Published in Cancer Detection and Prevention 1995; 19(4):374-380.
T/Tn Antigen Vaccine is Effective and Safe in Preventing Recurrence of Advanced Breast CarcinomaaHeather M. Bligh Cancer Research Laboratories, Chicago Medical School, North Chicago, IL; bCancer Center, Northwestern Univ, Chicago, IL; and cDept of Statistics, Northwestern Univ, Evanston, IL
Address all correspondence and reprint requests to: Georg F Springer, M.D., Heather M. Bligh Cancer Research Laboratories, Chicago Medical School, 3333 Green Bay Rd., North Chicago, IL 60064.
ABSTRACT: Since 1974, and as of March, 1993, we have used T/Tn antigen vaccine in safe, specific, effective, long-term intradermal vaccination against recurrence of advanced breast carcinoma (CA). Staging is by the pathologic TNM system. Treatment is ad infinitum. Of 19 consecutive breast carcinoma patients vaccinated, six Stage IV, six Stage 111, and seven Stage II all survived >5 years postoperatively. Three Stage 111, three Stage IV, and five Stage 11 patients (i.e., II) survived > 10 to >18 years. Five others are alive but have not reached 10 years; three of them have no evidence of disease (NED). Three patients died of CA before reaching 10 years. An additional three breast CA patients are being treated for >2 years, but, <5 years postoperatively, they are NED. The vaccination area presented as a delayed-type hypersensitivity reaction with significant inflammation with increase of helper T lymphocytes and decrease of T suppressor/cytotoxic cell ratio.