Cancer Detection and Prevention Volume 20 / Issue 3 (May-Jun 1996)

Table of Contents and Editor's Notes

The peer review process occasionally results in approval of controversial publications that do not necessarily reflect the viewpoint of the editors. Readers of the journal are encouraged to critically review and comment on presented data by submitting a "Letter to the Editor" that may be reprinted in a subsequent issue.

Normal Cell Decline and Inhibition in Acute Leukemia: A Biomathematical Modeling Approach

Evans K. Afenya, ph.D., and Calixto P. Calderon, Ph.D.

A biomathematical model is used to predict inhibition of normal cell growth in the presence of leukemia cells. >>>

Positive Reaction of Monoclonal Antibody (T073) with Resistant Leukemic Cells

Toshio Kakihara, M.D., Toshiyuki Yamada, M.D., Takeaki Fukuda, M.D., Makoto Naito, M.D., Makoto Uchiyama, M.D., and Iwao Emura, M.D.

Drug resistance was determined by use of an MDR leukemia cell line KY-VCR and monoclonal antibody T073. The antibody reacted with chemotherapy resistant leukemia cells whereas none of the normal cells were stained with T073. >>>

Detection of Residual Leukemic Cells in (B-All) by a Nonradioactive PCR-Based Technique

U. Lendeckel, T. Wex, K. Frank, A. Daoud, A. Franke, and S. Ansorge

In B-cell acute lymphoblastic leukemia, hybridization of digoxigenin DIG-labeled oligonucleotide clone-specific probes during therapy permitted the detection of residual leukemic cells in bone marrow specimens. >>>

Cytotoxicity of nacl, A Stomach Tumor promoter, And Prevention by Rice Extract in Stomach Mucosa of F344 Rats

Chie Furihata, Ph.D., Shizuka Ishida, B.S., Hiroyoshi Ohta, M.D., Takashi Tokuyama, Ph.D., Tsutomu Katsuyama, M.D., and Zen-ichi Ogita, Ph.D.

Feeding of NaCl to male Fischer rats induced destruction of surface cells in the pyloric mucosa and increased replicative DNA synthesis. Prior administration of aqueous rice extract prevented tissue damage and the increase in replicative DNA synthesis. >>>

Tumor Cells Engineered to Express Major Histocompatibility Complex Class Ii Molecules Induce T Helper Cell-Dependent Responses That Protect Mice From Normally Lethal Doses of Unmodified Tumor Cells

Gerald N. Callahan, Ph.D., and Dana R. Leach, D.V.M.

Female A/J mice failed to grow tumors when inoculated with fibrosarcoma cells that were transfected with genes encoding either syngeneic or allogeneic major histocompatibility class II molecules. No tumors were induced even when mice were give 10 times the number of tumor cells that were normally sufficient to produce tumors in the majority of infected mice. >>>

Ex Vivo Cytokine Production by Whole Blood Cells From Cancer Patients

Donat De Groote, Ph.D. , Yvonne Gevaert, B.S., Miguel Lopez, B.S. , Renee Gathy, B.S., Francoise Marchal, M.D., Bernard Detroz, M.D., Nicolas Jacquet, M.D., and Vincent Geenen, M.D.

Production of cytokines, interferon-gamma, granulocyte-monocyte colony stimulating factor and leukemia inhibitory factor was impaired in blood of untreated patients with different types of cancer prior to surgery using enzyme-linked immunosorbent assays. >>>

Absence of p53 Mutations in Methylnitrosourea-Induced Mammary Tumors in Rats

Katsuhiro Ogawa, M.D., Yoshihiko Tokusashi, M.D., and Ikue Fukuda, M.D.

In methylnitrosourea-induced rat mammary tumors the mutation in p53 exons 5 through 8 were not identified in contrast to the frequent p53 mutations in human breast tumors. >>>

Point Mutation of the p53 Gene is an Infrequent Event in Untreated Prostate Cancer

Kazuto Kunimi, M.D., M.M.Sc., Toshiyasu Amano, M.D., and Tadao Uchibayashi, M.D.

Point mutation of the p53 gene was observed in only 1 of 18 patients with untreated prostate cancer. and testicular tumors. >>>

Cancer Knowledge and Perceptions Among Chinese Factory Workers: Implications for Cancer Control and Prevention

Sonja L. Myhre, M.S. P. H., Virginia C. Li, Ph.D., Ji-hui Guan, M.D., and Zhi Jin Wang, M.B.

Knowledge and attitude towards a variety of cancer issues was determined by a questionnaire issued to a random sample of Chinese factory workers. The overall response indicated lack of knowledge about cancer risk factors, cancer warning signs and harmful occupational exposures. >>>

Nutritional, Socioeconomic, and Reproductive Factors in Relation to Female Breast Cancer Mortality: Findings From a Cross-National Study

James R. Hebert, SC.D., and Alicia Rosen, M.S., R.D.

Data from 66 countries revealed a strong association of breast cancer risk and mortality with dietary factors, especially animal products and independent of caloric intake, consumption of saturated and unsaturated fat, dietary protein and hormone levels. Other risk associations are reproductive factors, benign breast disease and family history of breast cancer. Protective effects are exerted by vegetarian diets, cruciferous vegetables, cereal products, dietary fiber and increased fertility. >>>

Melanoma Mortality in Middle-Aged and Older Men, and Older Women in New Zealand

Kenneth R. Cooke, M.B.Ch.B., Ph.D., F.A.F.P.H.M.

Analysis of 964 melanoma registrations in 1983 to 1984 revealed that response to early detection education and duration of symptoms prior to diagnosis was longer in men aged 55 or older than in younger men while older women had shorter durations of symptoms than younger women. Mortality rates from 1949 to 1989 in men increased 6.8 fold while rates for women increased 3.5 fold. Age-adjusted ratios of mortality during the same period among middle-aged and older men and women increased at a disproportionately high rate relative to younger age groups. >>>

Neuroblastomas Presenting in the First Year of Life: Epidemiological Differences From Those Presenting At Older Ages

Niels L. T. Carlsen, M.D.

Presentation of neuroblastoma before 1 year of age was associated with multiple primary tumors, absence of hereditary disease in the infant and families, younger parents, lower socioeconomic status and complicated pregnancies. Presentation of disease after the first year of life was linked to a much smaller number of multiple primary tumors, greater number of hereditary diseases in patients and family members, older parents and less complicated pregnancies. >>>


Herbert E. Nieburgs, MD
Worcester, MA