Cancer Detection and Prevention Volume 19 / Issue 5 (Sep-Oct 1995)

Table of Contents and Editor's Notes

The peer review process occasionally results in approval of controversial publications that do not necessarily reflect the viewpoint of the editors. Readers of the journal are encouraged to critically review and comment on presented data by submitting a "Letter to the Editor" that may be reprinted in a subsequent issue.

Association of Serum Antibodies Against Defined Epitopes of Human Papillomavirus L1, E2, and E7 Antigens and of HPV DNA with Incident Cervical Cancer

Lena Dillner, M.D., Agneta Zellbi, M.D. , Elisabeth Avall-Lundqvist, M.D., Pirkko Heino, M.Phil., Carina Eklund, B.Sc., Carl-Axel Pettersson, B.Sc. , 0lga Forslund, B.Sc. , Bengt-Goran Hansson, Ph.D. , Monica Grandien, M.D., Peter Bistoletti, M.D.,, and Joakim Dillner, M.D.

Human papillomavirus (HPV) DNA was detected by Southern blotting (SB) in 31 of 47 (66%) patients with cervical carcinoma and in 39 of 43 (91%) cases by the polymerase chain reaction (PCR). Tumors in stage lb were HPV positive in 52% by SB and in 84% by PCR, whereas tumors in stage Ila were HPV positive in 72% by SB and in 96% by PCR. >>>

Detection of Antibodies to Avian Leukosis/Sarcoma Viruses (ALSV) and Reticuloendotheliosis Viruses (REV) Humans by ELISA

Eric S. Johnson, M.B., B.S., Ph.D , Lori G. Nicholson, B.S., M.T. and David T. Durack, M.D., Ph.D.

Antibodies to avian leukosis/sarcoma were present in sera by the ELISA test in 19 of 45 (42.2%) poultry workers. Antireticuloendotheliosis virus antibody titers were positive in only 20% of the same group of 45 sera. The implication of human exposure to these viruses is discussed. >>>

Cytotoxic and Transforming Effects of Some Iron-Containing Minerals in Syrian Hamster Embryo Cells

Zoe Elias, M.D., Odile Poirot, M.S., Olga Schneider, Ph.D., Anne-Marie Marande, R.A., Marie-Ce1este Daniere, M.S. , Francine Terzetti, M.S., Henri Pezerat, Ph.D., Jeanine Foumier, Ph.D., and RogerZalma,Ph.D.

Cytotoxicity of iron-containing minerals and morphologic transformation of Syrian hamster embryo cells were studied to elucidate the increased risk of lung cancer among iron ore miners. Analysis of cell cycle kinetics revealed a time-and-date-dependent delay in progression of cells through the cycle with accumulation of cells in S and G2-N phases. >>>

The Effect of Dietary Omega-3 Polyunsaturated Fatty Acids on T-Lymphocyte Subsets of Patients with Solid Tumors

C. A. Gogos, M.D., P. Ginopoulos, M.D., N.C. Zoumbos, M.D., E. Apostolidou, M.D., and F. Kalfarentzos, M.D., F.A.C.N., F.A.C.S.

Twenty patients with solid tumors who received 18 g fish oil daily for 40 consecutive days had a significant increase in the T-helper/T-suppressor cell ratio mainly as a result of a decrease in the absolute number of T-suppressor cells. >>>

Chemoprevention of the Naturally Occurring Carcinogen 1-Hydroxyanthraquinone-Induced Carcinogenesis by the Nonsteroidal Anti-Inflammatory Drug Indomethacin in Rats

Takuji Tanaka, M.D., Masumi Suzui, M.D., Toshihiro Kojima, M.D., Kiyohisa Okamoto, M.D., Aijin Wang, M.D., and Hideki Mori, M.D.

Concurrent administration of indomethacin with 1-hydroxyanthraquinone (1-HA) to 69 male ACI/N rats inhibited 1-HA-induced carcinogenesis with a decrease in the bromodeoxyuridine labeling index of the colonic mucosa. >>>

IgD Myeloma: Clinical Characteristics and a New Staging System Based on Analysis of Japanese Patients

Yoshinori Shimamoto, M.D.

Clinical characteristics and prognostic factors of 165 Japanese IgD myeloma patients were compared with those of Western lgD myeloma patients. The five-year survival rate of Japanese patients was better than rates reported in Western countries. A strong predictive value for length of survival was found for Japanese patients. >>>

Changes in the Number of Silver-Stained Nucleolar Organizer Regions in the Normal, Preneoplastic, and Neoplastic Endometrium

Kenji Niwa, M.D., Ph.D., Toshiko Murase, M.D., Shigeo Morishita, M.D., Takuji Tanaka, M.D., Ph.D. , Kuniyasu Shimokawa, M.D., Ph.D., and Teruhiko Tamaya, M.D., Ph.D.

The mean number of silver-stained nucleolar organizer regions (AgNORs) in glandular endometrial cells of the normal menstrual cycle in the proliferative phase was significantly higher than it was in the secretory endometrium. In well-differentiated endometrial adenocarcinoma the number of AgNORs was significantly greater than it was in cases of hyperplasia. >>>

Metabolism of Dehydroepiandrosterone Sulphate by Breast Cysts: Possible Role in the Development of Breast Cancer

Leslie C. Lai, M.R.C.Path.

Needle aspirations of breast cyst fluids presented a significant percentage conversion of radiolabeled dehydroepiandrosterone sulphate (DHAS) to dehydroepiandrosterone (DHA). It is suggested that some of the enzymes responsible for sex steroid synthesis in breast cysts may be implicated in mammary carcinogenesis. >>>

Growth Fractions (KI-67) in Primary Breast Cancers, with Particular Reference to Node-Negative Tumors

Wolfgang Weikel, M.D., Carsten Brumm, M.D., Claudia Wilkens, Thomas Beck, M.D., and Paul-Georg Knapstein, M.D. Department of Gynecology and Obstetrics, Universitats-Frauenklinik Mainz, Mainz, Germany

In 234 node-negative cases of 549 primary breast carcinomas the use of monoclonal antibody Ki-67 discerned 3 groups of tumors, depending on the number of positive cells detected. Node-negative patients with tumors that contained a growth fraction of more than 20% positive cells had an adverse prognosis for both overall and disease-free survival. >>>

Cancer Metastasis: Negative Regulation by an Invasion-Suppressor Complex

Marc Mareel, M.D., Ph.D., Marc Bracke, M.D., Ph.D., and Frans Van Roy, M.D., Ph.D.

The E-cadherin/(alpha-, beta-, gamma-catenin complex) has an invasion suppressor function. Use of immunohistochemistry in more than 100 gastric cancers revealed a correlation of reduced E-cadherin expression, with local invasion and metastasis. In vitro studies with antisense sequences revealed that reduction in E-cadherin levels induced invasion while injection of E-cadherin-positive cells in syngeneic mice produced invasiveness and metastatic tumors. >>>


Herbert E. Nieburgs, MD
Worcester, MA