

ABSTRACT: To assess the relationship of tubal ligation and risk of ovarian carcinoma, we conducted a case-control, retrospective analysis of 300 ovarian carcinoma cases and 606 nonmalignant disease controls, seen between 1982 and 1988 at Roswell Park Cancer Institute, Buffalo, New York. Women who had a tubal ligation had reduced risk for the development of ovarian cancer. This relative risk was 0.52, with a 95% confidence interval 0.31 to 0.85 (p = 0.0076). Controls were matched by age. Multivariate analysis adjusted for socioeconomic level, marital status, parity, age at first pregnancy, menarche age, menopause age, irregular menses, breast-feeding duration, body habitus, and oral contraceptive use. Suggested explanations for this observation are offered.

KEY WORDS: tubal ligation, ovarian cancer.