Cancer Detection and Prevention Volume 20 / Issue 2 (Mar-Apr 1996)

Table of Contents and Editor's Notes

The peer review process occasionally results in approval of controversial publications that do not necessarily reflect the viewpoint of the editors. Readers of the journal are encouraged to critically review and comment on presented data by submitting a "Letter to the Editor" that may be reprinted in a subsequent issue.

Activity of the DNA Repair Protein 0(6)-Methylguanine-DNA Methyltransferase in Human Tumor and Corresponding Normal Tissue

I. Preuss , S. Haas , U. Eichhorn , I. Eberhagen , M. Kaufmann , T. Beck , R. H. Eibl , P. Dall , T. Bauknecht , J. Hengstler , B. M. Wittig , W. Dippold and B. Kaina

The DNA repair protein 0(6)-methylguanine-DNA methyltransferase (MGMT) content in 11 of 12 breast tissues exceeded that of normal tissue. The highest activity was found in colon carcinomas, followed by ovarian tumors, breast carcinomas and testicular tumors. >>>

Preliminary Report: The Short-Term Effects of Direct p53 DNA Injection in Primary Hepatocellular Carcinomas

N. A. Habib, Ch.M., F.R.C.S. , S.-F. Ding, M.D., Ph.D. , R. El-Masry, M.D., F.R.C.S. , R. R. Mitry, B.S. , K. Honda, M.D. , N. E. Michail, M.D., G. Dalla Serra, M.D. , G. Izzi, M.D. , L. Greco, M.D. , M. Bassyouni, M.D. , M. El-Toukhy, M.D. , and Y. Abdel-Gaffar, M.D.

Five patients with primary hepatocellular carcinoma and cirrhosis due to viral hepatitis were treated with wild-type p53 injection. Three of the five patients responded by reduction of the tumor volume and by a significant decrease in serum alphafetoprotein. >>>

Risk Factors for Breast Cancer Mortality Among the National Breast Screening Study of Canada Participants

Mary C. Busetti, M.D., M.S. , Anthony B. Miller, M.D., F.R.C.P. , Teresa To, Ph.D. and Thomas E. Rohan, M.B., Ph.D.

In the Canadian National Breast Study of 84 cases and 420 controls of woman aged 40 to 59 years, the risk of dying from breast cancer was increased in women who had never been pregnant, who never had a live birth and who never had been married. No association of breast cancer was found with either oral contraceptive use, hormone replacement therapy or smoking. >>>

Inhibition of Hepatocellular Carcinoma Development and Erythrocyte Polyamine Levels in Ods Rats Fed on 3'-Methyl-4-Dimethylaminoazobenzene by Hemicalcium ascorbate, 2-0-Octadecylascorbic acid, And Ascorbyl Palmitate

Kan Shimpo, Ph.D., Hisahide Takahashi, Ph.D., Hiroyuki Tsuda, M.D., Ph.D., Tsutomu Hibino, Ph.D., Kaoru Kawai, Ph.D., Chiharu Kimura, B.S., Toshiharu Nagatsu, M.D., Ph.D., and Keisuke Fujita, M.D., Ph.D.

The anticancer effects of ascorbic acid derivatives were evaluated in ODS rats with 3'methyl-4-dimethylaminoazobenzene (3'MeDAB)-induced hepatocellular carcinoma (HCC). The study revealed that hemicalcium ascorbate and its lipophilic derivatives inhibited HCC and that increased RBC polyamine levels may serve as markers of hepatocarcinogenesis. >>>

Effect of Gonadotropin-Releasing Hormone Analogs and Their Conjugates on Gonadotropin-Releasing Hormone Receptor-Positive Human Cancer Cell Lines

Istvan Palyi, D.S. Borbala Vincze, Ph.D. , Adrienn Ka1nay, M.S. , Gizella Turi, Ph.D. , Imre Mezo, Ph.D. , Istvan Teplan, DS. , Jinos Seprodi, Ph.D. , Janos Pato, Ph.D. , and Melinda Mora, Ph.D. .

The antitumor effect of a new gonadotropin-releasing hormone (GnRH) antagonist after conjugation with a carrier macromolecule inhibited cloning efficiency and proliferation of human malignant cell lines. >>>

Genetic Instability as a Basis for Transformation of Human Lymphocytes Infected with Human Retrovirus

Koshi Maruyama, M.D., Ph.D., Shigenobu Mochizuki, Ph.D., Kiyoko Kawamura, M. T., and Nobuko Koshikawa, M.T.

Peripheral blood lymphocytes of a seronegative male underwent malignant transformation when cocultivated with iododeoxyuridine-treated HTLV1 ultraviolet irradiated cells from an adult T-cell leukemia patient. >>>

Use of Gene Marking in Bone Marrow Transplantation

Helen E. Heslop, M.D. , Cliona M. Rooney, Ph.D., Donna R. Rill, B.S. Robert A. Krance, M.D. and Malcolm K. Brenner, M.D.

Disease recurrence as a result of residual malignant cells after autologous bone marrow transplantation (BMT) for AML and neuroblastoma was determined by neomycin-resistance gene marking of the marrow at the time of harvest and identification of the marker gene and the leukemia-specific marker after relapse. >>>

The Oncofetal Protein P65: A New Member of the steroid/thyroid Receptor Superfamily

Malgorzata Hanausek, Ph.D., Janusz Szemraj, Ph.D., Alan K. Adams, B.S., and Zbigniew Walaszek, Ph.D.

The 65-KDa oncofetal protein (p65) has been identified as a new member of the steroid/thyroid superfamily of genes with as yet unknown ligand. It is suggested that the p65 receptor may play an important role in the development of tumors. >>>

Assessment of Major Carcinogenic Tobacco-Specific N-Nitrosamines in Thai Cigarettes

Klaus D. Brunnemann , Eugene J. Mitacek , Yin Liu , Thira Limsila ,and Maitree Suttajit

A high content of cancer-causing tobacco-specific N-nitrosamines (TSNA) in mainstream smoke of commercially produced Thai cigarettes from dark tobacco correlated with seasons of tobacco growth with highest levels in August through September. The highest levels of TSNA in mainstream smoke were found in cigarettes from dark tobacco without a significant decrease in filter cigarettes. >>>

Retrospective Epidemiologic Analysis of Patients Diagnosed with Intracranial Meningioma From 1977 to 1990 At the Jackson Memorial hospital, Sylvester Comprehensive Cancer Center: The Jackson Memorial Hospital Tumor Registry Experience

Lynn G. Feun, M.D., William A. Raub, Jr., Howard J. Landy, M.D., Barth Green, M.D., Aaron Wolfson, M.D., and Arnold Markoe, M.D.

The putative causes of intracranial meningiomas included smoking, alcohol, head injuries, sex hormones and the strongest correlation with ionizing radiation. Surgically-treated patients with benign intracranial meningiomas had a 5-year survival rate of 80%. The trend for survival of young patients (18 to 55 years) was better than for those older than 55 years. >>>

Effects of Alprazolam on the Development of Moloney Sarcoma Virus-Induced Tumors in Stressed Mice

Manuel Freire-Garabal, M.D., Maria J. Nunez-lglesias, M.D., Jose L. Balboa, M.D., Jose C. Fernandez-Rial, M.D., Luis Garcia- Vallejo, M.D., and Manuel Rey-Mendez, Ph.D.

Growth and incidence of Moloney Sarcoma virus (MSV)-induced tumors were evaluated in stressed female BALB/c mice. Sound anxiety-stress after MSV i.m. inoculation increased tumor growth that was inhibited by Alprazolam. Mice exposed to stress before MSV injection had decreased tumor size and incidence. >>>

In Vivo Studies of New Gonadotropin-Releasing Hormone Antagonist-Copolymer Conjugates Having Antitumor Activity

Borbala Vincze, Ph.D., Istvan Palyi, D.S., Dezso Gaal, Ph.D. , Janos Pato, Ph.D. , Melinda Mora, Ph.D. , Imre Mezo, Ph.D. , Istvan Teplan, D.S. and Janos Seprodi, Ph.D

The in vitro determined anti-tumor effects of the gonadotropin-releasing hormone (GnRH) antagonists in macromolecule conjugated form inhibited tumor growth by 40 to 44% in xenografted mice and in mouse mammary tumors. >>>


Herbert E. Nieburgs, MD
Worcester, MA