Cancer Detection and Prevention Volume 20 / Issue 4 (Jul-Aug 1996)

Table of Contents and Editor's Notes

The peer review process occasionally results in approval of controversial publications that do not necessarily reflect the viewpoint of the editors. Readers of the journal are encouraged to critically review and comment on presented data by submitting a "Letter to the Editor" that may be reprinted in a subsequent issue.

bcr Gene Rearrangement Analysis in Myeloproliferative Disorders Other Than Chronic Myelogenous Leukemia

Domnita Crisan, M.D., Ph.D., Joan C. Mattson, M.D., Barbara A. O'Malley, M.D., Rex W. Schulz, M.D., Freeman Wilner, M.D.

The bcr gene, diagnostic for chronic myelogenous leukemia, was absent in 36 of 37 patients with myeloproliferative disorders. >>>

p53 Mutations in Head and Neck Squamous Cell Carcinomas From Sudanese Snuff

Philip Lazarus, Ph.D., Ali M. Idris, D.D.S., Jenny Kim, B.S., Ana Calcagnotto, M.S., Deitrich Hoffmann, Ph.D.

Toombak-snuff users in Northern Sudan exhibited mutations in the p53 gene as determined by the PCR and DNA sequencing. >>>

Cytotoxicity of Bleomycin and External Radiation in Squamous Cell Cancer Cell Lines of Head and neck*

Hilkka A. Jaaskela-Saari, M.D., Kalevi J. A. Kairemo, M.D., M.S., Antti P. Jekunen, M.D., Kirsi Pekkola-Heino, M.D., Jarmo Kulmala, M.S., Hans A. Ramsay, M.D., Reidar Grenman, M.D.

Five cell lines from patients with head and neck squamous cell carcinoma were sensitive to both Bleomycin and external radiation utilizing the 96-well clonogenic assay. >>>

Quantitative Cytology and Thyroperoxidase Immunochemistry: New Tools in Evaluating Thyroid Nodules by Fine-Needle Aspiration

Michel Pluot, M.D., Marie-Jose Faroux, C.T. , Jean- Bernard Flament M.D., Martine Patey, M.D., Serge Theobald, M.D. and Marie-Joelle Delisle, M.D.

Fine-needle aspiration of cold thyroid nodules in 776 patients revealed 94% sensitivity and 80% specificity. Use of a new monoclonal antiperoxidase antibody immunostaining was associated with 97% sensitivity and 81% specificity. >>>

Dietary Calcium Salts as Protective Agents and Laminin P1 as a Biochemical Marker in Chemically Induced Colon Carcinogenesis in Rats

S. Belbraouet, Ph.D., F. Felden, M.D., Ph.D., X. Pelletier, Ph.D., I. Gastin, M.D., D. Lambert, Ph.D., J. Floquet, M.D., J.L. Gueant, M.D., Ph.D., and G. Debry, M.D.

A supplemented diet of either calcium lactate or gluconate inhibited nitrosomethylurea-induced carcinogenesis in Wistar rats on a high-fat diet. Laminin P1 levels were higher in supplemented than in non-calcium-supplemented rats. >>>

Detection of Colon Cancer by Monitoring the Intracellular Fluorescein Fluorescence Polarization Changes in Lymphocytes

Ofer Merimsky, M.D., Mordechai Deutsch, Ph.D., Reuven Tirosh, Ph.D., Ishai Wohl, M.D., Arye Weinreb, Ph.D., Samario Chaitchik, M.D.

The structuredness of cytoplasmic matrix (SCM) of stimulated lymphocytes discriminated between people and patients even with locoregional colorectal cancer. The SCM test also distinguished Duke C patients from those with metastasis. Distribution of intracellular fluorescein fluorescence polarization values and their ratios differed according to whether the lymphocytes were from healthy subjects or from colorectal cancer patients. >>>

Intercellular Adhesion Molecule-1 Release From Human Hepatocellular Carcinoma

Ichinosuke Hyodo, M.D., Ph.D., Kenli Jinno, M.D., Ph.D., Masahito Tanimizu, M.D., Ph.D., Toshihiko Doi, M.D., Ph.D., Yoshiyuki Nishikawa, M.D., Yasushi Hosokawa, M.D., Ph.D., Shosuke Moriwaki, M.D., Ph.D.

Patients with chronic hepatitis, liver cirrhosis and hepatocellular carcinoma had significantly higher serum levels of E-selectin, vascular cell and intercellular adhesion molecule-1 than normal controls. >>>

Skin Cancer Prevention, Early Detection, and Management: Current Beliefs and Practices of Australian Family Physicians

Atat Girgis, Ph.D., and Rob W. Sanson-Fisher, Ph.D.

The most likely factors that discourage screening of patients for skin cancer were determined from a mail survey of family physicians. Replies from 97 physicians included lack of time in 32%, forgetting in 26%, no financial incentives in 20%, lack of patient screening history in 14% and inability to convince patients who refuse in 13%. >>>

What Use Do People Make of Physicians in Checking Their Skin for Cancer?

C.B. Del Mar, F.R.A.C.G.P., F.A.F.P.H.M., W.R. Stanton, Ph.D., A.M. Gillespie, Ph.D., J. B. Lowe, Ph.D., K.P. Balanda, Ph.D.

In response to a questionnaire administered to 995 randomly selected people, 739 stated that their skin was examined by a physician, by themselves or both. Of 15% who were taught to examine their skin, 59% learned to do so from physicians. Examination of their skin for cancer was regarded as very beneficial by 90%, as reassuring by 88%, embarrassing by 5% and inconvenient by 37%. >>>

Trends in Mammography Use and Their Relation to Physician and Other Factors

Dorothy S. Lane, M.D., M. P. H., Lee S. Caplan, M.D., M. P. H., Ph.D., Roger Grimson, Ph.D.

A mail survey of a random sample of over 2000 women 50 to 75 years of age, residing in Long Island, revealed significant increases in reported mammography use over a 3-year period within all age, income and educational subgroups. The percentage of women who ever had a mammogram increased from 51 to 73%. Clinical breast examination was the strongest predictor of mammography. >>>

Attitude of Women Towards Early Cancer Detection and Estimation of the Compliance to a Screening Program for Cervix and Breast Cancer

Luigina Bonelli, M.D., Margherita Branca, M.D., Maddalena Ferreri, Ph.D., Daniela Barizzone, M.S., Emilia Rossi, M.D., Sabina Cedri, M.S., Paolo Bruzzi, M.D., and Leonardo Santi, M.D.

The attitude towards early detection of cervical and breast cancer was determined from interviews with 349 women who were randomly selected. The PAP test had been performed once a year in 197 of 349 women (56.4%). The estimated participation in the cervical cancer screening program was indicated by 222 of 349 women (63%). Previous mammography was reported by 49.3% of women aged 50 to 69 years, who never had experienced breast-related syndromes. The intention to participate in the breast cancer screening program was expressed by 98 of 166 women (59%). >>>


Herbert E. Nieburgs, MD
Worcester, MA