Published in Cancer Detection and Prevention 1996; 20(1):57-62.

Urinary 1-hydroxypyrene, A Pah Biomarker in Foundry Workers

O Omland, M.D.a,d, D. Sherson, M.D.b, A. M. Hansen, Ph.D.c, T. Sigsgaard, M.D., Ph.D.d, H. Autrup, Ph.D.d, and E. Overgaard, M.D.b

a Department of Occupational Medicine, Aarhus University Hospital, Aarhus, Denmark; b Department of Occupational Medicine, Vejle County Hospital, Vejle, Denmark; c Department of Chemistry and Biochemistry, National Institute of Occupational Health, Copenhagen, Denmark; and d Department of Environmental and Occupational Medicine, Steno Institute of Public Health, University of Aarhus, Aarhus, Denmark

Address all correspondence and reprint requests to: 0. Omland, M.D., Department of Environmental and Occupational Medicine, University of Aarhus, Universitetsparken, Building 180, DK-8000 Aarhus C, Denmark.

ABSTRACT: Exposure to PAH in foundry workers has been studied by urinary 1-hydroxypyrene (HPU) levels, quantitatively measured by reversed phase HPLC. Seventy male foundry workers and 68 matched controls were investigated. Polycyclic aromatic hydrocarbon (PAH) exposure was defined by 17 breathing zone hygienic samples, consisting of 16 selected PAH compounds. Mean total PAH concentration (SD) was 10.40 (4.04) micrograms/cubic meter. A multiple regression model of tobacco consumption, age, airborne PAH-exposure and foundry work on log HPU showed a significant correlation, p < 0.001, r squared = 0.69. Only foundry work (p < 0.0001) and airborne PAH exposure (p = 0.0478) contributed significantly to the model. These data suggest that HPU is a sensitive biomarker for low-dose PAH exposure.

KEY WORDS: foundry work, PAH exposure, 1-hydroxypyrene.